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51 - 100 of 855 citations for 1 6 Chloropyridazin 3 yl piperidine 4 carboxamide since 2020

• The Dystonia Gene THAP1 Controls DNA Double Strand Break Repair Choice

  Kenta Shinoda, et al., bioRxiv - Molecular Biology 2020

  Quote: ... phospho-KAP-1 (S824) (1:500, Bethyl, A300-767A), NeuN (1:500 ...
• Hierarchical TAF1-dependent co-translational assembly of the basal transcription factor TFIID

  Andrea Bernardini, et al., bioRxiv - Molecular Biology 2023

  Quote: ... TAF10 (3 μg/mL, mouse mAb, 6TA 2B11), TBP (2 μg/mL, mouse mAb, 3TF1 3G3) or SUPT7L (rabbit pAb, Bethyl, A302-803A). A secondary-only control sample was incubated with BPS devoid of primary antibody ...
• MeCP2 Interacts with the Super Elongation Complex to Regulate Transcription

  Jun Young Sonn, et al., bioRxiv - Molecular Biology 2024

  Quote: ... Blocking Buffer (Li-Cor; 927-60010) and then incubated with the following primary antibodies overnight at 4°C: AFF4 (Bethyl; A302-538A at 1:1,000 and Proteintech ...
• SARS-CoV-2 predation of Golgi-bound PI4P primes the massive activation of the DNA Damage Response kinase ATM in the cytoplasm

  Antoine Rebendenne, et al., bioRxiv - Microbiology 2024

  Quote: anti-KAP-1 (BETA300-274A, Bethyl, WB at 1/2,000),
• SARS-CoV-2 predation of Golgi-bound PI4P primes the massive activation of the DNA Damage Response kinase ATM in the cytoplasm

  Antoine Rebendenne, et al., bioRxiv - Microbiology 2024

  Quote: antitotal KAP-1 (BETA300-274A, Bethyl, WB at 1/2,000)
• ARID2 deficiency promotes tumor progression and is associated with higher sensitivity to PARP inhibition in lung cancer

  Thaidy Moreno, et al., bioRxiv - Cancer Biology 2020

  Quote: ... Finally there were subjected to immunofluorescence staining with ARID2 antibody (E-3, sc-166117 Santa Cruz, CA, USA or A302-230A, Bethyl Laboratories, USA), anti-phospho-Histone H2A.X Ser139 (γH2AX ...
• Nephronophthisis-associated FBW7 mediates cyst-dependent decline of renal function in ADPKD

  Maulin Mukeshchandra Patel, et al., bioRxiv - Genetics 2024

  Quote: ... The antibodies used were FBW7 (1:1000 in a 1:1 ratio, Bethyl A301-720A, and A301-721A) and GAPDH (1:4,000 ...
• USP37 prevents premature disassembly of stressed replisomes by TRAIP

  Olga V. Kochenova, et al., bioRxiv - Molecular Biology 2024

  Quote: ... MCM6 (1:5,000; Ref.7); MCM7 (1:12,000) and RPA (1:7,000; Ref.55; MCM4 (1:2,000; (Bethyl A300-193A)) ...
• Centriole and PCM cooperatively recruit CEP192 to spindle poles to promote bipolar spindle assembly

  Takumi Chinen, et al., bioRxiv - Cell Biology 2020

  Quote: ... Cep192 (A302–324A, IF 1:1,000, WB 1:1000; Bethyl Laboratories), Cep152 (A302–480A ...
• Mutant huntingtin exon-1 impaired GTPCH and DHFR expression in plants and mice

  Chiu-Yueh Hung, et al., bioRxiv - Molecular Biology 2022

  Quote: ... Anti-GCH-1 (A305-296A-M-1) was obtained from Bethyl Laboratories ...
• Condensin II activation by M18BP1

  Alessandro Borsellini, et al., bioRxiv - Cell Biology 2024

  Quote: ... CAP-H2 (A302-275A, Bethyl Laboratories, 1:500 and 1:1000), GFP (Musacchio Lab ...
• SARS-CoV-2 predation of Golgi-bound PI4P primes the massive activation of the DNA Damage Response kinase ATM in the cytoplasm

  Antoine Rebendenne, et al., bioRxiv - Microbiology 2024

  Quote: anti-P-Ser824-KAP-1 (BETA300-767A, Bethyl, WB 1/2,000),
• Overarching control of autophagy and DNA damage response by CHD6 revealed by modeling a rare human pathology

