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51 - 100 of 161 citations for 6 Bromo 2 trifluoromethylimidazo 1 2 a pyridine since 2019

• Determining distinct roles of IL-1α through generation of an IL-1α knockout mouse with no defect in IL-1β expression

  R.K. Subbarao Malireddi, et al., bioRxiv - Cell Biology 2022

  Quote: ... caspase-1 (AG-20B-0042; Adipogen), NLRP3 (AG-20B-0014 ...
• Cellular RNA Interacts with MAVS to Promote Antiviral Signaling

  Nandan S. Gokhale, et al., bioRxiv - Immunology 2023

  Quote: ... mouse anti-MAVS (AdipoGen, 1:1000), rabbit anti-TRAF2 (CST ...
• The integration of network biology and pharmacophore modeling suggests repurposing Clindamycin as an inhibitor of pyroptosis via Caspase-1 blockage in tumor-associated macrophages

  Adrian Weich, et al., bioRxiv - Systems Biology 2024

  Quote: ... ASC (AL177, AdipoGen/Biomol, 1:1000) (1:2.500 ...
• The autophagy activator Spermidine reduces neuroinflammation and soluble amyloid beta in an Alzheimer’s disease mouse model

  Kiara Freitag, et al., bioRxiv - Neuroscience 2021

  Quote: ... NLRP3 (1:500, AdipoGen, AG- 20B-0014), Gasdermin D (1:500 ...
• Exon Junction Complex dependent mRNA localization is linked to centrosome organization during ciliogenesis

  Oh Sung Kwon, et al., bioRxiv - Cell Biology 2020

  Quote: ... α-Polyglutamylated tubulin (ADIPOGEN, Mouse IgG1, 1:500), α-Y14 (Santacruz ...
• Steroid hormone catabolites activate the pyrin inflammasome through a non-canonical mechanism

  Flora Magnotti, et al., bioRxiv - Immunology 2021

  Quote: ... anti-Pyrin (Adipogen, AL196, 1: 1,000 dilution), anti-phospho S242 Pyrin (Abcam ...
• Hepatitis C virus infection is inhibited by a non-canonical antiviral signaling pathway targeted by NS3-NS4A

  Christine Vazquez, Chin Yee Tan, Stacy M. Horner, bioRxiv - Microbiology 2019

  Quote: ... mouse anti-RIG-I (1:1000, Adipogen), anti-Flag-HRP (1:2500 ...
• The lipid peroxidation product 4-hydroxynonenal inhibits NLRP3 inflammasome activation and macrophage pyroptosis

  Chia George Hsu, et al., bioRxiv - Immunology 2022

  Quote: ... Caspase-1(AdipoGen, AG-20B-0042-C100) 1:1000 ...
• The autophagy activator Spermidine ameliorates Alzheimer’s disease pathology and neuroinflammation in mice

  Kiara Freitag, et al., bioRxiv - Neuroscience 2020

  Quote: ... NLRP3 (1:500, AdipoGen, AG-20B-0014), Gasdermin D (1:500 ...
• Targeting of the NLRP3 Inflammasome for early COVID-19

  Carlo Marchetti, et al., bioRxiv - Immunology 2021

  Quote: ... Primary antibodies for NLRP3 1:1000 (Adipogen) was used in combination with peroxidase-conjugated secondary antibodies and chemiluminescence to detect the protein concentration ...
• ARMC9 and TOGARAM1 define a Joubert syndrome-associated protein module that regulates axonemal post-translational modifications and cilium stability

  Brooke L. Latour, et al., bioRxiv - Genetics 2019

  Quote: ... (Adipogen, AG- 20B-0020-C100, 1:2000), mouse anti-acetylated tubulin (clone 6-11-B1 ...
• Polyglutamylation of microtubules drives neuronal remodeling

  Antoneta Gavoci, et al., bioRxiv - Cell Biology 2024

  Quote: ... anti-GT335 (Adipogen, Mouse IgG1, 1: 200), anti-polyE (Adipogen ...
• CD4+ T Cell Depletion Before Primary Dengue and/or Secondary Zika Infection Reveals Mechanistic Correlates of Antibody Functionality in Rhesus Macaques

  Crisanta Serrano-Collazo, et al., bioRxiv - Immunology 2024

  Quote: ... and CD38- APC (AT-1) from Adipogen.
• Caspase-8-mediated CYLD Cleavage boosts LPS-induced Endotoxic Shock

