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• Microglial adipose triglyceride lipase regulates neuroinflammatory and behavioural responses to LPS

  Josephine Louise Robb, et al., bioRxiv - Neuroscience 2023

  Quote: ... pre-treatment medium was replaced with DMEM (5 mM glucose) containing Orlistat (50 µM; MedChemExpress), ATGListatin (50 µM ...
• Decryption of sequence, structure, and functional features of SINE repeat elements in SINEUP non-coding RNA–mediated post-transcriptional gene regulation

  Harshita Sharma, et al., bioRxiv - Molecular Biology 2023

  Quote: ... cells were gently washed with 1× PBS and treated with 150 µL 1× PBS (control) or 1 mg/mL Amotosalen (MedChemExpress, HY-107004A) crosslinking solution added to each well of the 6-well plates ...
• Omicron Spike confers enhanced infectivity and interferon resistance to SARS-CoV-2 in human nasal tissue

  Guoli Shi, et al., bioRxiv - Microbiology 2023

  Quote: ... incyclinide (MedChemExpress; HY-13648), apratastat (MedChemExpress ...
• Cholinergic activation of corticofugal circuits in the adult mouse prefrontal cortex

  Allan T. Gulledge, bioRxiv - Neuroscience 2023

  Quote: ... SR-95531 (gabazine) was purchased from MedChemExpress and dissolved in DMSO for stock solutions.
• Attenuating amyloid-beta pathology in mice with in situ programmed astrocytes

  Lun Zhang, et al., bioRxiv - Neuroscience 2023

  Quote: ... and 5ng/ml HBEGF (MedChemExpress, #HY-P7400). For microglia isolation ...
• Kinetics and efficacy of antibody drug conjugates in 3D tumour models

  Chloe S Palma Chaundler, et al., bioRxiv - Biochemistry 2023

  Quote: ... were obtained from Medchemexpress, and the primary antibody ...
• Structural insights into TRPV4-Rho GTPase signaling complex function and disease

  Do Hoon Kwon, et al., bioRxiv - Biophysics 2023

  Quote: ... sample was incubated with 20 μM GSK2798745 (GSK279; Medchemexpress). For the GSK101-hTRPV4-RhoA ...
• BAZ2A-RNA mediated association with TOP2A and KDM1A represses genes implicated in prostate cancer

  Marcin Roganowicz, et al., bioRxiv - Molecular Biology 2023

  Quote: ... or OG-L002 (MedChemExpress) were added directly to the medium to a final 10 μM concentration ...
• Template-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders

  Yen-Der Li, et al., bioRxiv - Biochemistry 2023

  Quote: ... and MLN4924 (HY-70062) were obtained from MedChemExpress; MLN7243 (CT-M7243 ...
• Inducible mismatch repair streamlines forward genetic approaches to target identification of cytotoxic small molecules

  Thu P Nguyen, et al., bioRxiv - Biochemistry 2023

  Quote: MLN-4924 (HY-70062) was purchased from MedChemExpress. AZ9482 (SYN-3046 ...
• Uncovering the hidden threat: single-organoid analysis reveals clinically relevant treatment-resistant and invasive subclones in pancreatic cancer

  Maxim Le Compte, et al., bioRxiv - Cancer Biology 2023

  Quote: ... Oxaliplatin and leucovorin (MedChemExpress) were dissolved in PBS to yield a final concentration of 0.3 Tween-20 required for dispensing with the D300e Dispenser ...
• Development and characterization of new patient-derived xenograft (PDX) models of osteosarcoma with distinct metastatic capacities

  Courtney R. Schott, et al., bioRxiv - Cancer Biology 2023

  Quote: ... Dinaciclib powder (MedChemExpress) was dissolved in DMSO to 50 mg/mL for stock solution ...
• Dual orexin/hypocretin receptor antagonism attenuates attentional impairments in an NMDA receptor hypofunction model of schizophrenia