  Yulia Kargapolova, et al., bioRxiv - Cell Biology 2020

  Quote: ... and immunoprecipitations were carried out by adding 4 μg of the appropriate antisera (CHD6, Bethyl A301-221A; TF3B, Bethyl A303-673A) to ~30 μg of chromatin and incubating on a rotator overnight at 4°C in the presence of protease inhibitors ...
• Fused in sarcoma regulates DNA replication timing and progression

  Weiyan Jia, et al., bioRxiv - Genomics 2020

  Quote: ... Digested lysates were briefly sonicated using a 10s/50s on/off cycle for three times at 40% power and clarified by centrifugation at 20,000g for 10 min at 4°C and supernatants were incubated with 10 μg FUS antibody (Bethyl, A300-302A) overnight at 4°C with rotation ...
• Integrated hiPSC-based liver and heart microphysiological systems predict unsafe drug-drug interaction

  Felipe T. Lee-Montiel, et al., bioRxiv - Bioengineering 2020

  Quote: ... Cells were then fixed with 4% PFA for 20 minutes at room temperature and labeled with the following antibodies: Anti-human albumin (A80-129A; Bethyl Laboratories) detected with a secondary antibody conjugated with Alexa-488 (Life Technologies ...
• Overarching control of autophagy and DNA damage response by CHD6 revealed by modeling a rare human pathology

  Yulia Kargapolova, et al., bioRxiv - Cell Biology 2020

  Quote: ... and immunoprecipitations were carried out by adding 4 μg of the appropriate antisera (CHD6, Bethyl A301-221A; TF3B, Bethyl A303-673A) to ~30 μg of chromatin and incubating on a rotator overnight at 4°C in the presence of protease inhibitors ...
• Transcription factor RFX7 governs a tumor suppressor network in response to p53 and stress

  Luis Coronel, et al., bioRxiv - Genomics 2021

  Quote: ... following the manufacturer instructions. 3 µg of p53 (kind gift from Dr. Bernhard Schlott (24)) or RFX7 (#A303-062A Bethyl Laboratories, Montgomery, TX, USA) antibody were used per IP ...
• The Epstein-Barr virus ubiquitin deconjugase BPLF1 regulates the activity of Topoisomerase II during virus replication

  Jinlin Li, et al., bioRxiv - Microbiology 2021

  Quote: ... rabbit anti-TOP1 (A302-589A,1:5000), TOP2α (A300-054A, 1:4000), TOP2β (A300-950A, 1:2000) and 53BP1(A300-272A,1:150) were from Bethyl Laboratories (Montgomery ...
• NF1 regulates mesenchymal glioblastoma plasticity and aggressiveness through the AP-1 transcription factor FOSL1

  Carolina Marques, et al., bioRxiv - Cancer Biology 2020

  Quote: ... NF1 (Santa Cruz #sc-67, 1:500; Bethyl #A300-140A, 1:1000), OLIG2 (Millipore #AB9610 ...
• The Splicing Factor XAB2 interacts with ERCC1-XPF and XPG for RNA-loop processing during mammalian development

  Evi Goulielmaki, et al., bioRxiv - Genetics 2020

  Quote: ... XPC (wb: 1:1000) and CSB (wb: 1:1000) were from Bethyl Laboratories ...
• DNA replication fork speed Acts as an Engine in Cortical Neurogenesis

  Jianhong Wang, et al., bioRxiv - Neuroscience 2024

  Quote: ... Rabbit polyclonal anti-Phospho-KAP-1(Ser824) (1:500, Bethyl, A300-767A); Rabbit anti-IBA1/AIF1 (1:500 ...
• Recurrent Integration of Human Papillomavirus Genomes at Transcriptional Regulatory Hubs

  Alix Warburton, et al., bioRxiv - Cancer Biology 2021

  Quote: ... Chromatin samples (25 μg per ChIP) were incubated overnight at 4°C with an antibody against FANCD2 (Bethyl, A302-174A, 2.5 μg). Rabbit IgG (Jackson ImmunoRes ...
• Localization of Kif1c mRNA to cell protrusions dictates binding partner specificity of the encoded protein

  Megan L. Norris, Joshua T. Mendell, bioRxiv - Molecular Biology 2022

  Quote: ... 4.5-5 mg total protein were used for each replicate with 4 ug of KIF1C antibody (Bethyl Kif1c/LTXS1 antibody, A301-072A). For western blots ...
• Ribosome biogenesis is a downstream effector of the oncogenic U2AF1-S34F mutation

