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7651 - 7700 of 10000+ citations for 5 Pyrimidinecarbonitrile 2 4 diamino 6 methyl since 2019

• Massively parallel characterization of CYP2C9 variant enzyme activity and abundance

  Clara J. Amorosi, et al., bioRxiv - Genomics 2021

  Quote: ... 2 mM CuSO4 (Sigma C8027), 4 mM THPTA (Sigma 762342) ...
• ZFP462 targets heterochromatin to transposon-derived enhancers restricting transcription factor binding and expression of lineage-specifying genes

  Ramesh Yelagandula, et al., bioRxiv - Genetics 2021

  Quote: ... 0.1 mM 2-mercaptoethanol (Sigma), 50 mg ml-1 penicillin ...
• Aberrant enteric neuromuscular system and dysbiosis in amyotrophic lateral sclerosis

  Yongguo Zhang, et al., bioRxiv - Physiology 2021

  Quote: ... 2% SDS (Sigma-Aldrich, L3771), 0.1% bromophenol blue (IBI Scientific ...
• Multiplexed VaxArray Immunoassay for Rapid Antigen Quantification in Measles and Rubella Vaccine Manufacturing

  Jacob H. Gillis, et al., bioRxiv - Immunology 2021

  Quote: ... and 2% gelatin (G1393, Sigma) were prepared (w/v ...
• A novel small molecule that induces cytotoxicity in lung cancer cells inhibits disulfide reductases GSR and TXNRD1

  Fraser D. Johnson, et al., bioRxiv - Cancer Biology 2021

  Quote: ... 2-AAPA (Sigma, A4111-5MG), C1-27 (MedChemExpress ...
• Kinesin-6 Klp9 orchestrates spindle elongation by regulating microtubule sliding and growth

  Lara K. Krüger, et al., bioRxiv - Cell Biology 2021

  Quote: ... in 2% Hellmanex (Sigma Aldrich) and using a plasma-cleaner ...
• Super-dosed butyrate induces a revisable metabolic paralysis through transient mitochondrial reprogramming in the gut-brain axis

  Yanhong Xu, et al., bioRxiv - Pharmacology and Toxicology 2020

  Quote: ... FCCP (2 μM, C2920, Sigma), and Antimycin A (AA ...
• Cooperative regulation of adherens junction elongation through Epidermal Growth Factor Receptor (EGFR) activation

  Chaoyu Fu, et al., bioRxiv - Biophysics 2021

  Quote: ... Nocodazole (2-40μM, Sigma-Aldrich).
• BRAWNIN: A sORF-encoded Peptide Essential for Vertebrate Mitochondrial Complex III Assembly

  Shan Zhang, et al., bioRxiv - Cell Biology 2020

  Quote: ... 2 μM of oligomycin (Sigma), 1 μM of FCCP (Sigma) ...
• EM-seq: Detection of DNA Methylation at Single Base Resolution from Picograms of DNA

  Romualdas Vaisvila, et al., bioRxiv - Genomics 2020

  Quote: ... 50 μM 2-mercaptoethanol (Sigma), and 1× LIF (Millipore) ...
• Similar neuronal imprint and absence of cross-seeded partner fibrils in α-synuclein aggregates from MSA and Parkinson’s disease brains

  Florent Laferrière, et al., bioRxiv - Neuroscience 2021

  Quote: ... 2 U.μl-1 Benzonase (Novagen) and 4 mM MgCl2 ...
• Laminin alpha 5 is Necessary for Mammary Epithelial Growth and Function by Maintaining Luminal Epithelial Cell Identity

  Johanna I Englund, et al., bioRxiv - Cell Biology 2019

  Quote: ... and 2 mM glutamine (Sigma).
• Laminin alpha 5 is Necessary for Mammary Epithelial Growth and Function by Maintaining Luminal Epithelial Cell Identity

