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1 - 50 of 128 citations for 4 4 Bromophenylsulfonyl morpholine since 2020

• IL-31 uncouples skin inflammation from itch sensation in allergic dermatitis

  Marlys S. Fassett, et al., bioRxiv - Immunology 2021

  Quote: ... and anti-IL-4 (BioXCell); for Th2 ...
• Pre-existing intratumoral CD8 T cells substantially contribute to control tumors following therapeutic anti-CD40 and polyI:C based vaccination

  Aaron D. Stevens, Timothy N.J. Bullock, bioRxiv - Immunology 2020

  Quote: ... LFA blocking antibody (M17/4; BioXCell) was administered i.p ...
• A single cell atlas reveals distinct immune landscapes in transplant and primary tumors that determine response or resistance to immunotherapy

  Amy J. Wisdom, et al., bioRxiv - Cancer Biology 2020

  Quote: ... and anti-CTLA-4 (BioXCell, BE0164) or isotype control (MSD IgG1 control for muDX400 ...
• Targeting EIF4A triggers an interferon response to synergize with chemotherapy and suppress triple-negative breast cancer

  Na Zhao, et al., bioRxiv - Cancer Biology 2023

  Quote: ... and anti-CTLA-4 (BioXCell # BE0164) were diluted in PBS and dosed at 10 mg/kg every 3 days ...
• The metabolic cofactor Coenzyme A enhances alternative macrophage activation via MyD88-linked signaling

  Anthony E. Jones, et al., bioRxiv - Immunology 2024

  Quote: ... and IL-4-reactive monoclonal antibodies for in vivo studies (IL-4 MAb) were purchased from BioXCell (BE0045). All TLR agonists were purchased from Invivogen ...
• SLIT2-ROBO signaling in tumor-associated microglia/macrophages drives glioblastoma immunosuppression and vascular dysmorphia

  Luiz Henrique Geraldo, et al., bioRxiv - Cancer Biology 2021

  Quote: ... and anti-4-1BB (clone LOB12.3, BioXCell) treatment ...
• The guanine nucleotide exchange factor Rin-like acts as a gatekeeper for T follicular helper cell differentiation via regulating CD28 signaling

  Lisa Sandner, et al., bioRxiv - Immunology 2022

  Quote: ... and 3μg/mL anti–IL-4 (BioXcell) were used ...
• INHBA/Activin A promotes tumor growth and induces resistance to anti-PD-L1 therapy by suppressing IFN-γ signaling

  Fanglin Li, et al., bioRxiv - Immunology 2023

  Quote: Studies of anti-CTLA-4 (BE0032, BioXcell) therapy in mice bearing CT26 and B16 tumors ...
• Steady-state, therapeutic, and helminth-induced IL-4 compromise protective CD8 T cell bystander activation

  Nicholas J Maurice, et al., bioRxiv - Immunology 2024

  Quote: ... with anti-IL-4 (clone: 11B11; BioXCell) at a 1:5 ratio by mass ...
• PD-1 and CTLA-4 exert additive control of effector regulatory T cells

  Joseph A. Perry, et al., bioRxiv - Immunology 2022

  Quote: ... Inhibition of CTLA-4 signaling was performed by intraperitoneal injection of 500μg/dose of αCTLA-4 (clone: UC10-4F10-11, BioXcell) supplemented with 1mg/dose of IgG2b isotype (clone ...
• Long-term T cell fitness and proliferation is driven by AMPK-dependent regulation of oxygen reactive species

  Anouk Lepez, et al., bioRxiv - Immunology 2020

  Quote: ... and anti-IL-4 (10 µg/ml, BioXCell). Th1 cells were then cultured ...
• T:B cell cooperation in ectopic lymphoid follicles propagates CNS autoimmunity

  Anna Kolz, et al., bioRxiv - Immunology 2023

  Quote: ... and anti-IL-4 antibody (clone 11B11, BioXCell) at a concentration of 10 µg/ml ...
• PD-1 and CTLA-4 exert additive control of effector regulatory T cells

  Joseph A. Perry, et al., bioRxiv - Immunology 2022

  Quote: ... anti-CTLA-4 (clone: UC10-4F10-11, BioXcell) or isotype control antibodies (clone ...
• Memory Th1 cells modulate heterologous diseases through innate function

