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51 - 100 of 390 citations for 4 Hydroxy 7 trifluoromethyl quinoline 3 carbohydrazide since 2020

• Disruption of Core Stress Granule Protein Aggregates Promotes CNS Axon Regeneration

  Pabitra K. Sahoo, et al., bioRxiv - Neuroscience 2024

  Quote: ... and passaged every 6-7 days using Gentle Cell Dissociation Reagent (StemCell Technologies).
• Expansion and differentiation of ex vivo cultured erythroblasts in scalable stirred bioreactors

  Joan Sebastián Gallego-Murillo, et al., bioRxiv - Bioengineering 2022

  Quote: ... and interleukin-3 (IL-3; 1 ng/mL, first day only; Stemcell Technologies; Canada). Cell density was maintained between 0.7-2×106 cells/mL by daily feeding with fresh expansion medium.
• Base-resolution models of transcription factor binding reveal soft motif syntax

  Žiga Avsec, et al., bioRxiv - Genomics 2020

  Quote: ... 3 µM CHIR99021 (Stemcell Technologies), 1 µM PD0325901 (Stemcell Technologies) ...
• Reconstructing bat antiviral immunity using epithelial organoids

  Max J. Kellner, et al., bioRxiv - Immunology 2024

  Quote: ... + 3 µM CHIR9902 (Stemcell Technologies) + 10 µM SB-431542 (Stemcell Technologies ...
• Building functional circuits in multispecies brains

  Benjamin T. Throesch, et al., bioRxiv - Developmental Biology 2023

  Quote: ... 3 μM CHIR99021 (STEMCELL Technologies), 1 μM PD0325901 (STEMCELL Technologies) ...
• Antisense oligonucleotide targeting pathogenic sense repeat RNA in C9ORF72 suppresses production of antisense-dependent dipeptide repeat proteins implicated in ALS/FTD

  Yuanzheng Gu, et al., bioRxiv - Neuroscience 2024

  Quote: ... 3 μM CHIR99021 (StemCell Technologies), 2 μM DMH1 (StemCell Technologies) ...
• Magneto-acoustic protein nanostructures for non-invasive imaging of tissue mechanics in vivo

  Whee-Soo Kim, et al., bioRxiv - Biochemistry 2022

  Quote: ... Cells were passaged every 5-7 days using ReLeSR (STEMCELL Technologies, Vancouver, BC, Canada) and maintained within passages 20 to 50.
• Leukemia confers a durable imprint on healthy hematopoietic stem and progenitor cells

  Ding-Wen Chen, et al., bioRxiv - Cancer Biology 2024

  Quote: ... CFU assays were imaged at day 7 and 14 using STEMVision (Stem Cell Technologies).
• Use of Induced Pluripotent Stem Cells to Build Isogenic Systems and Investigate Type 1 Diabetes

  Lucas H. Armitage, et al., bioRxiv - Immunology 2021

  Quote: ... and 3 mM CHIR (StemCell Technologies)) ...
• Endogenous suppression of WNT signalling in human embryonic stem cells leads to low differentiation propensity towards definitive endoderm

  Dominika Dziedzicka, et al., bioRxiv - Cell Biology 2020

  Quote: ... 3 µM CHIR99021 (CHIR, STEMCELL Technologies) and 100 ng/mL Activin A (Biotechne) ...
• Circadian regulation of lung repair and regeneration

  Amruta Naik, et al., bioRxiv - Cell Biology 2021

  Quote: ... CHIR99021 3 µm (72052 StemCell Technologies), DMSO (final concentration 0.05% ...
• Chromatin Profiling of CBFA2T3-GLIS2 AMLs Identifies Key Transcription Factor Dependencies and BRG1 Inhibition as a Novel Therapeutic Strategy

  Samantha Kaonis, et al., bioRxiv - Cancer Biology 2023

  Quote: ... + 10ng/ml IL-3 (STEMCELL Technologies). The WSU-AML cell line was also seeded at 1x106 cells/ml ...
• Use of Stem Cell-Derived Cardiomyocyte and Nasal Epithelium Models to Establish a Multi-Tissue Model Platform to Validate Repurposed Drugs Against SARS-CoV-2 Infection