  Johanna I Englund, et al., bioRxiv - Cell Biology 2019

  Quote: ... and 2 mM glutamine (Sigma). Transfections of transfer vector (pLentiCRISPRv2 SCRA ...
• ENGINEERING, DECODING AND SYSTEMS-LEVEL CHARACTERIZATION OF CHIMPANZEE CYTOMEGALOVIRUS

  Quang Vinh Phan, et al., bioRxiv - Microbiology 2021

  Quote: ... 2 µl Benzonase (Merck-Millipore) and sonicated for 45 min (intervals ...
• Serine ADP-ribosylation marks nucleosomes for ALC1-dependent chromatin remodeling

  Jugal Mohapatra, et al., bioRxiv - Biochemistry 2021

  Quote: ... 2 mM NAD+ (Sigma-Aldrich), and 1 μM stimulating DNA (or 2 μM for H2B peptides ...
• Serine ADP-ribosylation marks nucleosomes for ALC1-dependent chromatin remodeling

  Jugal Mohapatra, et al., bioRxiv - Biochemistry 2021

  Quote: ... 2 mM ATP (Sigma-Aldrich), and final concentrations of 4 nM ALC1 or 10 nM CHD4 and 20 nM of the desired nucleosome substrate ...
• Cas9-Assisted Biological Containment of a Genetically Engineered Human Commensal Bacterium and Genetic Elements

  Naoki Hayashi, et al., bioRxiv - Synthetic Biology 2021

  Quote: ... 2 g/L glucose (Sigma), 80 mM potassium phosphate buffer (pH 7.3) ...
• Development and validation of inducible protein degradation and quantitative phosphoproteomics to identify kinase-substrate relationships

  Rufus Hards, et al., bioRxiv - Systems Biology 2021

  Quote: ... sodium molybdate (2 mM; Sigma), sodium orthovanadate (2 mM ...
• Development and validation of inducible protein degradation and quantitative phosphoproteomics to identify kinase-substrate relationships

  Rufus Hards, et al., bioRxiv - Systems Biology 2021

  Quote: ... sodium orthovanadate (2 mM; Sigma) and EDTA-free Mini-Complete protease inhibitors (1 tablet per 10mL ...
• Refining the Identity and Role of Kv4 Channels in Mouse Substantia Nigra Dopaminergic Neurons

  Alexis Haddjeri-Hopkins, et al., bioRxiv - Neuroscience 2021

  Quote: Kynurenate (2 mM, Sigma-Aldrich) and picrotoxin (100 μM ...
• Resistance to miltefosine results from amplification of the RTA3 floppase or inactivation of flippases in Candida parapsilosis

  Sean A. Bergin, et al., bioRxiv - Genomics 2021

  Quote: ... 2% Bacto Peptone (211677, Sigma), 2% Bacto Agar (214010 ...
• Resistance to miltefosine results from amplification of the RTA3 floppase or inactivation of flippases in Candida parapsilosis

  Sean A. Bergin, et al., bioRxiv - Genomics 2021

  Quote: ... 2% D-(+)-Glucose (G8270, Sigma)) ...
• Resistance to miltefosine results from amplification of the RTA3 floppase or inactivation of flippases in Candida parapsilosis

  Sean A. Bergin, et al., bioRxiv - Genomics 2021

  Quote: ... 2% Bacto Agar (214010, Sigma), 2% D-(+)-Glucose (G8270 ...
• Encoding of odors by mammalian olfactory receptors

  Aashutosh Vihani, et al., bioRxiv - Neuroscience 2021

  Quote: ... 1% 2-hexanone (Sigma 103004), 1% 2-phenylethanol (Sigma 77861) ...
• Encoding of odors by mammalian olfactory receptors

  Aashutosh Vihani, et al., bioRxiv - Neuroscience 2021

  Quote: ... 10% (-)-2-octanol (Sigma 147990), 1% 2-hexanone (Sigma 103004) ...
• Encoding of odors by mammalian olfactory receptors

