6 Boc 1 oxa 6 azaspiro 3.3 heptan 3 onefrom Selleck Chemicals

BMS-1

BMS-1 is a small-molecule inhibitor of PD-1/PD-L1 interaction with IC50 of 6 nM.

Cat# S7911, SKU# S7911-25mg, 25mg, $497.00 Ask

TPCA-1

TPCA-1 (GW683965) is an inhibitor of IKK-2 with IC50 of 17.9 nM in a cell-free assay, inhibits...

Cat# S2824, SKU# S2824-10mg, 10mg, $170.00 Ask

FSL-1

FSL-1, a bacterial-derived toll-like receptor 2/6 (TLR2/6) agonist, enhances resistance to...

Cat# S8428, SKU# S8428-5mg, 5mg, $927.00 Ask

ITD-1

ITD-1 is a potent TGF-β inhibitor. It does not block the kinase activity of either type I...

Cat# S6713, SKU# S6713-10mM/1mL, 10mM/1mL, $117.00 Ask

HA14-1

HA14-1 is a non-peptidic ligand of a Bcl-2 surface pocket with IC50 of ~9 μM.

Cat# S1071, SKU# S1071-50mg, 50mg, $170.00 Ask

Liproxstatin-1

Liproxstatin-1 is a potent ferroptosis inhibitor with an IC50 of 22 nM.

Cat# S7699, SKU# S7699-100mg, 100mg, $997.00 Ask

Cited in: Acid Ceramidase Inhibitor LCL-805 Antagonizes Akt Signaling and Promotes Iron-Dependent Cell Death in Acute Myeloid Leukemia

Johnson Ung, et al., bioRxiv - Cancer Biology 2023

Quote: ... liproxstatin-1 (Selleck Chemicals, #S7699); ferrostatin-1 (Selleck Chemicals ...

TAPI-1

TAPI-1 is an ADAM17/TACE inhibitor, which blocks shedding of cytokine receptors. TAPI-1 is also...

Cat# S7434, SKU# S7434-1mg, 1mg, $270.00 Ask

Cited in: Targeting neuronal activity-regulated neuroligin-3 dependency for high-grade glioma therapy

Humsa S. Venkatesh, et al., bioRxiv - Neuroscience 2017

Quote: ... TAPI-1 at 20uM (ADAM17 inhibitor; S7434; Selleck Chemicals); GI 254023X at 200nM (ADAM10 inhibitor ...

Torin 1

Torin 1 is a potent inhibitor of mTORC1/2 with IC50 of 2 nM/10 nM in cell-free assays; exhibits...

Cat# S2827, SKU# S2827-10mg, 10mg, $170.00 Ask

Cited in: Adaptation of pancreatic cancer cells to nutrient deprivation is reversible and requires glutamine synthetase stabilization by mTORC1

Pei-Yun Tsai, et al., bioRxiv - Cancer Biology 2020

Quote: ... Torin 1 (Selleck Chemicals, S2827).

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WQ 1

WQ 1 is a high affinity and selective σ1 receptor antagonist with pKi values of 10.85, 6.53 and...

Cat# E0388, SKU# E0388-5mg, 5mg, $227.00 Ask

AMI-1

AMI-1 is a potent and specific Histone Methyltransferase (HMT) inhibitor with IC50 of 3.0 μM and...

Cat# S7884, SKU# S7884-10mM/1mL, 10mM/1mL, $117.00 Ask

RCM-1

RCM-1 is a nontoxic inhibitor of Forkhead box M1 (FOXM1) that suppresses goblet cell metaplasia...

Cat# S6898, SKU# S6898-25mg, 25mg, $717.00 Ask

BTB-1

BTB-1 is a novel, selective and reversible inhibitor of the mitotic motor protein Kif18A with...

Cat# S6796, SKU# S6796-5mg, 5mg, $97.00 Ask

Stafia-1

Stafia-1 is the first STAT5a inhibitor that inhibits STAT5a (IC50=22.2 μM, Ki=10.9 μM) with at...

Cat# E0485, SKU# E0485-25mg, 25mg, $870.00 Ask

NQDI-1

NQDI 1, an inhibitor of ASK1(apoptosis signal-regulating kinase 1), attenuates acute ischemic...

Cat# S8289, SKU# S8289-50mg, 50mg, $397.00 Ask

Spautin-1

Spautin-1 is a potent and specific autophagy inhibitor, and inhibits the deubiquitinating...

Cat# S7888, SKU# S7888-1g, 1g, $1470.00 Ask

LCS-1

LCS-1 is an inhibitor of superoxide dismutase 1(SOD1) with IC50 of 1.07 μM.