  Nathan J Gödde, et al., bioRxiv - Microbiology 2024

  Quote: ... Cells were incubated for 7 days submerged in PneumaCult-ExPlus (STEMCELL Technologies, Vancouver, BC, Canada). After the 7-day culture ...
• CHRFAM7A overexpression in human iPSC-derived Interneurons dysregulates α7- nAChR surface expression and alters response to oligomeric β-amyloid peptide

  Maria Llach Pou, et al., bioRxiv - Neuroscience 2024

  Quote: ... from day 0 to day 7 and with 100 nM LDN193189 (ref.72147, Stemcell Technologies) from day 7 to day 14 ...
• In vivo Targeting MEK and TNK2/SRC pathways in PTPN11 driven leukemia

  Bill H. Chang, et al., bioRxiv - Cancer Biology 2024

  Quote: ... Cells were visualized at day 7 or 14 using the STEMVision colony counter (STEMCELL Technologies) with manual counting to ensure accuracy.
• Development of optimised human iPSC-derived hepatocytes with improved liver function for in vitro metabolic disease modelling and toxicity studies

  Magdalena Łukasiak, et al., bioRxiv - Cell Biology 2024

  Quote: ... and cells were passaged every 5-7 days using ReleSR (#100-0483; STEMCELL Technologies, Cambridge, UK).
• Polycomb contraction differentially regulates terminal human hematopoietic differentiation programs

  A. Lorzadeh, et al., bioRxiv - Cell Biology 2020

  Quote: ... and 3 units/mL EPO (STEMCELL Technologies) in the presence of 1 µM GSK-J4 (Sigma ...
• Enhanced donor heart preservation by therapeutic inhibition of acid sensing ion channel 1a

  Meredith A. Redd, et al., bioRxiv - Physiology 2020

  Quote: ... containing 3 μM CHIR99021 (Stem Cell Technologies), 500 μg/mL BSA (Sigma Aldrich) ...
• Human bone marrow organoids for disease modelling, discovery and validation of therapeutic targets in hematological malignancies

  Abdullah O. Khan, et al., bioRxiv - Cancer Biology 2022

  Quote: ... Interleukin-3 (IL3, StemCell Technologies, Cat#78194) and Interleukin-6 (IL6 ...
• Structurally and functionally distinct early antibody responses predict COVID-19 disease trajectory and mRNA vaccine response

  Saborni Chakraborty, et al., bioRxiv - Immunology 2021

  Quote: ... anti-CD32 (STEMCELL Technologies; clone IV.3), anti-CD32B/C (clone S18005H) ...
• IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition

  Caterina Prelli Bozzo, et al., bioRxiv - Microbiology 2020

  Quote: ... CHIR 99021 3 µM (Stemcell Technologies, 72054), Pumorphamine 1 µM (Miltenyi Biotec ...
• Modeling lung cell development using human pluripotent stem cells

  Shuk Yee Ngan, et al., bioRxiv - Developmental Biology 2021

  Quote: ... 3 µM CHIR99021 (STEMCELL Technologies, cat#72054), 100 nM All-trans Retinoic acid (ATRA ...
• Cell cycle gene regulation dynamics revealed by RNA velocity and deep-learning

  Andrea Riba, et al., bioRxiv - Systems Biology 2021

  Quote: ... 3 µM CHIR99021 (72054, Stem Cell Technologies) and 1 µM PD0325901 (72184 ...
• Reticular Dysgenesis-associated Adenylate Kinase 2 deficiency causes failure of myelopoiesis through disordered purine metabolism

  Wenqing Wang, et al., bioRxiv - Cell Biology 2021

  Quote: ... 100μg/mL hrIL-3 (StemCell Technologies 78040), 10μg/mL hrG-CSF (NEUPOGEN ...
• Soluble NS1 antagonizes IgG- and IgA-mediated monocytic phagocytosis of DENV infected cells

  Mitchell J. Waldran, et al., bioRxiv - Immunology 2022

  Quote: ... -32 (Stemcell Technologies 60012 clone IV.3), or -64 (Biolegend 305002 Clone 10.1).
• MAPT expression is mediated by long-range interactions with cis-regulatory elements

