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201 - 250 of 495 citations for 8 Chloro 2 chloromethyl imidazo 1 2 a pyridine since 2019

• Enhancing radiotherapy response via intratumoral injection of the TLR9 agonist CpG to stimulate CD8 T cells in an autochthonous mouse model of sarcoma

  Chang Su, et al., bioRxiv - Cancer Biology 2024

  Quote: ... Anti-PD-1 (BioXCell, BE0146) or isotype control (BioXCell ...
• Molecular and cellular phenotypic differences distinguish murine syngeneic models from human tumors

  Wenyan Zhong, et al., bioRxiv - Cancer Biology 2019

  Quote: Rat IgG2a to mouse PD-1/CD279 (clone RMP 1-14) was purchased from BioXcell and was dosed in vivo at 10 mpk i.v ...
• PD-1 and CTLA-4 exert additive control of effector regulatory T cells

  Joseph A. Perry, et al., bioRxiv - Immunology 2022

  Quote: ... or combination of PD-1 and CTLA-4 using anti-PD-1 (clone: RMP1-14, BioXcell), anti-CTLA-4 (clone ...
• Contrast-enhanced ultrasound measurement of pancreatic blood flow dynamics predicts type1 diabetes therapeutic reversal in preclinical models

  Vinh Pham, et al., bioRxiv - Bioengineering 2020

  Quote: ... clone 145-2C11 (BP0001-1; BioXCell). For verapamil treatment ...
• Integrin αvβ8 on T cells is responsible for suppression of anti-tumor immunity in multiple syngeneic models and is a promising target for tumor immunotherapy

  Eswari Dodagatta-Marri, et al., bioRxiv - Cancer Biology 2020

  Quote: ... anti-PD-1 (RMP1-14, BioXcell) or isotype control 2A3_rat IgG (BioXcell ...
• Multi-tier mechanics control stromal adaptations in swelling lymph nodes

  Frank P. Assen, et al., bioRxiv - Immunology 2021

  Quote: ... α-ICAM-1 (YN1/1.7.4) (BioXCell), α- VCAM-1 (Phe25-Glu698 ...
• Maximizing the Anti-tumor Potential of Immune Checkpoint Blockade through Modulation of Myeloid-specific CXCL16 and STAT1 Signaling

  Bhavana Palakurthi, et al., bioRxiv - Cancer Biology 2022

  Quote: ... both PD-1 inhibitor (BioXcell, BE0146) and IgG (BioXcell ...
• Human endogenous retrovirus activation contributes to biliary atresia pathogenesis through re-education of resident macrophages

  Jianpeng Sheng, et al., bioRxiv - Pathology 2022

  Quote: ... anti-mouse Ly6G (BE0075-1, BioXcell) at the dose of 10 mg/kg was applied to the 2-week BA mice 2 times a week.
• cDC1 Coordinate Innate and Adaptive Responses in the Omentum required for T cell Priming and Memory

  David A. Christian, et al., bioRxiv - Immunology 2020

  Quote: ... 1 µg/ml 2.4G2 (BioXCell: BE0307)] at 4°C for 10 min prior to staining ...
• THEMIS is a priming substrate of non-receptor tyrosine phosphatase PTPN6/SHP1 and plays dual roles during T cell development

  Jiali Zhang, et al., bioRxiv - Cell Biology 2021

  Quote: ... and anti-mCD28 (BioXcell, BE0015-1) antibodies coated on plate ...
• Oligodendrocyte-derived IL-33 functions as a microglial survival factor during neuroinvasive flavivirus infection

  Geoffrey T. Norris, et al., bioRxiv - Immunology 2023

  Quote: ... and 5 ug JES6-1 (BioXcell) intraperitoneally on days 2-4 post-infection in a total volume of 200 uL ...
• Senescent cells deposit intracellular contents through adhesion-dependent fragmentation

  Matej Durik, et al., bioRxiv - Cell Biology 2023

  Quote: ... anti-CD47 (1:1000, BioXcell, MIAP410), anti-ANXA2 (1:500 ...
• An mRNA-encoded, long-lasting Interleukin-2 restores CD8⁺ T cell neoantigen immunity in MHC class I-deficient cancers

