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351 - 400 of 856 citations for 1 2 Chloropyridin 3 yl 3 3 dimethylazetidin 2 one since 2020

• Concerted SUMO-targeted ubiquitin ligase activities of TOPORS and RNF4 are essential for stress management and cell proliferation

  Julio C.Y. Liu, et al., bioRxiv - Molecular Biology 2023

  Quote: ... and USP7 (1:1,000, Bethyl (A300-033A, RRID:AB_203276)).
• UPF1 ATPase autoinhibition and activation modulate RNA binding kinetics and NMD efficiency

  Joseph H. Chapman, et al., bioRxiv - Molecular Biology 2023

  Quote: ... 1:1000 rabbit anti-RENT2 (Bethyl A303-929A) was used for UPF2 detection ...
• HELZ promotes R loop resolution to facilitate DNA double-strand break repair by homologous recombination

  Ramona Haji-Seyed-Javadi, et al., bioRxiv - Molecular Biology 2023

  Quote: ... 53BP1 (Bethyl # A300-273A; 1:1000 for IF); RPA32 (Santa Cruz Tech # sc-14692 ...
• UPF1 ATPase autoinhibition and activation modulate RNA binding kinetics and NMD efficiency

  Joseph H. Chapman, et al., bioRxiv - Molecular Biology 2023

  Quote: ... 1:5000 goat anti-Rent1 (Bethyl A300-038A) was used for UPF1 detection ...
• Identification of the KIF18A alpha-4 helix as a therapeutic target for chromosomally unstable tumor cells

  Katherine Schutt, et al., bioRxiv - Cancer Biology 2023

  Quote: ... rabbit anti-KIF18A 1:100 (Bethyl, A301-080A), and mouse anti-γ-tubulin 1:500 (Sigma Aldrich ...
• Bridge-like lipid transfer protein family member 2 suppresses ciliogenesis

  Jan Parolek, Christopher G. Burd, bioRxiv - Cell Biology 2023

  Quote: ... and anti-WDR44 (1:500; A301-440A, Bethyl). Fluorescent secondary antibodies were purchased from Invitrogen ...
• Harnessing DNA replication stress to target RBM10 deficiency in lung adenocarcinoma

  Feras E. Machour, et al., bioRxiv - Molecular Biology 2023

  Quote: ... pRPA32-S33 (Bethyl cat.no. A300-246A, 1:500), γH2AX (Millipore cat.no ...
• Identification of the KIF18A alpha-4 helix as a therapeutic target for chromosomally unstable tumor cells

  Katherine Schutt, et al., bioRxiv - Cancer Biology 2023

  Quote: ... rabbit anti-KIF18A 1:100 (Bethyl, A301-080A), human anti-centromere antibody (ACA ...
• Identification of the KIF18A alpha-4 helix as a therapeutic target for chromosomally unstable tumor cells

  Katherine Schutt, et al., bioRxiv - Cancer Biology 2023

  Quote: ... rabbit anti-KIF18A 1:100 (Bethyl, A301-080A), rat anti-α-tubulin 1:500 (Sigma Aldrich ...
• Harnessing DNA replication stress to target RBM10 deficiency in lung adenocarcinoma

  Feras E. Machour, et al., bioRxiv - Molecular Biology 2023

  Quote: ... pRPA32-S33 (Bethyl cat.no. A300-246A, 1:1,000), RPA32 (Abcam cat.no ...
• Cleavage of 14-3-3ε by the enteroviral 3C protease dampens RIG-I mediated antiviral signaling

  Daniel D.T. Andrews, et al., bioRxiv - Microbiology 2022

  Quote: ... 1:2000 myc tag antibody (Bethyl A190-105A); 1:2000 FLAG M2 (Millipore F1804) ...
• Segregation of pathways leading to pexophagy

  Francesco G. Barone, et al., bioRxiv - Cell Biology 2022

  Quote: ... anti-Cullin2 (Bethyl, A302-476A, 1:2000 WB), anti-HIF1α (NB100-134 ...
• α-syn overexpression, NRF2 suppression, and enhanced ferroptosis create a vicious cycle of neuronal loss in Parkinson’s disease