  Brianne B. Rogers, et al., bioRxiv - Genomics 2023

  Quote: ... 10 µg/mL NT-3 (StemCell Technologies), and 1 mg/mL Mouse Laminin (Gibco) ...
• Differentiation of airway cholinergic neurons from human pluripotent stem cells for airway neurobiology studies

  P.A. Goldsteen, et al., bioRxiv - Neuroscience 2022

  Quote: ... and 3 µM CHIR99021 (STEMCELL Technologies, 72054), was freshly added ...
• Engineering human spinal microphysiological systems to model opioid-induced tolerance

  Hongwei Cai, et al., bioRxiv - Bioengineering 2022

  Quote: ... and 3 μM CHIR-99021 (Stemcell Technologies). After 4-day culture in SCM I ...
• Regulation of Store-Operated Ca²⁺ Entry by IP₃ Receptors Independent of Their Ability to Release Ca²⁺

  Pragnya Chakraborty, et al., bioRxiv - Cell Biology 2023

  Quote: ... CHIR99021 (3 μM, STEMCELL Technologies, Cat#72052), purmorphamine (0.5 mM ...
• Identification of small molecule agonists of fetal hemoglobin expression for the treatment of sickle cell disease

  Jian-Ping Yang, et al., bioRxiv - Cell Biology 2024

  Quote: ... and 3 U/mL heparin (StemCell Technologies) for differentiating progenitor cells into erythrocytes.
• GATA6 regulates WNT and BMP programs to pattern precardiac mesoderm during the earliest stages of human cardiogenesis

  Joseph A Bisson, et al., bioRxiv - Developmental Biology 2024

  Quote: ... 3 μM CHIR99021 (Stem Cell Technologies 72054) was included in the “Day 0 medium” and/or the concentration of BMP4 was reduced to 5 ng/mL (Figure 6C-E ...
• Fetal Liver-like Organoids Recapitulate Blood-Liver Niche Development and Multipotent Hematopoiesis from Human Pluripotent Stem Cells

  Milad Rezvani, et al., bioRxiv - Developmental Biology 2024

  Quote: ... 50 ng/ml IL-3 (STEMCELL Technologies), 50 ng/ml IL-34 (Biolegend) ...
• The temporal balance between self-renewal and differentiation of human neural stem cells requires the Amyloid Precursor Protein

  Khadijeh Shabani, et al., bioRxiv - Neuroscience 2021

  Quote: ... Cultures were fed every other day and passaged every 5–7 days by ReLeSR™ (STEMCELL Technologies).
• Label-free and high-throughput removal of residual undifferentiated cells from iPSC-derived spinal-cord progenitor cells

  Tan Dai Nguyen, et al., bioRxiv - Bioengineering 2023

  Quote: ... The iPSCs were routinely passaged every 5-7 days using ReLeSR™ Passaging Reagent (Stemcell Technologies, Canada). The iPSCs were then differentiated into SCPCs based on a modified protocol to generate spinal motor neurons (Hor et al. ...
• An arrayed CRISPR/Cas9 screen identifies mTORC1 as a regulator of lipid droplet accumulation in APOE E3 and APOE KO iPSC-derived microglia

  Sonja Meier, et al., bioRxiv - Neuroscience 2024

  Quote: ... embryonic bodies (EBs) were formed for 7 days in mTeSR plus medium in AggreWell plates (Stemcell Technologies) with addition of human recombinant BMP-4 (50 ng/ml ...
• Droplet based low input proteomic platform for rare cell populations

  Matthew Waas, et al., bioRxiv - Biochemistry 2023

  Quote: ... Cells were cultured for 7 d at 5% O2 in EpiCult- B mouse medium (STEMCELL Technologies, 05610) supplemented with 5% FBS ...
• Chemokine profiling of melanoma-macrophage crosstalk identifies CCL8 and CCL15 as prognostic factors in cutaneous melanoma

  Celia Barrio-Alonso, et al., bioRxiv - Cancer Biology 2023

  Quote: ... for 5-7 days and embedded into 2 mg/ml collagen type-I (StemCell Technologies, Vancouver, Canada) gels ...
• miR126-mediated impaired vascular integrity in Rett syndrome