  Eden B. Maness, et al., bioRxiv - Animal Behavior and Cognition 2023

  Quote: ... Stock solutions of 0.1 mM and 1 mM of filorexant (MedChemExpress) in dimethyl sulfoxide (DMSO ...
• BCR-induced protein dynamics and the emerging role of SUMOylation revealed by proximity proteomics

  Luqman O. Awoniyi, et al., bioRxiv - Immunology 2023

  Quote: ... A20 D1.3 cells were suspended in Imaging Buffer and pretreated with the SUMOylation inhibitor TAK981 (MedChemExpress, HY-111789) at 25 μM final concentration or DMSO as a control in the incubator (5% CO2 ...
• A paradox promoted by microglia cannibalism shortens the lifespan of developmental microglia

  Hannah Gordon, Zachary T. Schafer, Cody J. Smith, bioRxiv - Developmental Biology 2023

  Quote: ... Necrostatin-1 (Nec-1; MedChemExpress LLC, HY-15760)18 ...
• Correcting dilated cardiomyopathy with fibroblast-targeted p38 deficiency

  Ross C. Bretherton, et al., bioRxiv - Cell Biology 2023

  Quote: ... or ilomastat (10μM, MedChemExpress) were added where indicated ...
• Combined KRAS^G12C and SOS1 inhibition enhances and extends the anti-tumor response in KRAS^G12C-driven cancers by addressing intrinsic and acquired resistance

  Venu Thatikonda, et al., bioRxiv - Cancer Biology 2023

  Quote: ... Adagrasib was purchased from MedChemExpress and cetuximab was purchased from MD Anderson Cancer Center pharmacy and BI-3406 was synthesized at Boehringer-Ingelheim ...
• Constitutively synergistic multiagent drug formulations targeting MERTK, FLT3, and BCL-2 for treatment of AML

  James M Kelvin, et al., bioRxiv - Bioengineering 2023

  Quote: ... venetoclax (MedChemExpress; LC Laboratories, Woburn, MA), gossypol (AT-101 ...
• Mechanoaccumulation of non-muscle myosin IIB during mitosis requires its translocation activity

  Chao Wang, et al., bioRxiv - Cell Biology 2023

  Quote: ... 0.5 mg/ml Hydrocortisone (MedChemExpress), 100 ng/ml Cholera toxin (Sigma) ...
• The NLRP3 inflammasome selectively drives IL-1β secretion by Pseudomonas aeruginosa infected neutrophils and regulates bacterial killing in vivo

  Martin S. Minns, et al., bioRxiv - Microbiology 2023

  Quote: ... with 2 μM Birinapant Smac mimetic (MedChemExpress) or 2.5 ng/mL cycloheximide (final concentrations ...
• Functional diversity of the TP53 mutome revealed by saturating CRISPR mutagenesis

  Julianne Funk, et al., bioRxiv - Cancer Biology 2023

  Quote: ... 750 nM AMG 232 (MedChemExpress, HY-12296) or the respective volume of DMSO (Carl Roth GmbH ...
• Propionate reinforces epithelial identity and reduces aggressiveness of non-small cell lung carcinoma via chromatin remodelling

  Vignesh Ramesh, et al., bioRxiv - Cancer Biology 2023

  Quote: ... and GSK343 (MedChemExpress, HY-13500). Sodium butyrate (303410 ...
• Functional diversity of the TP53 mutome revealed by saturating CRISPR mutagenesis

  Julianne Funk, et al., bioRxiv - Cancer Biology 2023

  Quote: ... 75 nM RG7388 (MedChemExpress, HY-15676), 10 µM RO-5963 (Calbiochem ...
• Propionate reinforces epithelial identity and reduces aggressiveness of non-small cell lung carcinoma via chromatin remodelling

  Vignesh Ramesh, et al., bioRxiv - Cancer Biology 2023

  Quote: ... GSK126 (MedChemExpress, HY-13470), and GSK343 (MedChemExpress ...
• Propionate reinforces epithelial identity and reduces aggressiveness of non-small cell lung carcinoma via chromatin remodelling

  Vignesh Ramesh, et al., bioRxiv - Cancer Biology 2023

  Quote: ... A-485 (MedChemExpress, HY-107455), AZD3965 (MedChemExpress ...
• Propionate reinforces epithelial identity and reduces aggressiveness of non-small cell lung carcinoma via chromatin remodelling