  Aashutosh Vihani, et al., bioRxiv - Neuroscience 2021

  Quote: ... 1% 2-phenylethanol (Sigma 77861), 1% 3-methyl-1-butanethiol (Sigma W385808) ...
• Encoding of odors by mammalian olfactory receptors

  Aashutosh Vihani, et al., bioRxiv - Neuroscience 2021

  Quote: ... 1% 2-heptanone (Sigma 53768315), 1% linalool (Sigma L2602) ...
• Encoding of odors by mammalian olfactory receptors

  Aashutosh Vihani, et al., bioRxiv - Neuroscience 2021

  Quote: ... 10% (+)-2-octanol (Sigma O4504), 10% (-)-2-octanol (Sigma 147990) ...
• The H3K36me2 writer-reader dependency in H3K27M-DIPG

  Jia-Ray Yu, et al., bioRxiv - Cancer Biology 2021

  Quote: ... 2 mM L-glutamine (Sigma), and 1% penicillin/streptomycin solution (Sigma).
• SDF-1/CXCR4 inhibition prevents paradoxical generation of cisplatin-induced pro-metastatic niches

  Giulia Bertolini, et al., bioRxiv - Cancer Biology 2020

  Quote: ... 2×104 PKH-26 (Sigma) stained H460 cells were plated onto the HUVEC endothelial cells layer and after 48h migrated H460 cells were fixed with PFA 4% and counted under a fluorescence microscope.
• Genetic engineering of hoxb8 immortalized hematopoietic progenitors: a potent tool to study macrophage tissue migration

  Solene Accarias, et al., bioRxiv - Cell Biology 2019

  Quote: ... 2 µM Pepstatine A (Sigma), 5 µM GM-6001 (VWR ...
• Fetal-like reversion in the regenerating intestine is regulated by mesenchymal Asporin

  Sharif Iqbal, et al., bioRxiv - Developmental Biology 2021

  Quote: ... 2 mM L-glutamine (Sigma), and 75 ug/ml of Zeocin (Sigma) ...
• Salt Inducible Kinase activation and IRE1-dependent intracellular ATP depletion to form Sec bodies in Drosophila cells

  Chujun Zhang, et al., bioRxiv - Cell Biology 2021

  Quote: ... 10mM 2-deoxyglucose (Sigma-Aldrich) and 10mM NaN3 (Fisher scientific ...
• Atg39 selectively captures inner nuclear membrane into lumenal vesicles for delivery to the autophagosome

  Sunandini Chandra, et al., bioRxiv - Cell Biology 2021

  Quote: ... 2% D-glucose (D; Sigma). To maintain selection of plasmids ...
• Thermogenic genes are blunted whereas brown adipose tissue identity is preserved in human obesity

  Naja Z. Jespersen, et al., bioRxiv - Cell Biology 2020

  Quote: ... 2 nM T3 (Sigma‐Aldrich) and 10 μg/ml transferrin (Sigma‐Aldrich) ...
• Cargo receptor-assisted endoplasmic reticulum export of pathogenic α1-antitrypsin polymers

  Adriana Ordonez, et al., bioRxiv - Cell Biology 2020

  Quote: ... 2 mM L-glutamine (Sigma), 200 μg/mL G418 and 500 μg/mL of Hygromycin B (Invitrogen) ...
• A Mycobacterium tuberculosis effector protein attacks host innate immunity by acting as an unusual ubiquitinating enzyme

  Jing Wang, et al., bioRxiv - Microbiology 2020

  Quote: ... 2 mM ATP (A6559, Sigma) or ATP analogs including APCPP (M6517 ...
• The Food Additive Xanthan Gum Drives Adaptation of the Human Gut Microbiota

  Matthew P. Ostrowski, et al., bioRxiv - Microbiology 2021

  Quote: ... 2 mg biotin (Sigma, B4501), 5 mg nicotinic acid (Sigma ...
• Robust T cell activation requires an eIF3-driven burst in T cell receptor translation