  A Anandhan, et al., bioRxiv - Neuroscience 2022

  Quote: ... Anti-NCOA4 (ARA70, 1:2000) was from Bethyl Laboratories (Montgomery ...
• A Photoactivated Protein Degrader for Optical Control of Synaptic Function

  T. Ko, et al., bioRxiv - Neuroscience 2023

  Quote: ... and VINC (1:1000, Bethyl Laboratories A302-535A) primary antibodies overnight at 4 °C ...
• Human papillomavirus 16 E2 interaction with TopBP1 is required for E2 and viral genome stability during the viral life cycle

  Apurva T. Prabhakar, et al., bioRxiv - Cancer Biology 2023

  Quote: ... TopBP1 1:1,000 (Bethyl, catalog no. A300-111A), GAPDH 1:10,000 (Santa Cruz ...
• Notch1 cortical signaling regulates epithelial architecture and cell-cell adhesion

  Matthew J. White, et al., bioRxiv - Cell Biology 2023

  Quote: ... FAM83H antibody (1:1000 WB) was from Bethyl Laboratories ...
• Histone demethylase KDM2A is a selective vulnerability of cancers relying on alternative telomere maintenance

  Fei Li, et al., bioRxiv - Cancer Biology 2023

  Quote: ... BLM (1:250, Cat# A300-110A; Bethyl Laboratories), FLAG (1:200 ...
• Arginine shortage induces replication stress and confers genotoxic resistance by inhibiting histone H4 translation and promoting PCNA polyubiquitination

  Yi-Chang Wang, et al., bioRxiv - Cancer Biology 2023

  Quote: ... anti-γH2AX (1:3000; Cat# A300-081, Bethyl), anti-histone H3 (1:20000 ...
• CCDC15 localizes to the centriole inner scaffold and regulates centriole integrity and ciliogenesis

  Melis D. Arslanhan, et al., bioRxiv - Cell Biology 2023

  Quote: ... rabbit anti CEP152 (1:1000, Bethyl, A302-479), mouse anti α-tubulin (DM1A ...
• The RNA helicase DDX1 associates with the nuclear RNA exosome and modulates R-loops

  Julia L. de Amorim, et al., bioRxiv - Biochemistry 2023

  Quote: ... EXOSC9 (rabbit polyclonal; Bethyl A303-888A; 1:2000), EXOSC3 (rabbit polyclonal ...
• Pancreatic loss of Mig6 alters murine endocrine cell fate and protects functional beta cell mass in an STZ-induced model of diabetes

  Brandon M. Bauer, et al., bioRxiv - Physiology 2023

  Quote: ... rabbit anti MAFA (Bethyl Laboratories BLR067G, 1:200), and Invitrogen Alexa Fluor conjugated secondary antibodies produced in goat ...
• Replicative stress in gastroesophageal adenocarcinoma is associated with chromosomal instability and sensitivity to DNA damage response inhibitors

  Pranshu Sahgal, et al., bioRxiv - Cancer Biology 2023

  Quote: ... rabbit anti-RPA32 (1:1000, Bethyl, A300-244A) and rabbit anti-pRPA32 (1:1000 ...
• Modification of the Neck Linker of KIF18A Alters Microtubule Subpopulation Preference

  Katelyn A. Queen, et al., bioRxiv - Cell Biology 2023

  Quote: ... and rabbit-HURP 1:500 (Bethyl, A300-851A), all for one hour at room temperature with shaking ...
• PRMT1 is a critical dependency in clear cell renal cell carcinoma through its role in post-transcriptional regulation of DNA damage response genes

  Joseph Walton, et al., bioRxiv - Cancer Biology 2023

  Quote: ... BCLAF1 (Thermo/Bethyl Labs, #A300-608A, 1:1000), CAS9 (Abcam ...
• PDZD8-FKBP8 tethering complex at ER-mitochondria contact sites regulates mitochondrial complexity

  Koki Nakamura, et al., bioRxiv - Cell Biology 2024

  Quote: ... anti-VAPA (Bethyl laboratories, A304-366A; 1:1,000), anti-Mfn2 (Abcam ...
• Condensin II activation by M18BP1

  Alessandro Borsellini, et al., bioRxiv - Cell Biology 2024

  Quote: ... CAP-G2 (A300-605A, Bethyl Laboratories, 1:500), CAP- H (NBP1-32573 ...
• U2AF regulates the translation and localization of nuclear-encoded mitochondrial mRNAs