  Abdalla Akef, et al., bioRxiv - Cell Biology 2020

  Quote: ... TP53 (Bethyl, 1:500), Cyclin A2 (BD Biosciences ...
• Functionally distinct roles for eEF2K in the control of ribosome availability and p-body abundance in sensory neurons

  Patrick R. Smith, et al., bioRxiv - Molecular Biology 2021

  Quote: ... RPL5 (Bethyl, 1:1000), RPS6 (CST ...
• Serine arginine-rich splicing factor (SRSF7) cooperates with the histone methyltransferase KMT5a to promote the type I interferon response via transcriptional activation of IRF7

  Haley M. Scott, et al., bioRxiv - Immunology 2023

  Quote: ... SRSF7 (Bethyl 1:3000) ZBP1 (Santa Cruz Biotechnologies ...
• Serine arginine-rich splicing factor (SRSF7) cooperates with the histone methyltransferase KMT5a to promote the type I interferon response via transcriptional activation of IRF7

  Haley M. Scott, et al., bioRxiv - Immunology 2023

  Quote: ... IRF3 (Bethyl, 1:1000); ANTI-FLAG M2 (Sigma Aldrich ...
• Modulation of ribosomal subunit associations by eIF6 is critical for mitotic exit and cancer progression

  Poonam Roshan, et al., bioRxiv - Molecular Biology 2024

  Quote: ... RPL23 (1:2500, Bethyl), β-Tubulin (1:2500 ...
• Modulation of ribosomal subunit associations by eIF6 is critical for mitotic exit and cancer progression

  Poonam Roshan, et al., bioRxiv - Molecular Biology 2024

  Quote: ... eIF2A (1:1000, Bethyl), eIF4G1 (1:1000 ...
• Modulation of ribosomal subunit associations by eIF6 is critical for mitotic exit and cancer progression

  Poonam Roshan, et al., bioRxiv - Molecular Biology 2024

  Quote: ... BCCIP (1:1500; Bethyl), eIF4E (1:1000 ...
• Modulation of ribosomal subunit associations by eIF6 is critical for mitotic exit and cancer progression

  Poonam Roshan, et al., bioRxiv - Molecular Biology 2024

  Quote: ... EFL1 (1:2500, Bethyl), phospho-Ser-10-Histone H3 (1:1000 ...
• Modulation of ribosomal subunit associations by eIF6 is critical for mitotic exit and cancer progression

  Poonam Roshan, et al., bioRxiv - Molecular Biology 2024

  Quote: ... eIF4G2 (1:4000, Bethyl), SBDS (1 ...
• Loss of Neurofibromin Induces Inflammatory Macrophage Phenotypic Switch and Retinal Neovascularization via GLUT1 Activation

  Yusra Zaidi, et al., bioRxiv - Cell Biology 2024

  Quote: ... Neurofibromin (Bethyl 1:1000), Mouse GAPDH (Santa Cruz ...
• Distinct Perception Mechanisms of BACH1 Quaternary Structure Degrons by Two F-box Proteins under Oxidative Stress

  Shiyun Cao, et al., bioRxiv - Cancer Biology 2024

  Quote: ... Bach1 (1:1000, Bethyl), HO-1 (1:1000 ...
• Expandable, Functional Hepatocytes Derived from Primary Cells Enable Liver Therapeutics

  Sunil K. Mallanna, et al., bioRxiv - Bioengineering 2024

  Quote: ... α1-antitrypsin (Bethyl Laboratory), and Factor-IX (Abcam ...
• mir-21 is associated with inactive low molecular weight Argonaute complexes in thyroid cancer cell lines

  Bonita H. Powell, et al., bioRxiv - Molecular Biology 2020

  Quote: ... RPL26 1:1000 dilution (Bethyl A300-686A-M Lot#A300-686A-M-1), Actin 1:10,000 dilution (Sigma A1978-100μL Lot#065M4837V) ...
• Intimate functional interactions between TGS1 and the Smn complex revealed by an analysis of the Drosophila eye development

  Paolo Maccallini, et al., bioRxiv - Genetics 2020

  Quote: ... rabbit anti-human TGS1 (1:1500, Bethyl Laboratories Cat#A300-814A, lot 1), rabbit anti-GFP antibody (1:1000 ...
• Atm loss does not radiosensitize a primary mouse model of Pten-deleted brainstem glioma