Cat# E2832, SKU# E2832-5mg, 5mg, $70.00 Ask

Necrostatin-1

Necrostatin-1 (Nec-1) is a specific RIP1 (RIPK1) inhibitor and inhibits TNF-α-induced...

Cat# S8037, SKU# S8037-10mg, 10mg, $97.00 Ask

Cited in: Acid Ceramidase Inhibitor LCL-805 Antagonizes Akt Signaling and Promotes Iron-Dependent Cell Death in Acute Myeloid Leukemia

Johnson Ung, et al., bioRxiv - Cancer Biology 2023

Quote: ... necrostatin-1 (Selleck Chemicals, #S8037); pepstatin A (Cayman ...

A2ti-1

A2ti-1 is a selective and high-affinity inhibitor of annexin A2/S100A10 heterotetramer (A2t)...

Cat# E1421, SKU# E1421-5mg, 5mg, $297.00 Ask

NGI-1

NGI-1 is an aminobenzamide-sulfonamide compound that targets both oligosaccharyltransferase...

Cat# S8750, SKU# S8750-10mM/1mL, 10mM/1mL, $99.00 Ask

Liproxstatin-1

Liproxstatin-1 is a potent ferroptosis inhibitor with an IC50 of 22 nM.

Cat# S7699, SKU# S7699-5mg, 5mg, $147.00 Ask

Cited in: Acid Ceramidase Inhibitor LCL-805 Antagonizes Akt Signaling and Promotes Iron-Dependent Cell Death in Acute Myeloid Leukemia

Johnson Ung, et al., bioRxiv - Cancer Biology 2023

Quote: ... liproxstatin-1 (Selleck Chemicals, #S7699); ferrostatin-1 (Selleck Chemicals ...

BMS-1

BMS-1 is a small-molecule inhibitor of PD-1/PD-L1 interaction with IC50 of 6 nM.

Cat# S7911, SKU# S7911-10mM/1mL, 10mM/1mL, $167.00 Ask

SC-1

SC-1 (1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea, STAT3-IN-7), a...

Cat# S0986, SKU# S0986-5mg, 5mg, $427.00 Ask

SANT-1

SANT-1 directly binds to Smoothened (Smo) receptor with Kd of 1.2 nM and inhibits Smo agonist...

Cat# S7092, SKU# S7092-10mM/1mL, 10mM/1mL, $157.00 Ask

AMI-1

AMI-1 is a potent and specific Histone Methyltransferase (HMT) inhibitor with IC50 of 3.0 μM and...

Cat# S7884, SKU# S7884-25mg, 25mg, $297.00 Ask

Necrostatin-1

Necrostatin-1 (Nec-1) is a specific RIP1 (RIPK1) inhibitor and inhibits TNF-α-induced...

Cat# S8037, SKU# S8037-100mg, 100mg, $270.00 Ask

Cited in: Acid Ceramidase Inhibitor LCL-805 Antagonizes Akt Signaling and Promotes Iron-Dependent Cell Death in Acute Myeloid Leukemia

Johnson Ung, et al., bioRxiv - Cancer Biology 2023

Quote: ... necrostatin-1 (Selleck Chemicals, #S8037); pepstatin A (Cayman ...

MID-1

MID-1 is a disruptor of MG53-IRS-1 (Mitsugumin 53-insulin receptor substrate-1) interaction,...

Cat# E0794, SKU# E0794-5mg, 5mg, $209.00 Ask

SANT-1

SANT-1 directly binds to Smoothened (Smo) receptor with Kd of 1.2 nM and inhibits Smo agonist...

Cat# S7092, SKU# S7092-50mg, 50mg, $570.00 Ask

ISO-1

ISO-1 (MIF Antagonist) is an inhibitor of MIF (Macrophage migration inhibitory factor)...

Cat# S7732, SKU# S7732-5mg, 5mg, $107.00 Ask

Stafia-1

Stafia-1 is the first STAT5a inhibitor that inhibits STAT5a (IC50=22.2 μM, Ki=10.9 μM) with at...

Cat# E0485, SKU# E0485-5mg, 5mg, $290.00 Ask

1-Naphthyl PP1(1-NA-PP1)

1-Naphthyl PP1(1-NA-PP 1) is a highly selective and potent pan-PKD inhibitor with IC50 of 154.6...

Cat# S2642, SKU# S2642-25mg, 25mg, $447.00 Ask

1-Naphthyl PP1(1-NA-PP1)

1-Naphthyl PP1(1-NA-PP 1) is a highly selective and potent pan-PKD inhibitor with IC50 of 154.6...

Cat# S2642, SKU# S2642-5mg, 5mg, $97.00 Ask

2-Methyl-3-Pentanone

2-Methyl-3-Pentanone is an aliphatic ketone with used as a reagent in organic chemistry and as a solvent.

