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1 - 50 of 351 citations for 7 BROMOMETHYL 1 CHLOROISOQUINOLINE since 2019

• IRF4 deficiency vulnerates B cell progeny for leukemogenesis via somatically acquired Jak3 mutations conferring IL-7 hypersensitivity

  Dennis Das Gupta, et al., bioRxiv - Cancer Biology 2022

  Quote: ... anti-IL-7 (BioXCell, 10 µg/ml), rmIL-7 or respective combinations ...
• T cell-mediated development of stromal fibroblasts with an immune-enhancing chemokine profile

  Ran Yan, Douglas T. Fearon, bioRxiv - Immunology 2022

  Quote: ... and anti-CD8 (clone 53.6-7, BioXcell) antibodies intraperitoneally twice per week ...
• Lymph node-targeted vaccine boosting of TCR-T cell therapy enhances anti-tumor function and eradicates solid tumors

  Dylan J. Drakes, et al., bioRxiv - Immunology 2022

  Quote: ... mice were rechallenged with 5×105 B16F10 GFP-LUC cells on day 75 post T cell transfer with or without intraperitoneal injection of 250 μg anti-Thy1.1 antibody (Days −7, 0, 7, 14, 21, 28, 35) (BioXCell) to deplete adoptively transferred pmel-1 T cells that are Thy1.1 expressing ...
• IRF4 deficiency vulnerates B cell progeny for leukemogenesis via somatically acquired Jak3 mutations conferring IL-7 hypersensitivity

  Dennis Das Gupta, et al., bioRxiv - Cancer Biology 2022

  Quote: ... transduced cells were split and cultured with either recombinant murine (rm)IL-7 or 10 µg/ml neutralizing anti-IL-7 antibody (BE0048, Bio X Cell). Same protocol applied for STAT5ca-RV transduction ...
• Distinct cell adhesion signature defines glioblastoma myeloid-derived suppressor cell subsets

  Defne Bayik, et al., bioRxiv - Immunology 2021

  Quote: ... InVivoMAb anti-mouse/human integrin β7 (clone FIB504, BE0062) and InVivoMAb rat IgG2a isotype control, anti-trinitrophenol (clone 2A3, BE0089) antibodies were purchased from BioXCell.
• Sympathetic Signals Promote Immunosuppressive Neutrophils in Lung Tumors

  Jiaqi Liu, et al., bioRxiv - Neuroscience 2024

  Quote: ... MMTV-PyMT +/- female mice at 7 weeks after the tumor onset were intravenously injected with the anti-PD-L1 antibody (BioXcell, #BE0101 ...
• Upregulated PD-1 Signaling is an Important Antagonist to Glomerular Health in Aged Kidneys

  Jeffrey W. Pippin, et al., bioRxiv - Cell Biology 2021

  Quote: ... (2) aged-matched control mice (n=7) that received weekly IP injections of the isotype control IgG2A antibody (2A3, Bio X Cell, Lebanon, NH) at 12 mg/kg for 8 weeks ...
• Interplay of the Trypanosome Lytic Factor and innate immune cells in the resolution of cutaneous Leishmania infection

  Jyoti Pant, et al., bioRxiv - Microbiology 2020

  Quote: ... (BioXcell, BP0075-1, 1 mg). Isotype matched IgG2a ...
• Activation of the aryl hydrocarbon receptor inhibits neuropilin-1 upregulation on IL-2 responding CD4⁺ T cells

  Simone Sandoval, et al., bioRxiv - Immunology 2023

  Quote: ... The anti-IL2 contained a 1:1 mixture of S4B6 (BioXcell; Cat # BE0043-1) and JES6-1a12 (BioXcell ...
• Selective Inhibition of Interleukin-2 Inducible T Cell Kinase (ITK) Enhances Anti-Tumor Immunity in Association with Th1-skewing, Cytotoxic T cell Activation, and Reduced T Cell Exhaustion

  Lih-Yun Hsu, et al., bioRxiv - Cancer Biology 2023

  Quote: ... or anti-PD-1 (RPM 1-14, BioXcell) and/or anti-CTLA4 (9H10 ...
• CXCR4 controls movement and degranulation of CD8⁺ T cells in the influenza-infected lung via differential effects on interaction and tissue scanning

  Paulus Mrass, et al., bioRxiv - Immunology 2022

  Quote: ... and CD28 (1 μg/ml; clone PV-1; BioXCell). We cultured the T cells in DMEM medium (Gibco ...
• Universal recording of cell-cell contacts in vivo for interaction-based transcriptomics