  Vignesh Ramesh, et al., bioRxiv - Cancer Biology 2023

  Quote: ... AZD3965 (MedChemExpress, HY-12750), Syrosingopine (Sigma ...
• Propionate reinforces epithelial identity and reduces aggressiveness of non-small cell lung carcinoma via chromatin remodelling

  Vignesh Ramesh, et al., bioRxiv - Cancer Biology 2023

  Quote: ... mocetinostat (MedChemExpress, HY-12164), MI192 (Sigma ...
• Regulated Induced Proximity Targeting Chimeras (RIPTACs): a Novel Heterobifunctional Small Molecule Therapeutic Strategy for Killing Cancer Cells Selectively

  Kanak Raina, et al., bioRxiv - Cancer Biology 2023

  Quote: ... Dinaciclib (HY-10492) were purchased from MedChemExpress.
• ERBB4-mediated signaling is a mediator of resistance to BTK and PI3K inhibitors in B cell lymphoid neoplasms

  Alberto J. Arribas, et al., bioRxiv - Cancer Biology 2023

  Quote: ... Pirtobrutinib was purchased from MedChemExpress. Loncastuximab tesirine was kindly provided by ADC Therapeutics (Epalinges ...
• Cooperative NF-κB and Notch1 signaling promotes macrophage-mediated MenaINV expression in breast cancer

  Camille L. Duran, et al., bioRxiv - Cancer Biology 2023

  Quote: ... DHMEQ (MedChemExpress, cat# HY-14645) was reconstituted in DMSO ...
• Oncogene-like addiction to aneuploidy in human cancers

  Vishruth Girish, et al., bioRxiv - Cancer Biology 2023

  Quote: A 72-hour drug assay was performed to assess cellular sensitivity to the nucleotide analogs RX-3117 (MedChemExpress; cat. no. HY-15228) and 3-deazauridine (Cayman Chemical ...
• RNA sequencing identifies lung cancer lineage and facilitates drug repositioning

  Longjin Zeng, et al., bioRxiv - Cancer Biology 2023

  Quote: ... the H1944 cell line was treated with Verteporfin (HY-B0146, MedChemExpress) for 96 hours ...
• RNA sequencing identifies lung cancer lineage and facilitates drug repositioning

  Longjin Zeng, et al., bioRxiv - Cancer Biology 2023

  Quote: ... BEAS-2B and H1944 cell lines were co-cultured with Dinaciclib (HY-10492, MedChemExpress) for 48 and 72 hours ...
• RNA sequencing identifies lung cancer lineage and facilitates drug repositioning

  Longjin Zeng, et al., bioRxiv - Cancer Biology 2023

  Quote: ... treatment of the H1944 cell line were with Alvocidib (HY-10005, MedChemExpress) for 72 hours.
• Homocysteine accelerates hepatocyte autophagy by upregulation of TFEB via DNMT3b-mediated DNA hypomethylation

  Anning Yang, et al., bioRxiv - Cell Biology 2023

  Quote: ... and Nanaomycin A (NA) were purchased from MedChemExpress (Monmouth ...
• MIIP downregulation promotes colorectal cancer progression via inducing adjacent adipocytes browning

  Qinhao Wang, et al., bioRxiv - Cancer Biology 2023

  Quote: ... was purchased from MedChemExpress (Monmouth Junction, NJ). PNGase F (P0704S ...
• A multidimensional atlas of human glioblastoma organoids reveals highly coordinated molecular networks and effective drugs

  Changwen Wang, et al., bioRxiv - Cancer Biology 2023

  Quote: ... and one library containing drugs targeting the possible targets identified in omics analysis (58 drugs from MedchemExpress, New Jersey, USA). A list of drug information can be found in Supplementary Table 5.
• Targeting the cell and non-cell autonomous regulation of 47S synthesis by GCN2 in colon cancer

