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3851 - 3900 of 10000+ citations since 2019

• TgLaforin, a glucan phosphatase, reveals the dynamic role of storage polysaccharides in Toxoplasma gondii tachyzoites and bradyzoites

  Robert D. Murphy, et al., bioRxiv - Microbiology 2023

  Quote: 4- to 6-week old CBA/J mice of both sexes (Jackson Laboratories, Bar Harbor, ME) were injected intraperitoneally (i.p. ...
• Rtf1-dependent transcriptional pausing regulates cardiogenesis

  Adam D. Langenbacher, et al., bioRxiv - Developmental Biology 2023

  Quote: ... This line was then crossed to a ROSA26::FLPe strain54 (The Jackson Laboratory, JAX stock #009086) to create an Rtf1 conditional knockout allele where exon 3 of Rtf1 is flanked by two loxP sites (Rtf1flox) ...
• The DNA helicase FANCJ (BRIP1) functions in Double Strand Break repair processing, but not crossover formation during Prophase I of meiosis in male mice

  Tegan S. Horan, et al., bioRxiv - Genetics 2023

  Quote: All moue strains were backcrossed at least two generations and maintained on a C57BL/6J background (Jackson Laboratory). Mice were housed in polysulfone cages on ventilated racks (Allentown PC75JHT) ...
• Regional random mutagenesis driven by multiple sgRNAs and diverse on-target genome editing events to identify functionally important elements in non-coding regions

  Kento Morimoto, et al., bioRxiv - Genetics 2023

  Quote: An ICR outbred strain was purchased from Jackson Laboratory Japan ...
• Gait speed is a biomarker of cancer-associated cachexia decline and recovery

  Ishan Roy, et al., bioRxiv - Cancer Biology 2023

  Quote: ... Male C57BL/6J mice were obtained from Jackson laboratory (Bar Harbor, ME, USA). At 12 weeks old ...
• De novo lipogenesis pathway is a vulnerability in IDH1 mutant glioma

  Lubayna S Elahi, et al., bioRxiv - Cancer Biology 2023

  Quote: ... Strains: 8 to 12-week-old NOD-SCID gamma null (NSG) mice (NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ Jackson Laboratory, 00557) were used to generate tumors from a patient-derived glioma line BT142 ...
• The Myc-Like Mlx Network Impacts Aging and Metabolism

  Huabo Wang, et al., bioRxiv - Cancer Biology 2023

  Quote: ... Balance was measured using a Rotarod apparatus (SPW Industrial, Laguna Hills, CA) and a modification of the procedure provided by Jackson Laboratories (Bar Harbor, ME) as described previously (23) ...
• Single-cell profiling reveals the impact of genetic alterations on the differentiation of inflammation-induced colon tumors

  Ahmed H. Ghobashi, et al., bioRxiv - Cancer Biology 2023

  Quote: ... Msh2l/lVC are a result of crossing B6.Cg-MSH2tm2.1Rak/J (The Jackson Laboratory; RRID:IMSR_JAX:016231) and B6.Cg-Tg(Vil1-cre ...
• A Novel Imaging Method (FIM-ID) Reveals that Myofibrillogenesis Plays a Major Role in the Mechanically Induced Growth of Skeletal Muscle

  Kent W. Jorgenson, et al., bioRxiv - Cell Biology 2023

  Quote: Experimental procedures were performed on male C57BL/6J mice (Jackson Laboratories) that were 8–10 weeks of age ...
• Development of adaptive anoikis resistance promotes metastasis that can be overcome by CDK8/19 Mediator kinase inhibition

  Mehri Monavarian, et al., bioRxiv - Cancer Biology 2023

  Quote: ... 8-week-old NOD.Cg-Prkdcscid/J (SCID, Jackson labs) mice were randomized ...
• Development of adaptive anoikis resistance promotes metastasis that can be overcome by CDK8/19 Mediator kinase inhibition

  Mehri Monavarian, et al., bioRxiv - Cancer Biology 2023

  Quote: SNX631 study: Twenty-four 8 weeks old NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG from Jackson labs) mice were randomized into 2 groups receiving either control or SNX631-6 medicated diet (350 ppm ...
• Anesthetic oxygen use and sex are critical factors in the FLASH sparing effect

  Armin D. Tavakkoli, et al., bioRxiv - Cancer Biology 2023

  Quote: ... were acquired from Jackson Laboratories and allowed to acclimate for at least 3 days ...
• The anti-B7-H3 blocking antibody MJ18 does not recognize B7-H3 in murine tumor models

  Talah Nammor, et al., bioRxiv - Cancer Biology 2023

  Quote: C57BL/6 mouse were purchased from Jackson Laboratory. All animals were housed under standard conditions (21 – 22 °C ...
• A Mutation-driven oncofetal regression fuels phenotypic plasticity in colorectal cancer