Cat# S6161, SKU# S6161-25ul, 25ul, $97.00 Ask

Isorhamnetin 3-O-neohesperoside

Isorhamnetin 3-O-neohesperoside is the major active substance of Puhuang, a traditional herb...

Cat# S9455, SKU# S9455-5mg, 5mg, $397.00 Ask

Ethyl 3-Aminobenzoate methanesulfonate

Ethyl 3-Aminobenzoate (Ethyl m-Aminobenzoate, NSC 93790, Tricaine) can block the generation of...

Cat# S3682, SKU# S3682-25mg, 25mg, $97.00 Ask

3-(Trimethoxysilyl)propyl methacrylate

3-(Trimethoxysilyl)propyl methacrylate (TMPSM) is a reactive monomer and silane coupling agent....

Cat# E4021, SKU# E4021-1g, 1g, $397.00 Ask

Relatlimab (anti-LAG-3)

Relatlimab (BMS-986016, RELA) is a human LAG-3 specific monoclonal antibody that binds to LAG-3...

Cat# A2029, SKU# A2029-1mg*25, 1mg*25, $2127.00 Ask

LOX-IN-3 Dihydrochloride

LOX-IN-3 Dihydrochloride is an orally active and selective lysyl oxidase (LOX) inhibitor.

Cat# E0145, SKU# E0145-25mg, 25mg, $1497.00 Ask

3-(Trimethoxysilyl)propyl methacrylate

3-(Trimethoxysilyl)propyl methacrylate (TMPSM) is a reactive monomer and silane coupling agent....

Cat# E4021, SKU# E4021-100mg, 100mg, $79.00 Ask

Gefitinib-based PROTAC 3

Gefitinib-based PROTAC 3 which conjugates an EGFR binding element to a VHL ligand via a linker...

Cat# S0070, SKU# S0070-10mM/1mL, 10mM/1mL, $417.00 Ask

Kaempferol-3-O-glucorhamnoside

Kaempferol 3-neohesperidoside (Kaempferol 3-neohesperidoside), isolated from the herbs of...

Cat# S5468, SKU# S5468-1mg, 1mg, $147.00 Ask

(3-Carboxypropyl)trimethylammonium chloride

(3-Carboxypropyl)trimethylammonium chloride (γ;-Butyrobetaine, γ;BB hydrochloride) is an...

Cat# S3361, SKU# S3361-25mg, 25mg, $97.00 Ask

3-Chloro-L-tyrosine

3-Chloro-L-tyrosine, a specific marker of myeloperoxidase-catalyzed oxidation, is markedly...

Cat# S6106, SKU# S6106-25mg, 25mg, $97.00 Ask

Sabatolimab (anti-TIM-3)

Sabatolimab (anti-TIM-3) (MBG453, NVP-MBG453) is a high-affinity, humanized IgG4 antibody...

Cat# A2037, SKU# A2037-1mg*5, 1mg*5, $709.00 Ask

Gefitinib-based PROTAC 3

Gefitinib-based PROTAC 3 which conjugates an EGFR binding element to a VHL ligand via a linker...

Cat# S0070, SKU# S0070-5mg, 5mg, $370.00 Ask

Kaempferol-3-O-rutinoside

Kaempferol-3-O-rutinoside (Nicotiflorin, Nikotoflorin, Kaempferol 3-O-β-rutinoside), a flavonoid...

Cat# S3267, SKU# S3267-1mg, 1mg, $117.00 Ask

Kaempferol-3-O-neohesperidoside

Kaempferol 3-neohesperidoside (Kaempferol 3-O-neohesperidoside), a flavonoid isolated from the...

Cat# S3278, SKU# S3278-1mg, 1mg, $117.00 Ask

3-Indolebutyric acid (IBA)

3-Indolebutyric acid(IBA) is a plant hormone in the auxin family and is an ingredient in many...

Cat# S2253, SKU# S2253-10mg, 10mg, $120.00 Ask

Gefitinib-based PROTAC 3

Gefitinib-based PROTAC 3 which conjugates an EGFR binding element to a VHL ligand via a linker...

Cat# S0070, SKU# S0070-25mg, 25mg, $970.00 Ask

trans-3-Indoleacrylic acid

trans-3-Indoleacrylic acid is a metabolite of tryptophan.

Cat# S6105, SKU# S6105-25mg, 25mg, $107.00 Ask

cis-3-Hexenyl hexanoate

Cis-3-Hexenyl hexanoate ((Z)-3-hexenyl hexanoate) is a kind of plant volatile that brings...

Cat# S3317, SKU# S3317-100mg, 100mg, $97.00 Ask

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