  NIkolas Rakebrandt, et al., bioRxiv - Immunology 2023

  Quote: ... and anti-IL-4 Ab (clone 11B11, BioXCell) at a concentration of 10 µg/ml ...
• A Nanoparticle RIG-I Agonist for Cancer Immunotherapy

  Lihong Wang-Bishop, et al., bioRxiv - Bioengineering 2023

  Quote: ... Mice in groups receiving αPD-1 and αCTLA-4 (100 µg, every 3 days for 4 injections, BioXcell, West Lebanon NH) were treated intraperitoneally ...
• APOBEC mutagenesis inhibits breast cancer growth through induction of a T cell-mediated antitumor immune response

  Ashley V. DiMarco, et al., bioRxiv - Cancer Biology 2021

  Quote: ... and 200 µg of anti-CTLA-4 (BioXCell BE0164), or 400 µg of anti-IgG2b isotype control (BioXCell BE0090) ...
• An immunogenic model of KRAS-mutant lung cancer for study of targeted therapy and immunotherapy combinations

  Jesse Boumelha, et al., bioRxiv - Cancer Biology 2022

  Quote: ... and 200 μg anti-CTLA-4 (clone 9H10, BioXcell), or their respective IgG controls ...
• The Goldilocks Principle conferred by LDH isoenzymes controls murine T cell glycolysis and differentiation

  Xuyong Chen, Lingling Liu, Ruoning Wang, bioRxiv - Immunology 2022

  Quote: ... anti–mIL-4 (8 μg/mL, Bio X Cell), and anti–mIFN-γ (8 μg/mL ...
• Dual blockade of IL-6 and CTLA-4 regresses pancreatic tumors in a CD4⁺ T cell-dependent manner

  Michael Brandon Ware, et al., bioRxiv - Cancer Biology 2020

  Quote: ... anti-IL-6 or anti-CTLA-4 antibodies (BioXCell). For CXCR3 blockade studies ...
• Succinate dehydrogenase/complex II is critical for metabolic and epigenetic regulation of T cell proliferation and inflammation

  Xuyong Chen, et al., bioRxiv - Immunology 2021

  Quote: ... anti–mIL-4 (8 μg/mL, Bio X Cell), and anti–mIFN-γ (8 μg/mL ...
• IL-4-induced hysteresis in naïve T cell activation

  Alexandre P. Meli, et al., bioRxiv - Immunology 2020

  Quote: ... and anti-IL-4 (clone 11B11, Bio X Cell). Briefly ...
• IL-7 mediated upregulation of VLA-4 increases accumulation of adoptively transferred T lymphocytes in murine glioma

  Kirit Singh, et al., bioRxiv - Cancer Biology 2024

  Quote: ... anti-4-1BB (clone LOB12.3, Bio X Cell #BP0169), anti-PD-1 (clone 29F.1A12 ...
• Agonistic anti-CD40 converts Tregs into Type 1 effectors within the tumor micro-environment

  Vivien Maltez, et al., bioRxiv - Immunology 2022

  Quote: ... 15 and αCTLA-4 (9H10; BioXcell; 200 μg/dose) on days 0 ...
• Mitochondrial Fatty Acid Synthesis and Mecr Regulate CD4⁺ T Cell Function and Oxidative Metabolism

  KayLee K. Steiner, et al., bioRxiv - Immunology 2024

  Quote: ... 10µg/mL anti-IL-4 (Bio X Cell, BP0045), Th2 (10ng/mL recombinant human IL-2 ...
• Haem toxicity in the aged spleen impairs T-cell immunity through iron deprivation

  David Ezuz, et al., bioRxiv - Immunology 2024

  Quote: ... and anti-CD28 (4 μg/mL; BioXcell BE0015-1). Resting cells were supplemented with 5 ng/ml recombinant murine IL-7 (Peprotech 217-17-10) ...
• The PD-1 checkpoint receptor maintains tolerance of self-reactive CD8 T cell in skin