  Slim Mzoughi, et al., bioRxiv - Cancer Biology 2023

  Quote: ... The equivalent of 5x105 cells was injected subcutaneously in both flanks of 7 to 8-week-old female NSG mice (Strain #:005557, Jackson Laboratory). Tumor dimensions were measured using calipers and volume was calculated as 0.5x(Length x width2) ...
• A novel druggable DYRK3/CAMKV signaling module for Neuroblastoma tumor growth inhibition

  Esteban J. Rozen, Kim Wgglesworth, Jason Shohet, bioRxiv - Cancer Biology 2023

  Quote: One million Tet-shDYRK3 JF cells suspended in 0.1 ml of PBS were surgically implanted in the left renal capsule of NSG immunodeficient mice (The Jackson Laboratory #005557). After days ...
• A nonenzymatic dependency on inositol-requiring enzyme 1 controls cancer cell cycle progression and tumor growth

  Iratxe Zuazo-Gaztelu, et al., bioRxiv - Cancer Biology 2023

  Quote: ... All secondary antibodies were from Jackson Laboratories. The primary antibodies are listed in the Table below.
• HDAC10 blockade upregulates SPARC expression thereby repressing melanoma cell growth and BRAF inhibitor resistance

  Hongbo Ling, et al., bioRxiv - Cancer Biology 2023

  Quote: ... control and HDAC10 knockdown A375 cells (1×106 in 100 μl PBS) were subcutaneously injected into the flanks of NSG mice at the age of 6–8 weeks (Jackson Laboratory, RRID:IMSR_JAX:005557). The mice were sacrificed 3 weeks after injection and the tumor weight was measured ...
• Targeting YAP mechanosignaling to ameliorate stiffness-induced Schlemm’s canal cell pathobiology

  Haiyan Li, et al., bioRxiv - Cell Biology 2023

  Quote: ... Nine C57BL/6J mice (both male and female, 3-6 months-old; Jackson Laboratory, Bar Harbor, ME, USA) were used for the study ...
• Paternally-induced environmental programming of placenta development, offspring birth weight and health phenotypes in a mouse model

  Elaine Chen, et al., bioRxiv - Developmental Biology 2023

  Quote: ... The Ogttm1Gwh mice were obtained from Jackson laboratories (Strain #:004860) and have a B6.129 (C57BL/6 ...
• Mitochondrial One-Carbon Metabolism is Required for TGF-β-Induced Glycine Synthesis and Collagen Protein Production

  Angelo Y. Meliton, et al., bioRxiv - Cell Biology 2023

  Quote: ... Male C57Bl/6J mice (8- 12 weeks old; Jackson Laboratory) were intubated and bleomycin (0.7U/kg ...
• Programmed withdrawal of cilia maintenance followed by centriole capping leads to permanent cilia loss during cerebellar granule cell neurogenesis

  Sandii Constable, et al., bioRxiv - Cell Biology 2023

  Quote: ... CD1 mice were purchased from Jackson Labs and maintained under standard conditions ...
• Engrailed transcription factors direct excitatory cerebellar neuron diversity and survival

  Anjana Krishnamurthy, et al., bioRxiv - Developmental Biology 2023

  Quote: ... 2007), En2lox(Cheng et al., 2010), Atoh1-Cre (Matei et al., 2005), R26LSL-ntdTom(Quina et al., 2017)(Ai75D, Jackson Labs, stock no: 025106), Selenow-Cre (Gerfen et al. ...
• Microsomal triglyceride transfer protein is necessary to maintain lipid homeostasis and retinal function

  Catharina R. Grubaugh, et al., bioRxiv - Cell Biology 2023

  Quote: ... 017557) (29) which were purchased from Jackson Laboratories (Bar Harbor, ME, USA). Two-generation crosses were used to produce mice that were Mttpflox/floxand Cre transgenic (Mttpflox/flox ...
• Beneficial effects of intermittent fasting in NASH and subsequent HCC development are executed by concerted PPARα and PCK1 action in hepatocytes

  Suchira Gallage, et al., bioRxiv - Cancer Biology 2023

  Quote: ... The GRfl/fl mice in C57BL6/J background were purchased from Jackson Laboratories. The GRfl/fl mice were then crossed with Alb-cre mice to generate hepatocyte-specific GR knockout mice (GRHEP) ...
• Tumor microenvironment-induced FOXM1 regulates ovarian cancer stemness

  Chiara Battistini, et al., bioRxiv - Cancer Biology 2023

  Quote: ... Cells were then washed with PBS and incubated with the Alexa Fluor-conjugated secondary antibodies (Jackson Laboratories) for 1 hour at room temperature ...
• IRF8-mutant B cell lymphoma evades immunity through a CD74-dependent deregulation of antigen processing and presentation in MHC CII complexes