  Gloria R. Garcia, et al., bioRxiv - Molecular Biology 2024

  Quote: ... EIF3J at 1:500 (Bethyl, A301-746A-M), GIGYF2 at 1:500 (Bethyl ...
• TAF1-dependent transcriptional dysregulation underlies multiple sclerosis

  Claudia Rodríguez-López, et al., bioRxiv - Neuroscience 2024

  Quote: ... rabbit anti-SMC1 (1:2000; Bethyl, A300-055A), rabbit anti-vinculin (1:15,000 ...
• Multimodal mechanisms of human centriole engagement and disengagement

  Kei K Ito, et al., bioRxiv - Cell Biology 2024

  Quote: ... Cep192 (Bethyl Laboratories; A302-324A; IF, 1:1,000), CP110 (Proteintech ...
• Availability of an inflammatory macrophage niche drives phenotypic and functional alterations in Kupffer cells

  Han-Ying Huang, et al., bioRxiv - Immunology 2024

  Quote: ... anti-HA Tag (Bethyl, #A190-138A, 1:500), anti-HA Tag (abcam ...
• Microtubule pivoting driven by spindle elongation rescues polar chromosomes to ensure faithful mitosis

  Isabella Koprivec, et al., bioRxiv - Cell Biology 2024

  Quote: ... rabbit anti-Spindly/CCD99 (1:1000, A301_354A, Bethyl), mouse anti-KIF4A (1:100 ...
• Human RNase H2 upregulation counteracts oncogene- and chemotherapy-induced replication stress

  Rosanna J. Wilkins, et al., bioRxiv - Molecular Biology 2024

  Quote: ... rabbit anti-53BP1 (Bethyl A300-272A, 1:3000), mouse anti-phospho-Histone H2AX (Merck JBW301 ...
• Suppression of NRF2-dependent cancer growth by a covalent allosteric molecular glue

  Nilotpal Roy, et al., bioRxiv - Cancer Biology 2024

  Quote: ... SQSTM1 (Bethyl, Cat. # A302-856A-T, 1:1000), TSC22D4 (Bethyl ...
• p53 isoforms have a high aggregation propensity, interact with chaperones and lack binding to p53 interaction partners

  Anamari Brdar, et al., bioRxiv - Biophysics 2024

  Quote: ... anti-HA (goat polyclonal, Bethyl Laboratories, 1:1000), anti-p53 (DO-1 ...
• Break-induced replication drives large-scale genomic amplifications in cancer cells

  Mouadh Benamar, et al., bioRxiv - Cancer Biology 2024

  Quote: ... RIF1 (1:1000, A300-569A-M; Bethyl Laboratories), RNF8 (1:1000 ...
• Break-induced replication drives large-scale genomic amplifications in cancer cells

  Mouadh Benamar, et al., bioRxiv - Cancer Biology 2024

  Quote: ... XLF (1:1000, A300-730A-M; Bethyl Laboratories), NBS1 (1:1000 ...
• Single Nuclei Sequencing Reveals Intratumoral Cellular Heterogeneity and Replication Stress in Adrenocortical Carcinoma

  Liudmila V. Popova, et al., bioRxiv - Cancer Biology 2024

  Quote: ... at 1:500 and rabbit anti-RPA (Bethyl Laboratories ...
• TRF1 and TRF2 form distinct shelterin subcomplexes at telomeres

  Tomáš Janovič, Gloria I. Perez, Jens C. Schmidt, bioRxiv - Cell Biology 2024

  Quote: ... anti-TPP1 (Bethyl #A303-069A, 1:2,000 dilution), anti-POT1 (Proteintech #10581-1-AP ...
• The Unkempt RNA binding protein reveals a local translation program in centriole overduplication

  Abraham Martinez, et al., bioRxiv - Cell Biology 2024

  Quote: ... 1:2500 rabbit α-CEP152 (Bethyl A302- 480A); rabbit 1:2000 α-CEP192 (the generous gift of A ...
• Cell-type-specific splicing of transcription regulators and Ptbp1 by Rbfox1/2/3 in the developing neocortex