  Sandra Nakandakari-Higa, et al., bioRxiv - Immunology 2023

  Quote: ... incubated with 1 μg ml−1 anti-CD16/32 (2.4G2, BioXCell) for 5 min at room temperature and then stained for cell surface markers at 4 °C for 20 min in PBS using the reagents listed in Supplementary Table 1 ...
• Beneficial Effects of Celastrol on Immune Balance by Modulating Gut Microbiota in Dextran Sodium Sulfate-Induced Ulcerative Colitis

  Mingyue Li, et al., bioRxiv - Microbiology 2021

  Quote: ... 10 μg·ml-1 anti-IL-4 and 10 μg·ml-1 anti-IL-2 (Bio X Cell, Cat# BE0043-1, RRID:AB_1107705). For Treg cell differentiation ...
• Serpine1 negatively regulates Th1 cell responses in experimental autoimmune encephalomyelitis

  Irshad Akbar, et al., bioRxiv - Immunology 2023

  Quote: ... or Th17 – rhTGFβ (3 ng mL-1, Miltenyi) + rmIL-6 (20 ng mL-1, Miltenyi) + anti-IFNγ (10 μg mL-1, BioXcell). Cells were then transferred to uncoated tissue culture plates and cultured for an additional 3 days ...
• Development of A Novel Highly Selective TLR8 Agonist for Cancer Immunotherapy

  Yuxun Wang, et al., bioRxiv - Pharmacology and Toxicology 2020

  Quote: ... The anti-PD-1 monoclonal antibody αPD-1 (Clone RMP1-14, Bioxcell) was administered at 10 mg/kg ...
• One infusion of engineered long-lasting and multifunctional T cells cures asthma in mice

  Gang Jin, et al., bioRxiv - Immunology 2023

  Quote: ... and 1 μg/ml anti-CD28 (Bio X Cell, BE0015-1, RRID:AB_1107624) overnight.
• Induction of immortal-like and functional CAR-T cells by defined factors

  Lixia Wang, et al., bioRxiv - Immunology 2023

  Quote: ... and 1 μg/ml anti-CD28 (BioXCell, Cat# BP0015-1, RRID:AB 1107624) overnight.
• Bi-steric mTORC1-selective Inhibitors activate 4EBP1 reversing MYC-induced tumorigenesis and synergize with immunotherapy

  Wadie D. Mahauad-Fernandez, et al., bioRxiv - Cancer Biology 2022

  Quote: ... α-PD-1 (BioXCell Clone RMP1-14 and catalog number BE0146) ...
• Combined MEK and STAT3 inhibition reprograms stromal inflammation to overcome immunotherapy resistance in pancreatic cancer

  Jashodeep Datta, et al., bioRxiv - Cancer Biology 2022

  Quote: ... αPD-1 antibody (BioXCell, Clone #BE0273 ...
• Distinct functions of EHMT1 and EHMT2 in cancer chemotherapy and immunotherapy

  Zhihua Kang, et al., bioRxiv - Cancer Biology 2023

  Quote: ... and Vehicle+anti-PD-1 and UNC0642+anti-PD-1 mice were treated with 200 μg anti-PD-1 (BioXCell, BE0273) via intraperitoneal (i.p. ...
• Human neural stem cells restore spatial memory in a transgenic Alzheimer’s disease mouse model by an immunomodulating mechanism

  Kevin S. Chen, et al., bioRxiv - Neuroscience 2023

  Quote: ... and CD40L (clone MR-1, Armenian hamster IgG; catalog # BE0017-1, Bio X Cell). Injections (20 mg/kg intraperitoneal for each antibody ...
• PSGL-1 directs early TCR signaling to repress metabolism and promote T cell exhaustion by modulating the TCF-1/TOX axis in CD8⁺ T cells

  Jennifer L. Hope, et al., bioRxiv - Immunology 2022

  Quote: ... anti-PSGL-1 (4RA10, BioXcell), or both for 15 minutes at 4°C ...
• Overcoming resistance to immune checkpoint therapy in PTEN-null prostate cancer by sequential intermittent anti-PI3Kα/β/δ and anti-PD-1 treatment

  Zhi Qi, et al., bioRxiv - Cancer Biology 2020

  Quote: ... Anti-PD-1 (BioXcell, BE0146) or isotype control (BioXcell ...
• Mismatch repair deficiency is not sufficient to increase tumor immunogenicity