  Zhijun Qiu, et al., bioRxiv - Cancer Biology 2023

  Quote: ... A local colony of TCR (Vα2, Vβ5) transgenic mice (OT-I) (Strain #:003831, Jackson Laboratories) was maintained by breeding homozygous transgenic mice ...
• IRF8-mutant B cell lymphoma evades immunity through a CD74-dependent deregulation of antigen processing and presentation in MHC CII complexes

  Zhijun Qiu, et al., bioRxiv - Cancer Biology 2023

  Quote: Spleens were collected from 8- 12 week old TCR (Vα2, Vβ5) transgenic mice (OT-I) (Strain #:003831, Jackson Laboratories) and T lymphocytes purified using Easy SepTM Mouse T cell isolation kit (STEMCELL Technologies ...
• Enzalutamide Induces Cytotoxicity in Desmoplastic Small Round Cell Tumor Independent of the Androgen Receptor

  Justin W. Magrath, et al., bioRxiv - Cancer Biology 2023

  Quote: ... Male or Female NOD-SCID-IL2Rγ-null (NSG) mice (6 weeks) were purchased (Jackson Laboratory, Bar Harbor, ME) and used for all xenograft studies ...
• Colon cancer arises from differentiated cell lineages in the context of inflammation

  Mathijs P. Verhagen, et al., bioRxiv - Cancer Biology 2023

  Quote: ... mice were crossed with R26LSL-YFP mice (#006148, Jackson Laboratories) or R26LSL-tdTomato mice (#007908 ...
• Colon cancer arises from differentiated cell lineages in the context of inflammation

  Mathijs P. Verhagen, et al., bioRxiv - Cancer Biology 2023

  Quote: ... or R26LSL-tdTomato mice (#007908, Jackson Laboratories). To target specific mutations in PCs ...
• Colon cancer arises from differentiated cell lineages in the context of inflammation

  Mathijs P. Verhagen, et al., bioRxiv - Cancer Biology 2023

  Quote: ... the above strains were further crossed with Apc15lox (#029275, Jackson Laboratories)(12) ...
• Colon cancer arises from differentiated cell lineages in the context of inflammation

  Mathijs P. Verhagen, et al., bioRxiv - Cancer Biology 2023

  Quote: The following inducible Cre strains encompassing were employed: Lgr5CreERT2-EGFP (#008875, Jackson Lab(15)) and pLysCreERT2 (kind gift from the Clevers Lab(16)) ...
• Colon cancer arises from differentiated cell lineages in the context of inflammation

  Mathijs P. Verhagen, et al., bioRxiv - Cancer Biology 2023

  Quote: ... and Trp53flox (#008462, Jackson Laboratories)(14) ...
• Co-regulator activity of Mediator of DNA Damage Checkpoint 1 (MDC1) is associated with DNA repair dysfunction and PARP inhibitor sensitivity in lobular carcinoma of the breast

  Joseph L. Sottnik, et al., bioRxiv - Cancer Biology 2023

  Quote: ... 6-8 week female NSG (NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ; Jackson Laboratory strain 005557) mice were used for all experiments ...
• Glomerular immune injury promotes anti-tumor activity

  Shimrit Avraham, et al., bioRxiv - Cancer Biology 2023

  Quote: Age-matched C57BL/6J male mice were purchased from Jackson Laboratory and injected i.v ...
• Autophagy regulates tumor growth and metastasis

  Lei Qiang, et al., bioRxiv - Cancer Biology 2023

  Quote: ... K14-Cre mice were obtained from Jackson Laboratories and Atg7flox/flox mice were kindly provided by Masaaki Komatsu (Tokyo Metropolitan Institute of Medical Science ...
• Enzalutamide Induces Cytotoxicity in Desmoplastic Small Round Cell Tumor Independent of the Androgen Receptor

  Justin W. Magrath, et al., bioRxiv - Cancer Biology 2023

  Quote: ... Male NOD (SCID)-IL-2Rgnull mice (The Jackson Laboratory; Farmington, CT) were subcutaneously injected with PDX explants (2 mm ...
• Loss of function of Atrx leads to activation of alternative lengthening of telomeres in a primary mouse model of sarcoma

  Matthew Pierpoint, et al., bioRxiv - Cancer Biology 2023

  Quote: ... were crossed with CAST/EiJ mice from Jackson labs (Strain 000928). The mice generated from these crosses were then bred on a pure CAST/EiJ background for five generations ...
• Loss of function of Atrx leads to activation of alternative lengthening of telomeres in a primary mouse model of sarcoma