  Jan D. Beck, et al., bioRxiv - Immunology 2023

  Quote: ... αPD-1 (clone RMP1-14, BioXCell) or αCTLA4 antibody (clone 9D9 ...
• Disrupting CD38-driven T cell dysfunction restores sensitivity to cancer immunotherapy

  Or-Yam Revach, et al., bioRxiv - Cancer Biology 2024

  Quote: ... anti-PD-1 (Bio X Cell, RMP1-14 ...
• One infusion of engineered long-lasting and multifunctional T cells cures asthma in mice

  Gang Jin, et al., bioRxiv - Immunology 2023

  Quote: ... Purified CD8+ T cells were activated by 1 μg/ml anti-CD3 (BioXCell, BP0001-1, RRID:AB 1107634) and 1 μg/ml anti-CD28 (Bio X Cell ...
• The efficacy of chemotherapy is limited by intratumoural senescent cells that persist through the upregulation of PD-L2

  Selim Chaib, et al., bioRxiv - Cancer Biology 2022

  Quote: ... anti-CD4 (clone GK1.5, BioXCell #BP0003-1), anti-CD8α (clone 2.43 ...
• Ivermectin converts cold tumors hot and synergies with immune checkpoint blockade for treatment of breast cancer

  Dobrin Draganov, et al., bioRxiv - Immunology 2020

  Quote: ... Anti-PD-1 (clone RMP1-14, BioXCell) was administered at 10 mg/kg by intraperitoneal injection in 50 µL sterile PBS ...
• Tumor-Intrinsic Response to IFNgamma Shapes the Tumor Microenvironment and Anti-PD-1 Response in NSCLC

  Bonnie L Bullock, et al., bioRxiv - Cancer Biology 2019

  Quote: ... or an anti-PD-1 antibody (BioXCell) at a dose of 200 Antibodies ...
• An engineered 4-1BBL fusion protein with “activity-on-demand”

  Jacqueline Mock, et al., bioRxiv - Cancer Biology 2020

  Quote: ... 200 αPD-1 (BioXCell, clone 29F.1A12) or a combination of the checkpoint inhibitor and the immunocytokine ...
• Blockade of LAG-3 in PD-L1-deficient mice enhances clearance of blood stage malaria independent of humoral responses

  Raquel Furtado, et al., bioRxiv - Immunology 2020

  Quote: ... or anti-PD-1 (RMP1-14, BioXcell) blocking Abs were injected i.v ...
• Interferon response and epigenetic modulation by SMARCA4 mutations drive ovarian tumor immunogenicity

  Melica Nourmoussavi Brodeur, et al., bioRxiv - Cancer Biology 2023

  Quote: ... or anti-mouse IFNAR-1 (BE0241, BioXCell) at 8-10 ug/mL ...
• T:B cell cooperation in ectopic lymphoid follicles propagates CNS autoimmunity

  Anna Kolz, et al., bioRxiv - Immunology 2023

  Quote: ... and anti-CD28 (clone PV-1; BioXCell) antibodies both at 2 µg/ml in fresh medium without any cytokines.
• Secreted antigen A peptidoglycan hydrolase is essential for Enterococcus faecium cell separation and priming of immune checkpoint inhibitor cancer therapy

  Steven Klupt, et al., bioRxiv - Microbiology 2023

  Quote: ... 100 ug anti–PD-1 (BioXCell, BP0146) were administered to the mice at Day 5 ...
• Brain tumor induce immunoregulatory dendritic cells in tumor draining lymph nodes that can be targeted by OX40

  Oscar Badillo-Godinez, et al., bioRxiv - Immunology 2024

  Quote: ... and αPDL-1 (10F.9G2TM) from BioXcell. In parallel experiments ...
• Integrated Analyses of Multi-omic Data Derived from Paired Primary Lung Cancer and Brain Metastasis Reveals the Metabolic Vulnerability as a Novel Therapeutic Target

  Hao Duan, et al., bioRxiv - Cancer Biology 2024

  Quote: ... anti-PD-1 antibody (BioXcell cat.# BE0146) at 100ug per mouse every 3 days ...
• CCR5 promotes the migration of CD8⁺ T cells to the leishmanial lesions