  Peter M K Westcott, et al., bioRxiv - Cancer Biology 2021

  Quote: ... αPD-1 (29F.1A12, BioXCell) was administered at 200 μg three times a week ...
• Activating a collaborative innate-adaptive immune response to control breast and ovarian cancer metastasis

  Lijuan Sun, et al., bioRxiv - Cancer Biology 2020

  Quote: Anti-CD8 (#BE0004-1, BioXCell) and anti-CD4 (#BE0003-1 ...
• A single cell atlas reveals distinct immune landscapes in transplant and primary tumors that determine response or resistance to immunotherapy

  Amy J. Wisdom, et al., bioRxiv - Cancer Biology 2020

  Quote: ... Anti-CD4 (BioXCell, BE0003-1) and anti-CD8 (BioXCell ...
• Enhancing radiotherapy response via intratumoral injection of the TLR9 agonist CpG to stimulate CD8 T cells in an autochthonous mouse model of sarcoma

  Chang Su, et al., bioRxiv - Cancer Biology 2024

  Quote: ... Anti-PD-1 (BioXCell, BE0146) or isotype control (BioXCell ...
• Organoid Polymer Functionality and Mode of Klebsiella Pneumoniae Membrane Antigen Presentation Regulates Ex Vivo Germinal Center Epigenetics in Young and Aged B Cells

  Pamela L. Graney, et al., bioRxiv - Immunology 2020

  Quote: ... organoid media was replenished on days 1 or 2 with 50 μg/mL mouse anti-CD40L (Clone MR-1, Bio X Cell #BE0017-1), 50 μM BCL6 inhibitor 79-6 (Sigma #197345) ...
• Molecular and cellular phenotypic differences distinguish murine syngeneic models from human tumors

  Wenyan Zhong, et al., bioRxiv - Cancer Biology 2019

  Quote: Rat IgG2a to mouse PD-1/CD279 (clone RMP 1-14) was purchased from BioXcell and was dosed in vivo at 10 mpk i.v ...
• PD-1 and CTLA-4 exert additive control of effector regulatory T cells

  Joseph A. Perry, et al., bioRxiv - Immunology 2022

  Quote: ... or combination of PD-1 and CTLA-4 using anti-PD-1 (clone: RMP1-14, BioXcell), anti-CTLA-4 (clone ...
• Contrast-enhanced ultrasound measurement of pancreatic blood flow dynamics predicts type1 diabetes therapeutic reversal in preclinical models

  Vinh Pham, et al., bioRxiv - Bioengineering 2020

  Quote: ... clone 145-2C11 (BP0001-1; BioXCell). For verapamil treatment ...
• Integrin αvβ8 on T cells is responsible for suppression of anti-tumor immunity in multiple syngeneic models and is a promising target for tumor immunotherapy

  Eswari Dodagatta-Marri, et al., bioRxiv - Cancer Biology 2020

  Quote: ... anti-PD-1 (RMP1-14, BioXcell) or isotype control 2A3_rat IgG (BioXcell ...
• Multi-tier mechanics control stromal adaptations in swelling lymph nodes

  Frank P. Assen, et al., bioRxiv - Immunology 2021

  Quote: ... α-ICAM-1 (YN1/1.7.4) (BioXCell), α- VCAM-1 (Phe25-Glu698 ...
• Maximizing the Anti-tumor Potential of Immune Checkpoint Blockade through Modulation of Myeloid-specific CXCL16 and STAT1 Signaling

  Bhavana Palakurthi, et al., bioRxiv - Cancer Biology 2022

  Quote: ... both PD-1 inhibitor (BioXcell, BE0146) and IgG (BioXcell ...
• Human endogenous retrovirus activation contributes to biliary atresia pathogenesis through re-education of resident macrophages

  Jianpeng Sheng, et al., bioRxiv - Pathology 2022

  Quote: ... anti-mouse Ly6G (BE0075-1, BioXcell) at the dose of 10 mg/kg was applied to the 2-week BA mice 2 times a week.
• cDC1 Coordinate Innate and Adaptive Responses in the Omentum required for T cell Priming and Memory

  David A. Christian, et al., bioRxiv - Immunology 2020

  Quote: ... 1 µg/ml 2.4G2 (BioXCell: BE0307)] at 4°C for 10 min prior to staining ...
• THEMIS is a priming substrate of non-receptor tyrosine phosphatase PTPN6/SHP1 and plays dual roles during T cell development