  Martina Damo, et al., bioRxiv - Immunology 2021

  Quote: ... and CTLA-4 blocking antibody (clone 9D9, BioXCell, cat. BE0164) were administered either in combination or as single agents at 100ug/antibody/mouse every third day starting on the day of doxycycline diet addition for four total doses.
• Th2 Cytokine Modulates Herpesvirus Reactivation in a Cell Type Specific Manner

  Guoxun Wang, et al., bioRxiv - Microbiology 2020

  Quote: ... and 25 μg of anti-IL-4 (BioXcell, clone 11B11) were complexed prior to intraperitoneally injection into mice ...
• Loss of ACKR4 in tumor cells dysregulates dendritic cell migration to tumor-draining lymph nodes and T-cell priming

  Dechen Wangmo, et al., bioRxiv - Cancer Biology 2021

  Quote: ... anti-4-1BB agonist (5 mg/kg, clone: 3H3, BioXcell), or anti-PD-1 (10 mg/kg ...
• T cells modulate the microglial response to brain ischemia

  Corinne Benakis, et al., bioRxiv - Immunology 2021

  Quote: ... TREG conditions: anti–IL-4 (10 μg/mL, BioXCell, #BE0045), anti-IFN-γ (10 μg/mL ...
• The dietary fiber guar gum ameliorates experimental autoimmune encephalomyelitis via attenuated Th1 activation and differentiation

  Naomi M Fettig, et al., bioRxiv - Immunology 2022

  Quote: ... and 10 μg/mL a-IL-4 (clone 11B11, BioXCell). For Th17 conditions ...
• IL-7 mediated upregulation of VLA-4 increases accumulation of adoptively transferred T lymphocytes in murine glioma

  Kirit Singh, et al., bioRxiv - Cancer Biology 2024

  Quote: ... and anti-CTLA-4 (clone 9D9, Bio X Cell, #BE0164) were performed as part of this study ...
• CD39⁺ conventional CD4⁺ T cells with exhaustion traits and cytotoxic potential infiltrate tumors and expand upon CTLA-4 blockade

  Sabrina N. Bossio, et al., bioRxiv - Immunology 2023

  Quote: ... Tumor-bearing mice were treated with anti-CTLA-4 (BioXCell) (n=8 ...
• Arkadia-SKI/SnoN signaling cascade differentially regulates TGF-β-induced iTreg and Th17 cell differentiation

  Hao Xu, et al., bioRxiv - Immunology 2021

  Quote: ... plus 2 µg/mL anti-IL-4 antibody (BioXcell, Clone: 11B11); Th17 ...
• Prolonged T cell – DC macro-clustering within lymph node microenvironments initiates Th2 cell differentiation in a site-specific manner

  Miranda R. Lyons-Cohen, et al., bioRxiv - Immunology 2023

  Quote: ... In some studies 100µg anti-LFA-1α (clone M17/4, BioXcell), 100µg rat IgG2a isotype control (BioXcell) ...
• Interferons and tuft cell numbers are bottlenecks for persistent murine norovirus infection

  Somya Aggarwal, et al., bioRxiv - Microbiology 2024

  Quote: ... was mixed with 25 μg anti-IL-4 (Clone 11B11, BioXCell) and incubated for 1-5 min prior to diluting to 200 μl total volume in PBS ...
• HDAC1 controls the generation and maintenance of effector-like CD8⁺ T cells during chronic viral infection

  Ramona Rica, et al., bioRxiv - Immunology 2024

  Quote: ... cells were stained with VL-4 rat anti-LCMV nucleoprotein (BioXCell), followed by staining with anti-rat horseradish peroxidase (Jackson Immunoresearch ...
• Endothelial cells are a key target of IFN-g during response to combined PD-1/CTLA-4 ICB treatment in a mouse model of bladder cancer

  Sharon L. Freshour, et al., bioRxiv - Cancer Biology 2023

  Quote: ... and 200 ug anti-CTLA-4 (BioXcell, catalog #BE0164, clone 9D9) at days 9 and 12 after organoid implantation ...
• A cancer immunotherapy modality based on dendritic cell reprogramming in vivo