  Laís Amorim Sacramento, et al., bioRxiv - Immunology 2023

  Quote: ... clone GK1.5 (BioXCell, Cat #BE0003-1, RRID:AB_1107636) by intraperitoneal injections twice a week in the first two weeks post-infection[8].
• PSGL-1 directs early TCR signaling to repress metabolism and promote T cell exhaustion by modulating the TCF-1/TOX axis in CD8⁺ T cells

  Jennifer L. Hope, et al., bioRxiv - Immunology 2022

  Quote: Naïve WT (CD45.1+) or PSGL-1-/- (CD90.1+) OT-I CD8+ T cells were activated with immobilized anti-CD3ε (145-2C11, BioXcell) and anti-CD28 (37.51 ...
• Dihydroartemisinin broke immune evasion through YAP1/JAK1/STAT1, 3 pathways to enhance anti-PD-1 therapy in hepatocellular carcinoma

  Qing Peng, et al., bioRxiv - Cancer Biology 2021

  Quote: ... The mice of anti-PD-1 group were injected intraperitoneally with anti-PD-1 (BioXcell, USA, 10 mg/kg) every 3 d ...
• Regulatory T cells suppress the formation of potent KLRK1 and IL-7R expressing effector CD8 T cells by limiting IL-2

  Oksana Tsyklauri, et al., bioRxiv - Immunology 2022

  Quote: Anti-CD4 (GK1.5, #BE0003-1) and anti-CD8α (53-6.7, #BE0004-1) depletion antibodies were purchased from Bioxcell (USA).
• Induction of immortal-like and functional CAR-T cells by defined factors

  Lixia Wang, et al., bioRxiv - Immunology 2023

  Quote: ... and purified CD8+ T cells were activated by 1 μg/ml anti-CD3 (BioXCell, Cat# BP0001-1, RRID:AB 1107634) and 1 μg/ml anti-CD28 (BioXCell ...
• Serpine1 negatively regulates Th1 cell responses in experimental autoimmune encephalomyelitis

  Irshad Akbar, et al., bioRxiv - Immunology 2023

  Quote: ... into Th1 cells – 10 ng mL-1 rmIL-12 (R&D Biosystems) plus anti-IL-4 (10 μg mL-1, BioXcell), or Th17 – rhTGFβ (3 ng mL-1 ...
• Adoptive transfer of mitochondrial antigen-specific CD8⁺ T-cells in mice causes parkinsonism and compromises the dopamine system

  MN Elemeery, et al., bioRxiv - Neuroscience 2024

  Quote: ... 24-wells plates were coated with 1 µg/ml of anti-CD3 antibody (BioXcell, clone 14-2C11; Cat # BE0001-1) diluted in sterile PBS and then incubated at 5% CO2 at 37°C for 2h ...
• APOBEC mutagenesis inhibits breast cancer growth through induction of a T cell-mediated antitumor immune response

  Ashley V. DiMarco, et al., bioRxiv - Cancer Biology 2021

  Quote: ... 200 µg of anti-PD-1 (BioXCell BE0146) and 200 µg of anti-CTLA-4 (BioXCell BE0164) ...
• APOBEC mutagenesis inhibits breast cancer growth through induction of a T cell-mediated antitumor immune response

  Ashley V. DiMarco, et al., bioRxiv - Cancer Biology 2021

  Quote: ... 200 µg of anti-PD-1 (BioXCell BE0146), or 300 µg of anti-IgG2b (BioXCell BE0090) ...
• Contrast-enhanced ultrasound measurement of pancreatic blood flow dynamics predicts type1 diabetes therapeutic reversal in preclinical models

  Vinh Pham, et al., bioRxiv - Bioengineering 2020

  Quote: ... clone GK1.5 (BP0003-1; BioXCell, W. Lebanon, NH). For antiCD3 treatment ...
• Cancer Cell Intrinsic Expression of MHCII Regulates the Immune Microenvironment and Response to Anti-PD-1 Therapy in Lung Adenocarcinoma

  Amber M. Johnson, et al., bioRxiv - Cancer Biology 2020

  Quote: ... or an anti-PD-1 antibody (BioXCell #BE0146) twice weekly starting 7-10 days after injection of cancer cells.
• Pharmacologic activation of the G protein-coupled estrogen receptor inhibits pancreatic ductal adenocarcinoma