  Tatsuya Osaki, et al., bioRxiv - Cell Biology 2024

  Quote: ... for the first day after passages and subcultured every 5–7 days using ReLeSR reagent (STEMCELL Technologies). The pluripotency of iPS cells were characterized by immunostaining with OCT3/4 ...
• SARS-CoV-2 and Malayan pangolin coronavirus infect human endoderm, ectoderm and induced lung progenitor cells

  Bixia Hong, et al., bioRxiv - Microbiology 2020

  Quote: ... anti-SSEA-4 antibody (STEMCELL Technologies), anti-Sox17 antibody (R&D System) ...
• MLL1 directs gut-associated antibody responses to helminth and bacterial infections

  Yan Zhang, et al., bioRxiv - Immunology 2024

  Quote: ... 50ng/ml IL-4 (STEMCELL Technologies), 5ng/ml IL-5 (R&D Systems) ...
• Macrolide resistance through uL4 and uL22 ribosomal mutations in Pseudomonas aeruginosa

  Lise Goltermann, et al., bioRxiv - Microbiology 2024

  Quote: ... 4 µg/mL heparin (STEMCELL Technologies), Pneumacult-ALI maintenance supplement (STEMCELL Technologies ...
• Electromembrane extraction and mass spectrometry for liver organoid drug metabolism studies

  Frøydis Sved Skottvoll, et al., bioRxiv - Biochemistry 2020

  Quote: ... containing 3 μM CHIR99021 (STEMCELL Technologies, Vancouver, Canada), 50 nM PI-103 from Bio-Techne Ltd ...
• Leveraging complex interactions between signaling pathways involved in liver development to robustly improve the maturity and yield of pluripotent stem cell-derived hepatocytes

  Claudia Raggi, et al., bioRxiv - Developmental Biology 2020

  Quote: ... and 3 μM CHIR-99021 (Stem Cell Technologies), and then for the 3 following days to 100 ng/ml Activin A alone ...
• An unconventional mechanism of IL-1β secretion that requires Type I IFN in lupus monocytes

  Simone Caielli, et al., bioRxiv - Immunology 2023

  Quote: ... Human Peripheral Blood Plasma (3%; Stem Cell Technologies), 3,3‘,5-Triiodo-L-thyronine (1 µM ...
• High-content fluorescence bioassay to investigate pore formation, ion channel modulation and cell membrane lysis induced by venoms

  Simon Kramer, et al., bioRxiv - Pharmacology and Toxicology 2023

  Quote: ... containing 3 μM CHIR99021 (Stem Cell Technologies, Canada), 500 μg.mL-1 bovine serum albumin (BSA ...
• Differentiation of airway cholinergic neurons from human pluripotent stem cells for airway neurobiology studies

  P.A. Goldsteen, et al., bioRxiv - Neuroscience 2022

  Quote: ... 3 µM CHIR99021 (STEMCELL Technologies, Vancouver, Canada, 72054), and 1 µM retinoic acid ...
• Early nuclear phenotypes and reactive transformation in human iPSC-derived astrocytes from ALS patients with SOD1 mutations

  Vincent Soubannier, et al., bioRxiv - Neuroscience 2023

  Quote: ... 3 μM CHIR99021 (STEMCELL Technologies; Cat. No. 72054), 2 μM DMH1 (Sigma-Aldrich ...
• A novel isoform of Tensin1 promotes actin filament assembly for efficient erythroblast enucleation

  Arit Ghosh, et al., bioRxiv - Cell Biology 2024

  Quote: ... 1 ng/mL IL-3 (STEMCELL Technologies, 78040) and 1% Penicillin-Streptomycin (Gibco 15140122) ...
• DDX41 dissolves G-quadruplexes to maintain erythroid genome integrity and prevent cGAS-mediated cell death

  Honghao Bi, et al., bioRxiv - Cancer Biology 2024

  Quote: ... and Interleukin-3 (IL3, StemCell Technologies, Cat#78194) and Interleukin-6 (IL6 ...
• The Endoplasmic Reticulum Proteostasis Regulator ATF6 is Essential for Human Cone Photoreceptor Development

  Heike Kroeger, et al., bioRxiv - Developmental Biology 2020

  Quote: ... and pluripotent stem cells were passaged every 5 to 7 days in the ReLeSR medium (Stem Cell Technologies). Pluripotent iPSC and hESC were differentiated into retinal organoids as previously described (9 and Fig S1 ...