  Marie Piecyk, et al., bioRxiv - Cancer Biology 2023

  Quote: ... The GCN2iB was purchased from MedChemExpress (Monmouth Junction, NJ) and also used at final concentration of 5 µM ...
• Bidirectional multiciliated cell extrusion is controlled by Notch driven basal extrusion and Piezo 1 driven apical extrusion

  Rosa Ventrella, et al., bioRxiv - Cell Biology 2023

  Quote: ... whereas GsMTX (MedChemExpress, #HY-P1410) was used to inhibit Piezo1 channels ...
• rRNA intermediates coordinate the multilayered nucleolar phase transition in C. elegans

  Demin Xu, et al., bioRxiv - Cell Biology 2023

  Quote: Actinomycin D (MedChemExpress no. HY-17559, CAS:50-76–0) was prepared at 20 mg/ml in DMSO as a stock solution ...
• Genome-wide CRISPR screen reveals genetic modifiers of Ca²⁺-mediated cell death

  Oscar E. Reyes Gaido, et al., bioRxiv - Cell Biology 2023

  Quote: ... cells were pretreated with YM-58483 (MedChemExpress) or vehicle for 2 hours prior to ionomycin challenge.
• Age-dependent loss of cohesion protection in human oocytes

  Bettina P Mihalas, et al., bioRxiv - Cell Biology 2023

  Quote: ... 10004412)27 or 10μM BAY-320 (MedChemExpress, HY-104000)46,52 ...
• Rapid PTEFb-dependent transcriptional reorganization underpins the glioma adaptive response to radiotherapy

  Faye M. Walker, et al., bioRxiv - Cancer Biology 2023

  Quote: ... TG02 (MedChemExpress), or ionizing radiation as indicated before adding MTS reagent (Promega ...
• Identification of S1PR4 as an immune modulator for favourable prognosis in HNSCC through unbiased machine learning

  Chenshen Huang, Fengshuo Zhu, Ning Wang, Qi Huang, bioRxiv - Cancer Biology 2023

  Quote: ... S1PR4-inhibitor (CYM50358, MedChemExpress, 100 nM) and S1PR4-agonist (CYM50308 ...
• Identification of S1PR4 as an immune modulator for favourable prognosis in HNSCC through unbiased machine learning

  Chenshen Huang, Fengshuo Zhu, Ning Wang, Qi Huang, bioRxiv - Cancer Biology 2023

  Quote: ... S1PR4-inhibitor (CYM50358, MedChemExpress, 100 nM) and S1PR4-agonist (CYM50308 ...
• Identification of S1PR4 as an immune modulator for favourable prognosis in HNSCC through unbiased machine learning

  Chenshen Huang, Fengshuo Zhu, Ning Wang, Qi Huang, bioRxiv - Cancer Biology 2023

  Quote: ... and S1PR4-agonist (CYM50308, MedChemExpress, 100 nM) for 2 h ...
• Identification of S1PR4 as an immune modulator for favourable prognosis in HNSCC through unbiased machine learning

  Chenshen Huang, Fengshuo Zhu, Ning Wang, Qi Huang, bioRxiv - Cancer Biology 2023

  Quote: ... and S1PR4-agonist (CYM50308, MedChemExpress, 100 nM) for 2 h ...
• Multiple cancer types rapidly escape from multiple MAPK inhibitors to generate mutagenesis-prone subpopulations

  Timothy E. Hoffman, et al., bioRxiv - Cancer Biology 2023

  Quote: ... AZD0156 (ATMi, MedChemExpress #HY-100016); Aphidicolin (DNA Pol α/δ inhibitor ...
• Paradoxical activation of oncogenic signaling as a cancer treatment strategy

  Matheus Henrique Dias, et al., bioRxiv - Cancer Biology 2023

  Quote: ... and gemcitabine #HY-17026 were purchased from MedChemExpress.
• A CRISPRi/a screening platform to study cellular nutrient transport in diverse microenvironments

  Christopher Chidley, et al., bioRxiv - Cancer Biology 2023

  Quote: ... Erastin (MedChemExpress HY–15763), Ferrostatin-1 (Selleckchem S7243 ...