  Jianling Liu, et al., bioRxiv - Immunology 2024

  Quote: ... Caspase1 (1:2000, Adipogen, AG-20B-0042), GSDMD (1:2000 ...
• SLC15A4 favors inflammasome function via mTORC1 signaling and autophagy restraint in dendritic cells

  Cynthia López-Haber, et al., bioRxiv - Immunology 2022

  Quote: ... Mouse monoclonal anti-caspase-1 p20 (Casper-1) and rabbit polyclonal anti-ASC (AL177) were from Adipogen (San Diego, CA); rabbit polyclonal anti-LC3B (ab48394 ...
• Pyruvate dehydrogenase kinase supports macrophage NLRP3 inflammasome activation during acute inflammation

  Allison K. Meyers, et al., bioRxiv - Immunology 2021

  Quote: ... ASC (Adipogen, no. AG-25B-0006; 1:1000), PDHe1α (ThermoFisher ...
• Cryo-electron tomography of ASC signalling sites in pyroptotic cells

  Yangci Liu, et al., bioRxiv - Immunology 2021

  Quote: ... 1:200 dilution (AdipoGen, AG-25B-0006, RRID:AB_2490440); rabbit anti-ASC monoclonal ASC/TMS1(D2W8U) ...
• NLRP3 inflammasome priming and activation are regulated by a novel phosphatidylinositol-dependent mechanism

  Claire Hamilton, et al., bioRxiv - Immunology 2021

  Quote: ... NLRP3 (1:2000, AdipoGen #AG-20B-0014-C100), ASC (1:2000 ...
• Pathogenic, but not non-pathogenic, Rickettsia evade inflammasome-dependent IL-1 responses to establish an intracytosolic replication niche

  Oliver H. Voss, et al., bioRxiv - Microbiology 2022

  Quote: ... αCaspase (Casp)-1 Ab was purchased from Adipogen, while αCasp-11 [EPR18628] and αGsdmd [EPR19828] Abs were obtained from Abcam ...
• Caspase-8 Modulates Angiogenesis By Regulating A Cell Death Independent Pathway In Endothelial Cells

  Nathalie Tisch, et al., bioRxiv - Developmental Biology 2019

  Quote: ... c-FLIP (1:1000, AG-20B-0056, AdipoGen).
• Inhibition of Bruton’s tyrosine kinase activity attenuates trauma-induced multiple organ dysfunction in rats

  Nikita M Patel, et al., bioRxiv - Pharmacology and Toxicology 2021

  Quote: ... and mouse anti-caspase 1 (p20) (from Adipogen). Detailed description of the method can be found in the supplemental section.
• Identification of Fluoxetine as a direct NLRP3 inhibitor to treat atrophic macular degeneration

  Meenakshi Ambati, et al., bioRxiv - Immunology 2021

  Quote: ... incubated with anti-ASC antibody (Adipogen; 1:300) with blocking buffer ...
• Aberrant localization of CDC42 C-terminal variants to the Golgi apparatus drives pyrin inflammasome-dependent autoinflammation

  Masahiko Nishitani-Isa, et al., bioRxiv - Immunology 2021

  Quote: ... rabbit polyclonal anti-human pyrin (AdipoGen, 1:2000), mouse monoclonal anti Rho-GDI (Santa-Cruz Biotechnology ...
• Pyruvate dehydrogenase kinase supports macrophage NLRP3 inflammasome activation during acute inflammation

  Allison K. Meyers, et al., bioRxiv - Immunology 2021

  Quote: ... NLRP3 (Adipogen, no. AG-20B-0014; 1:1000), ASC (Adipogen ...
• NLRP3 inflammasome priming and activation are regulated by a novel phosphatidylinositol-dependent mechanism

  Claire Hamilton, et al., bioRxiv - Immunology 2021

  Quote: ... ASC (1:2000, Adipogen #AG-25B-0006, AL177), GSDMD (1:1000 ...
• High Resolution Kinetic Characterization and Dynamic Mathematical Modeling of the RIG-I Signaling Pathway and the Antiviral Responses

  Sandy S. Burkart, et al., bioRxiv - Immunology 2022

  Quote: ... RIG-I (Adipogen, AG-20B-0009, 1:1000), STAT1 (BD ...
• Candida auris evades innate immunity by using metabolic strategies to escape and kill macrophages while avoiding antimicrobial inflammation