  Ervin Ascic, et al., bioRxiv - Immunology 2024

  Quote: ... and/or 200 μg of anti-CTLA-4 (clone 9H10, BioXCell) or rat 200 µg IgG2a (clone 2A3 ...
• Restructuring of the Immune Contexture Improves Checkpoint Blockade Efficacy in Murine Lung Cancer

  Nancy D. Ebelt, et al., bioRxiv - Cancer Biology 2020

  Quote: ... and 75µg of anti-CTLA-4 (9H10) antibody or IgG equivalent (BioXCell). Treatments continued every three days until the end of the experiment (maximum tumor growth of 15 mm diameter for control groups) ...
• Transplantation Elicits a Clonally Diverse CD8⁺ T Cell Response that is Comprised of Potent CD43⁺ Effectors

  Gregory A. Cohen, et al., bioRxiv - Immunology 2022

  Quote: ... mice were treated with 250 ug/dose of CTLA-4 Ig (BioXCell) and anti-ICOS (BioXCell ...
• Induction of a colitogenic phenotype in Th1 cells depends on IL-23R signaling

  Mathias Pawlak, et al., bioRxiv - Immunology 2021

  Quote: ... the medium was supplemented with anti-IL-4 antibody (BioXcell; clone 11B11). On day 5 ...
• Single-cell profiling uncovers regulatory programs of pathogenic Th2 cells in allergic asthma

  Matarr Khan, et al., bioRxiv - Immunology 2023

  Quote: ... or 4-1BB (5 µg/ml, clone 3H3, BE0239) all from BioXCell. Unless otherwise stated ...
• An autophagy program that promotes T cell egress from the lymph node controls responses to immune checkpoint blockade

  Diede Houbaert, et al., bioRxiv - Immunology 2023

  Quote: ... and 100 μg monoclonal antibody to integrin αL (clone M17/4; BioXCell) and sacrificed eight hours later.
• An IL-2 mutein increases IL-10 and CTLA-4-dependent suppression of dendritic cells by regulatory T cells

  Braxton L. Jamison, et al., bioRxiv - Immunology 2023

  Quote: ... 500 µg of anti-CTLA-4 antibody (clone UC10-4F10-11, BioXCell) or hamster IgG isotype control antibody (clone PIP ...
• A multi-enhancer hub at the Ets1 locus controls T cell differentiation and allergic inflammation through 3D genome topology

  Aditi Chandra, et al., bioRxiv - Genomics 2022

  Quote: ... 10 μg/mL of anti-IL-4 (Clone: 11B11, BioXCell, Cat# BE0045), 2 ng/mL of recombinant TGFβ (BioLegend ...
• Endothelial cells are a key target of IFN-g during response to combined PD-1/CTLA-4 ICB treatment in a mouse model of bladder cancer

  Sharon L. Freshour, et al., bioRxiv - Cancer Biology 2023

  Quote: ... and/or 200 μg/mouse αCTLA-4 (BioXcell, catalog #BE0164, clone 9D9) i.p ...
• Identification of a Highly Functional Effector CD8⁺ T Cell Program after Transplantation in Mice and Humans

  Gregory S. Cohen, et al., bioRxiv - Immunology 2024

  Quote: ... mice were treated with 250 ug/dose of CTLA-4 Ig (BioXCell) and anti-CD40L (MR1 clone ...
• Cancer therapy via neoepitope-specific monoclonal antibody cocktails

  Colin J. Hartman, et al., bioRxiv - Immunology 2024

  Quote: ... and mouse anti-mouse CTLA-4 (Bio X Cell BE0164, Clone 9D9). The IgG control used in in vivo experiments was an HIV-specific antibody ...
• Identification of a Highly Functional Effector CD8⁺ T Cell Program after Transplantation in Mice and Humans

  Gregory S. Cohen, et al., bioRxiv - Immunology 2024

  Quote: ... mice were treated with 250 ug/dose of CTLA-4 Ig (BioXCell) and anti-CD40L (MR1 clone ...
• TUMOR-INFILTRATING NOCICEPTOR NEURONS PROMOTE IMMUNOSUPPRESSION

  Anthony C. Restaino, et al., bioRxiv - Cancer Biology 2024

  Quote: ... and 10 µg/ml anti-IL-4 antibody (Bio X Cell, BE0045), in a 96-well plate ...