  Jiali Zhang, et al., bioRxiv - Cell Biology 2021

  Quote: ... and anti-mCD28 (BioXcell, BE0015-1) antibodies coated on plate ...
• Oligodendrocyte-derived IL-33 functions as a microglial survival factor during neuroinvasive flavivirus infection

  Geoffrey T. Norris, et al., bioRxiv - Immunology 2023

  Quote: ... and 5 ug JES6-1 (BioXcell) intraperitoneally on days 2-4 post-infection in a total volume of 200 uL ...
• Senescent cells deposit intracellular contents through adhesion-dependent fragmentation

  Matej Durik, et al., bioRxiv - Cell Biology 2023

  Quote: ... anti-CD47 (1:1000, BioXcell, MIAP410), anti-ANXA2 (1:500 ...
• An mRNA-encoded, long-lasting Interleukin-2 restores CD8⁺ T cell neoantigen immunity in MHC class I-deficient cancers

  Jan D. Beck, et al., bioRxiv - Immunology 2023

  Quote: ... αPD-1 (clone RMP1-14, BioXCell) or αCTLA4 antibody (clone 9D9 ...
• Disrupting CD38-driven T cell dysfunction restores sensitivity to cancer immunotherapy

  Or-Yam Revach, et al., bioRxiv - Cancer Biology 2024

  Quote: ... anti-PD-1 (Bio X Cell, RMP1-14 ...
• One infusion of engineered long-lasting and multifunctional T cells cures asthma in mice

  Gang Jin, et al., bioRxiv - Immunology 2023

  Quote: ... Purified CD8+ T cells were activated by 1 μg/ml anti-CD3 (BioXCell, BP0001-1, RRID:AB 1107634) and 1 μg/ml anti-CD28 (Bio X Cell ...
• The efficacy of chemotherapy is limited by intratumoural senescent cells that persist through the upregulation of PD-L2

  Selim Chaib, et al., bioRxiv - Cancer Biology 2022

  Quote: ... anti-CD4 (clone GK1.5, BioXCell #BP0003-1), anti-CD8α (clone 2.43 ...
• Ivermectin converts cold tumors hot and synergies with immune checkpoint blockade for treatment of breast cancer

  Dobrin Draganov, et al., bioRxiv - Immunology 2020

  Quote: ... Anti-PD-1 (clone RMP1-14, BioXCell) was administered at 10 mg/kg by intraperitoneal injection in 50 µL sterile PBS ...
• Tumor-Intrinsic Response to IFNgamma Shapes the Tumor Microenvironment and Anti-PD-1 Response in NSCLC

  Bonnie L Bullock, et al., bioRxiv - Cancer Biology 2019

  Quote: ... or an anti-PD-1 antibody (BioXCell) at a dose of 200 Antibodies ...
• An engineered 4-1BBL fusion protein with “activity-on-demand”

  Jacqueline Mock, et al., bioRxiv - Cancer Biology 2020

  Quote: ... 200 αPD-1 (BioXCell, clone 29F.1A12) or a combination of the checkpoint inhibitor and the immunocytokine ...
• Blockade of LAG-3 in PD-L1-deficient mice enhances clearance of blood stage malaria independent of humoral responses

  Raquel Furtado, et al., bioRxiv - Immunology 2020

  Quote: ... or anti-PD-1 (RMP1-14, BioXcell) blocking Abs were injected i.v ...
• T:B cell cooperation in ectopic lymphoid follicles propagates CNS autoimmunity

  Anna Kolz, et al., bioRxiv - Immunology 2023

  Quote: ... and anti-CD28 (clone PV-1; BioXCell) antibodies both at 2 µg/ml in fresh medium without any cytokines.
• Interferon response and epigenetic modulation by SMARCA4 mutations drive ovarian tumor immunogenicity

  Melica Nourmoussavi Brodeur, et al., bioRxiv - Cancer Biology 2023

  Quote: ... or anti-mouse IFNAR-1 (BE0241, BioXCell) at 8-10 ug/mL ...
• CCR5 promotes the migration of CD8⁺ T cells to the leishmanial lesions

  Laís Amorim Sacramento, et al., bioRxiv - Immunology 2023

  Quote: ... clone GK1.5 (BioXCell, Cat #BE0003-1, RRID:AB_1107636) by intraperitoneal injections twice a week in the first two weeks post-infection[8].