  Christopher A. Natale, et al., bioRxiv - Cancer Biology 2019

  Quote: ... and αPD-1 antibody (Clone: RMP1-14, BioXcell) were diluted in sterile PBS and delivered through intraperitoneal injections at a dose of 10mg/kg.
• Long-term T cell fitness and proliferation is driven by AMPK-dependent regulation of oxygen reactive species

  Anouk Lepez, et al., bioRxiv - Immunology 2020

  Quote: ... anti-CD28 (1 µg/ml, clone 37.51, BioXCell), recombinant IL-12 (10 ng/ml ...
• “A negative feedback loop mediated by the NR4A family of nuclear hormone receptors restrains expansion of B cells that receive signal one in the absence of signal two”

  Corey Tan, et al., bioRxiv - Immunology 2020

  Quote: ... anti-CD40L blocking Ab (clone MR-1, BioXcell).
• The efficacy of chemotherapy is limited by intratumoural senescent cells that persist through the upregulation of PD-L2

  Selim Chaib, et al., bioRxiv - Cancer Biology 2022

  Quote: ... anti-CD8α (clone 53-6.7, BioXCell #BE0004-1), or rat IgG (IgG2a isotype ...
• The Siglec-sialic acid-axis is a target for innate immunotherapy of glioblastoma

  Philip Schmassmann, et al., bioRxiv - Cancer Biology 2022

  Quote: Anti-mouse PD-1 (clone RMP1-14, BioXcell) and isotype control (rat IgG2a ...
• Agonistic anti-CD40 converts Tregs into Type 1 effectors within the tumor micro-environment

  Vivien Maltez, et al., bioRxiv - Immunology 2022

  Quote: ... αPD-1 (RMP1-14; BioXcell; 200 μg/dose) was injected intraperitoneally (i.p. ...
• Commensal-specific CD4 T cells promote inflammation in the central nervous system via molecular mimicry

  Zachary White, et al., bioRxiv - Immunology 2022

  Quote: ... and anti-PD-1 (BioXCell BE0146: Clone:RMP1-14) were injected into these animals (i.p.) ...
• Novel populations of Tr1 cells contribute to the resolution of acute influenza A virus infection

  Caitlin A Abbott, et al., bioRxiv - Immunology 2022

  Quote: ... Soluble αCD3 (145-2C11, BioXcell, 1 µg / mL) was added on top ...
• Pseudorabies virus hijacks DDX3X, initiating an addictive “mad itch” and immune suppression, to facilitate viral spread

  Shane J. F. Cronin, et al., bioRxiv - Neuroscience 2023

  Quote: ... anti-mouse Ly-6G antibody (BioxCell, BE0075-1), anti-mouse IL-6 antibody (BioXCell ...
• The circadian clock is a pacemaker of the axonal regenerative ability

  Francesco De Virgiliis, et al., bioRxiv - Neuroscience 2023

  Quote: ... anti-Ly6G (1:500, mouse, BioxCell, clone 1A8), anti-Bmal1 (1:500 ...
• Functional synapses between small cell lung cancer and glutamatergic neurons

  Anna Schmitt, et al., bioRxiv - Cancer Biology 2023

  Quote: ... The anti–PD-1 antibody RMP1-14 (BioXCell) was administered i.p ...
• Lactose blocks intercellular spreading of Galectin-1 from cancer cells to T-cells and activates tumor immunological control

  Yu Hong, et al., bioRxiv - Immunology 2023

  Quote: ... anti-PD-1 (Clone RMP1-14, BioXCell, BE0146) or anti-PD-L1 (Clone 10F.9G2 ...
• CRISPR/Cas9 screen identifies KRAS-induced COX-2 as a driver of immunotherapy resistance in lung cancer

  Jesse Boumelha, et al., bioRxiv - Cancer Biology 2023

  Quote: ... 200μg anti-PD-1 (clone RMP1-14, BioXcell) or the respective IgG control ...
• One signal activated TIL enable potent anti-tumor activity across diverse solid tumor types

  Yongqiang Wu, et al., bioRxiv - Immunology 2024

  Quote: ... Anti-PD-1 antibody (clone RMP1-14, BioXcell) was injected intraperitoneally in the corresponding groups at day 6 and day 18 after tumor cell inoculation ...