  Connor E. Stewart, et al., bioRxiv - Cancer Biology 2022

  Quote: ... rabbit polyclonal anti-KAP-1(phospho-S824) 1:200 (Bethyl Laboratories A300-767A), and rat monoclonal anti-mouse Ki67 1:200 (BioLegend 652402) ...
• Mediator of DNA damage checkpoint 1 (MDC1) is a novel estrogen receptor co-regulator in invasive lobular carcinoma of the breast

  Evelyn K. Bordeaux, et al., bioRxiv - Cancer Biology 2020

  Quote: ... Antigen retrieval used citrate buffer pH9.0 with 30’ incubation, followed by staining for ER (SP1, 1:100) or MDC1 (Abcam ab11171, 1:500; Bethyl A300-051, 1:1000). Staining was assessed by a board-certified pathologist (SM ...
• The deubiquitinase Usp9x regulates PRC2-mediated chromatin reprogramming during mouse development

  Trisha A. Macrae, Miguel Ramalho-Santos, bioRxiv - Molecular Biology 2020

  Quote: ... 1 mM EGTA) and rotated 4h-overnight with 1 µg Rb anti-Usp9x (Bethyl), 1.7 µg Rb anti-Ezh2 (CST #5246) ...
• Targeting RNA:Protein Interactions with an Integrative Approach Leads to the Identification of Potent YB-1 Inhibitors

  Krystel El Hage, et al., bioRxiv - Biophysics 2022

  Quote: ... Immunofluorescence was performed with anti-YB-1-1 (rabbit polyclonal, Bethyl Laboratories, Montgomery, USA), anti-YB-1-2 (Anti-YBX1 antibody produced in rabbit ...
• SARS-CoV-2 nucleocapsid protein inhibits the PKR-mediated integrated stress response through RNA-binding domain N2b

  Chiara Aloise, et al., bioRxiv - Microbiology 2023

  Quote: ... goat anti-eIF3η (1:200, SantaCruz) and rabbit anti-G3BP2 (1:200; Bethyl Laboratories) for 1h at room temperature (RT) ...
• Tripartite Inhibition of SRC-WNT-PKC Signalling Consolidates Human Naïve Pluripotency

  Jonathan Bayerl, et al., bioRxiv - Developmental Biology 2020

  Quote: ... NAANOG (397A; 1:1,000; Bethyl), METTL3 (A301-567A ...
• Loss of Foxc1 and Foxc2 function in chondroprogenitor cells disrupts endochondral ossification

  Asra Almubarak, et al., bioRxiv - Developmental Biology 2021

  Quote: ... Ki67 (Bethyl, IHC00075, 1:100). Antibodies against GFP were a generous gift from Dr Luc Berthiume (University of Alberta ...
• Identification of proximal SUMO-dependent interactors using SUMO-ID

  Orhi Barroso-Gomila, et al., bioRxiv - Biochemistry 2021

  Quote: ... anti-PML (1/1000) (Bethyl); anti-GFP (1/1000 ...
• Rescue of two trafficking-defective variants of the neuronal glycine transporter GlyT2 associated to hyperekplexia

  Andrés de la Rocha-Muñoz, et al., bioRxiv - Neuroscience 2021

  Quote: ... anti-rabbit (1:8,000; Bethyl) or anti-mouse IgG (1:8,000 ...
• Receptor-like role for PQLC2 amino acid transporter in the lysosomal sensing of cationic amino acids

  Gabriel Talaia, Joseph Amick, Shawn M. Ferguson, bioRxiv - Cell Biology 2020

  Quote: ... SMCR8 (Bethyl Laboratories, 1:4000) and GST (Rabbit anti-GST antibody raised against full-length recombinant Schistosoma japonicum GST ...
• Disruption of HIF1Α translational control attenuates the HIF-dependent hypoxic response and solid tumour formation in vivo

  Jill E Hunter, et al., bioRxiv - Cancer Biology 2022

  Quote: ... YB-1 (A303–231A, Bethyl), YB-1 (#4202 ...
• CHK2 Regulates MUS81-EME2 Function in Response to Replication Stress and BRCA2 Deficiency

  Eva Malacaria, et al., bioRxiv - Cell Biology 2022

  Quote: ... anti-SMARCAL1 (Bethyl, 1:2000), anti-GFP (Santa Cruz Biotechnology ...
• CHK2 Regulates MUS81-EME2 Function in Response to Replication Stress and BRCA2 Deficiency

  Eva Malacaria, et al., bioRxiv - Cell Biology 2022

  Quote: ... anti-BRCA2 (Bethyl, 1:2000), anti-pCHK2 (Millipore ...