  Dasmanthie De Silva, et al., bioRxiv - Molecular Biology 2021

  Quote: ... 50 μM 2-mercaptoethanol (Sigma), and 10 μM N-acetyl-cystine (Sigma ...
• In vitro discovery and optimization of a human monoclonal antibody that neutralizes neurotoxicity and lethality of cobra snake venom

  Line Ledsgaard, et al., bioRxiv - Molecular Biology 2021

  Quote: ... 2 U acetylcholinesterase (Sigma-Aldrich) was added to ensure complete ACh removal ...
• Osmotic stress-induced, rapid clustering of IGF2BP proteins nucleates stress granule assembly

  Wei-jie Zeng, et al., bioRxiv - Cell Biology 2019

  Quote: ... 200mM 2-DG (D8375, Sigma) and 100µM CCCP (C2759 ...
• Identification of determinants of differential chromatin accessibility through a massively parallel genome-integrated reporter assay

  Jennifer Hammelman, et al., bioRxiv - Genomics 2020

  Quote: ... 0.55mM 2 β-mercaptoethanol (Sigma), 1X ESGRO LIF (Millipore) ...
• Inflammatory Cytokines Regulate T-Cell Development from Blood Progenitor Cells in a Stage and Dose-Specifc Manner

  John M. Edgar, Peter W. Zandstra, bioRxiv - Immunology 2021

  Quote: ... 24 μM 2-mercaptoethanol (Sigma), and 1% penicillin-streptomycin (Invitrogen) ...
• Berberine and obatoclax inhibit SARS-CoV-2 replication in primary human nasal epithelial cells in vitro

  Finny S. Varghese, et al., bioRxiv - Microbiology 2020

  Quote: ... containing 2% FCS (Sigma-Aldrich), 20 mM HEPES buffer (Gibco) ...
• Berberine and obatoclax inhibit SARS-CoV-2 replication in primary human nasal epithelial cells in vitro

  Finny S. Varghese, et al., bioRxiv - Microbiology 2020

  Quote: ... containing 2% FCS (Sigma-Aldrich), 100 μg/ml gentamycin (Gibco ...
• Comprehensive label-free characterization of extracellular vesicles and their surface proteins

  E. Priglinger, et al., bioRxiv - Molecular Biology 2020

  Quote: ... 2 ng rhCD73 (Sigma N1665) was used as positive control and AMP-CP (Sigma M8386 ...
• Hemoglobin drives inflammation and initiates antigen spread and nephritis in lupus

  Hritika Sharma, Anjali Bose, Uma Kumar, Rahul Pal, bioRxiv - Immunology 2020

  Quote: ... monensin (2 µM; Sigma Aldrich) was added 3 h after the addition of PMA and ionomycin ...
• A new concept on anti-SARS-CoV-2 vaccines: strong CD8⁺ T-cell immune response in both spleen and lung induced in mice by endogenously engineered extracellular vesicles

  Flavia Ferrantelli, et al., bioRxiv - Immunology 2020

  Quote: ... 50 μM 2-mercaptoethanol (Sigma) for 16 h in the presence of 5 μg/mL of the following CD8-specific peptides ...
• A new concept on anti-SARS-CoV-2 vaccines: strong CD8⁺ T-cell immune response in both spleen and lung induced in mice by endogenously engineered extracellular vesicles

  Flavia Ferrantelli, et al., bioRxiv - Immunology 2020

  Quote: ... 50 μM 2-mercaptoethanol (Sigma), and 1 μg/mL Brefeldin A (BD Biosciences) ...
• A new concept on anti-SARS-CoV-2 vaccines: strong CD8⁺ T-cell immune response in both spleen and lung induced in mice by endogenously engineered extracellular vesicles

  Flavia Ferrantelli, et al., bioRxiv - Immunology 2020

  Quote: ... 50 μM 2-mercaptoethanol (Sigma). Splenocytes were extracted by incising the spleen with sterile scissors and pressing the cells out of the spleen sac with the plunger seal of a 1 mL syringe ...