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101 - 108 of 108 citations for IFN alpha 2a Human since 2019

• Mitochondrial protein import stress augments α-synuclein aggregation and neurodegeneration independent of bioenergetics

  Liam P. Coyne, et al., bioRxiv - Molecular Biology 2023

  Quote: ... male Slc25a4 p.A114P,A123D/+ mice were crossed with female C57BL/6 mice with transgenic expression of the human SNCA gene (coding for the α-synuclein protein) harboring the pathogenic A53T mutation (Jackson Lab #006823) 29 ...
• Multiple phosphatidylinositol(3)phosphate roles in retinal pigment epithelium membrane recycling

  Feng He, et al., bioRxiv - Cell Biology 2020

  Quote: ... and transgenic mice that express Cre recombinase under control of the human bestrophin-1 (BEST1) promoter (C57BL/6-Tg(BEST1-cre)1Jdun/J) (Iacovelli et al, 2011) were purchased from Jackson lab (Bar Harbor, ME). CD-1 IGS mice were purchased from Charles River (Wilmington ...
• DNMT3A harboring leukemia-associated mutations directs sensitivity to DNA damage at replication forks

  Kartika Venugopal, et al., bioRxiv - Cancer Biology 2021

  Quote: ... A knock-in mouse line that conditionally expresses Dnmt3aR878H allele (equivalent to DNMT3AR882H in humans) from the endogenous locus (Jackson Laboratory stock No. 031514) was described13 ...
• Lack of Adipocyte Purinergic P2Y₆ Receptor Greatly Improves Whole Body Glucose Homeostasis

  Shanu Jain, et al., bioRxiv - Physiology 2020

  Quote: ... we crossed P2Y6R-floxed mice with mice expressing recombinase under the control of human skeletal actin promoter (HSA-Cre 79; Jackson Laboratories (Stock No. 006149); genetic background ...
• Targeting CD19 for the treatment of B-cell related autoimmune diseases with a novel T cell engager

  Andy Qingan Yuan, et al., bioRxiv - Immunology 2024

  Quote: ... the cells were washed twice with FACS buffer and stained with Alexa Fluor 488-conjugated goat-anti human IgG Fc antibody (Jackson Laboratory, 109-545-098). The binding of mouse anti-human CD3 (clone ...
• PNMA2 forms non-enveloped virus-like capsids that trigger paraneoplastic neurological syndrome

  Junjie Xu, et al., bioRxiv - Neuroscience 2023

  Quote: ... The membrane was washed by TBS and then incubated with secondary antibodies (anti-mouse IgG, anti-rat IgG, anti-human IgG, Jackson Laboratory, Bar Harbor, ME; 1:5000) diluted by 1% milk in TBS for 1h at room temperature ...
• Dual-specificity protein phosphatase 6 (DUSP6) overexpression reduces amyloid load and improves memory deficits in male 5xFAD mice

  Allen L. Pan, et al., bioRxiv - Neuroscience 2023

  Quote: ... familial AD (FAD) mutations and human Presenilin1 (PS1) with the M146L and L286V FAD mutations [18] were purchased from Jackson Labs (Bar Harbor, ME; JAX#34840) and were maintained on a mixed B6/SJL genetic background as described [19] ...
• Kif11 overexpression rescues cognition, long-term potentiation, and spine defects in mouse and cell models of Alzheimer’s disease

  Esteban M. Lucero, et al., bioRxiv - Neuroscience 2021

  Quote: ... and London: V717I) and two mutations in human PSEN1 (M146L and L286V) (Oakley et al., 2006) were obtained from Jackson Labs (JAX MMRRC Stock No: 34848-JAX). These mice were used to establish an in-house breeding colony in which 5xFAD mice were bred to fully congenic WT C57Bl/6J mice obtained from Jackson labs (Jax Stock Number ...