  Matthew Pierpoint, et al., bioRxiv - Cancer Biology 2023

  Quote: Mice of mixed background (129SVJ/C57/Bl6) with Rosa26-1loxp-Cas9 and with mTR-/- (B6.Cg-Terctm1Rdp/J; Jackson Labs 004132) were crossed with CAST/EiJ mice from Jackson labs (Strain 000928) ...
• A Germline Point Mutation in the MYC-FBW7 Phosphodegron Initiates Hematopoietic Malignancies

  Brian Freie, et al., bioRxiv - Cancer Biology 2023

  Quote: ... B6.SJL-Ptprca Pepcb/BoyJ mice (Jackson laboratories), which express the CD45.1 variant of the Ptprc gene were used as a source of competitor cells and donor mice for competitive repopulation analysis.
• Molecular and phenotypic blueprint of the hematopoietic compartment reveals proliferation stress as a driver of age-associated human stem cell dysfunctions

  Emanuele Lettera, et al., bioRxiv - Cell Biology 2023

  Quote: ... Aged match female NSG mice (NOD.Cg PrkdcscidIl2rgtm1Wjl /SzJ; Jackson Laboratory) 10-12 weeks of age were sublethally irradiated with 225 rads 1 day before intrafemoral injection ...
• CDK6-mediated endothelial cell cycle acceleration drives arteriovenous malformations in hereditary hemorrhagic telangiectasia

  Sajeth Dinakaran, et al., bioRxiv - Cell Biology 2023

  Quote: ... were obtained from the MMRRC via The Jackson Laboratory (#066960) and crossed with R26-M2rtTA mice (The Jackson Laboratory, #006965). To induce H2B-FT expression ...
• Pathological beige remodeling induced by cancer cachexia depends on the disease severity and involves mainly the trans-differentiation of mature white adipocytes

  Kaltinaitis B N H Santos, et al., bioRxiv - Cell Biology 2023

  Quote: Eight-week-old male C56BL/6 (Jackson laboratory # 000664), (wild type ...
• Trogocytosis of cancer-associated fibroblasts promotes pancreatic cancer growth and immune suppression via phospholipid scramblase anoctamin 6 (ANO6)

  Charline Ogier, et al., bioRxiv - Cancer Biology 2023

  Quote: ... C57BL/6J mice were purchased from Jackson Laboratory and maintained at the FCCC Animal Facility ...
• Following the p63/Keratin5 Basal Cells in the Sensory and Non-sensory Epithelia of The Vomeronasal Organ

  Noah M. LeFever, et al., bioRxiv - Developmental Biology 2023

  Quote: ... Strain No: 007909) were purchased from Jackson Lab. Mice of either sex were used for immunohistochemistry and immunofluorescence experiments ...
• Disulfiram reduces atherosclerosis and enhances efferocytosis, autophagy, and atheroprotective gut microbiota in hyperlipidemic mice

  C. Alicia Traughber, et al., bioRxiv - Cell Biology 2023

  Quote: ... C57BL/6J-apoE-/- mice were purchased from Jackson Laboratories and bred in house ...
• ROCK1 activates mitochondrial fission leading to oxidative stress and muscle atrophy

  Meijun Si, et al., bioRxiv - Cell Biology 2023

  Quote: ... Ten-week-old C57BL/6 mice or PhaMexcised Dentra-2 transgenic mice (Jackson Laboratory, Bar Harbor, MN) were used to create a CKD-induced muscle wasting model as previously described 45 ...
• ROCK1 activates mitochondrial fission leading to oxidative stress and muscle atrophy

  Meijun Si, et al., bioRxiv - Cell Biology 2023

  Quote: ... Mice with muscle-specific constitutive ROCK1 activation were generated by breeding caROCK1 f/f transgenic mice (which carry a floxed transcriptional stop cassette upstream of the constitutively active ROCK1 gene) 21 with mice expressing doxycycline-inducible actin promoter-driven Cre recombinase (ATCA1-Cre, Jackson Laboratory), following the breeding strategy described previously 26 ...
• Targeting EIF4A triggers an interferon response to synergize with chemotherapy and suppress triple-negative breast cancer

  Na Zhao, et al., bioRxiv - Cancer Biology 2023

  Quote: ... 200,000 tumor cells were transplanted into the 4th mammary fat pad of 6-8-week-old female BALB/c mice or C57BL/6 mice (Jackson Laboratory #000664), respectively ...
• Circadian regulation of MGMT expression and promoter methylation underlies daily rhythms in TMZ sensitivity in glioblastoma

  Maria F. Gonzalez-Aponte, et al., bioRxiv - Cancer Biology 2023

  Quote: ... or C57BL/6J (The Jackson Laboratory, Strain #000664) for murine models ...