  Xiangbin Ruan, et al., bioRxiv - Developmental Biology 2024

  Quote: ... anti-Rbfox2 (Bethyl A300-864A, rabbit, 1:500), anti-Rbfox3/NeuN (Cell Signaling Technology 24307T ...
• The tubule-sheet continuum model links the pattern of nuclear envelope assembly to nuclear envelope integrity

  Sanjana Arun, Gengjing Zhao, bioRxiv - Cell Biology 2024

  Quote: ... rabbit Lap2β (1:200, Bethyl Laboratories, A304-840A), rabbit NUP133 (1:300 ...
• A nuclear receptor facilitates differentiation of human PSCs into more mature hepatocytes

  Haiting Ma, et al., bioRxiv - Developmental Biology 2022

  Quote: ... followed by primary antibodies (1:100 mouse-anti-CYP3A4 antibody Life Technologies MA5-17064, 1:100 goat-anti-hALB antibody, Bethyl Laboratories A80-229A ...
• Centriole and PCM cooperatively recruit CEP192 to spindle poles to promote bipolar spindle assembly

  Takumi Chinen, et al., bioRxiv - Cell Biology 2020

  Quote: The following primary antibodies were used in this study: rabbit polyclonal antibodies against CDK5RAP2 (IHC00063: immunofluorescence [IF] 1:500, Western Blotting [WB] 1:1000; Bethyl Laboratories), Cep192 (A302–324A ...
• Cleavage of 14-3-3ε by the enteroviral 3C protease dampens RIG-I mediated antiviral signaling

  Daniel D.T. Andrews, et al., bioRxiv - Microbiology 2022

  Quote: ... 500 µg-1 mg of cell lysate was then incubated with 1:100 w/w myc tag antibody (Bethyl A190-105A) or anti-FLAG M2 (Millipore F1804 ...
• Reprogramming Adeno-Associated Virus Tropism Via Displayed Peptides Tiling Receptor-Ligands

  Andrew Portell, et al., bioRxiv - Bioengineering 2022

  Quote: ... Wells were 3x washed and 100 µL of HRP-labeled goat anti-mouse IgG1 (Bethyl; diluted 1:100,000 in 1% BSA) was added to each well ...
• PML and PML-like exonucleases restrict retrotransposons in jawed vertebrates

  Sabateeshan Mathavarajah, et al., bioRxiv - Molecular Biology 2022

  Quote: ... PML (two antibodies used; sheep anti-PML, Diagnostics Scotland, PML2A, 1:500; rabbit anti-PML, Bethyl Laboratories, A301-167A, 1:1000), SUMO (two antibodies used ...
• Small-molecule Activation of TFEB Alleviates Niemann-Pick Disease Type C via Promoting Lysosomal Exocytosis and Biogenesis

  Kaili Du, et al., bioRxiv - Molecular Biology 2024

  Quote: ... Western blot analysis was performed using primary antibodies against TFEB (1:500, Cell Signaling Technology, 4240 for cells, 1:1000, Bethyl Laboratories ...
• Single-molecule live imaging of subunit interactions and exchange within cellular regulatory complexes

  Thomas G.W. Graham, et al., bioRxiv - Molecular Biology 2024

  Quote: ... The membrane in Figure S2H was probed for 1 h with 1:1000 rabbit anti-LARP7 antibody (Fortis/Bethyl #A303-723A) in 5% BSA/TBST ...
• A Red Fluorescent Lifeact Marker to Study Actin Morphology in Podocytes

  Eva Wiesner, et al., bioRxiv - Cell Biology 2024

  Quote: ... a 96-well plate was covered with an α-mouse albumin antibody (1:10.000) for 1 h at RT (A90-134A, Bethyl Laboratories). The plate was washed 5 times and incubated with a blocking solution for 30 min followed by further 5 washing steps ...
• Human peroxiredoxin 6 is essential for malaria parasites and provides a host-based drug target

  Matthias Paulus Wagner, et al., bioRxiv - Cell Biology 2022

  Quote: ... falciparum nucleosome assembly protein L (α-PfNAPL 1:500) (Singh et al., 2010) and goat antisera against human hemoglobin (α-hHb HRP 1:5000, Bethyl) in PBS with 2.5% skimmed milk and 0.05% Tween 20 for 2h at RT ...