  Harshini Weerasinghe, et al., bioRxiv - Microbiology 2023

  Quote: ... anti-caspase-1 (Adipogen, #AG-20B-0042-C100) and anti-GSDMD (abcam ...
• Caspase-8-mediated CYLD Cleavage boosts LPS-induced Endotoxic Shock

  Jianling Liu, et al., bioRxiv - Immunology 2024

  Quote: ... NLRP3 (1:2000, Adipogen, AG-20B-0014-C100), Caspase11 (1:2000 ...
• Cancer Prognosis According to Parthanatos Features

  Alessandra Messikommer, et al., bioRxiv - Cancer Biology 2021

  Quote: ... monoclonal mouse anti-PAR antibody (10H, 1:300, Adipogen). Secondary antibodies used ...
• Signaling from the RNA sensor RIG-I is regulated by ufmylation

  Daltry L. Snider, et al., bioRxiv - Immunology 2022

  Quote: ... anti-RIG-I (M-AdipoGen, R-Abcam, 1:1000), R-anti-14-3-3ε (Cell Signaling Technology ...
• Microtubule glycylation promotes basal body attachment to the cell cortex

  Anthony D. Junker, et al., bioRxiv - Cell Biology 2019

  Quote: ... α-glutamylation (1:1000; GT335; Adipogen; (Wolff et al., 1992)) ...
• Hepatitis C virus infection is inhibited by a non-canonical antiviral signaling pathway targeted by NS3-NS4A

  Christine Vazquez, Chin Yee Tan, Stacy M. Horner, bioRxiv - Microbiology 2019

  Quote: ... mouse anti-HCV NS3 (Genotype 1B, 1:1000, Adipogen), mouse anti-HCV NS5A (Genotype 2A ...
• Aldehyde dehydrogenase 3A1 deficiency leads to mitochondrial dysfunction and impacts salivary gland stem cell self-renewal, differentiation and survival

  Vignesh Viswanathan, et al., bioRxiv - Cell Biology 2021

  Quote: JC-1 assay (Adipogen life sciences, San Diego, CA) was used to assess mitochondrial membrane potential ...
• In situ architecture of the ciliary base reveals the stepwise assembly of IFT trains

  Hugo van den Hoek, et al., bioRxiv - Cell Biology 2021

  Quote: ... or anti-PolyE (1:500, AdipoGen, AG-25B-0030). After 30 min of washing in PBS with 0.1% Tween-20 (PBST) ...
• Fas-threshold signalling in MSCs causes tumour progression and metastasis

  Andrea Mohr, et al., bioRxiv - Cancer Biology 2020

  Quote: ... multimeric FasL and anti-APO-1-3 from AdipoGen Life Sciences (San Diego ...
• ALS monocyte-derived microglia reveal cytoplasmic TDP-43 accumulation, DNA damage, and cell-specific impairment of phagocytosis associated with disease progression

  Hazel Quek, et al., bioRxiv - Neuroscience 2020

  Quote: ... Anti-NLRP3 (AdipoGen, #AG-20B-0014-C100, 1:500) were incubated overnight ...
• ALS monocyte-derived microglia reveal cytoplasmic TDP-43 accumulation, DNA damage, and cell-specific impairment of phagocytosis associated with disease progression

  Hazel Quek, et al., bioRxiv - Neuroscience 2020

  Quote: ... Anti-ASC (AdipoGen, #AG-25B-0006-C100, 1:200), Anti-NLRP3 (AdipoGen ...
• Multiple viral microRNAs regulate interferon release and signaling early during infection with Epstein-Barr virus

  Mickaël Bouvet, et al., bioRxiv - Microbiology 2020

  Quote: ... RIG-I/DDX58 (Adipogen, #AG-20B-0009, 1:1000), and OAS2 (Santa Cruz ...
• CD169-mediated restrictive SARS-CoV-2 infection of macrophages induces pro-inflammatory responses

  Sallieu Jalloh, et al., bioRxiv - Immunology 2022

  Quote: ... mouse anti-RIG-I (AdipoGen, #20B-0009, 1:1000), rabbit anti-MDA-5 (Proteintech ...
• Synergism of TNF-α and IFN-γ triggers inflammatory cell death, tissue damage, and mortality in SARS-CoV-2 infection and cytokine shock syndromes

  Rajendra Karki, et al., bioRxiv - Immunology 2020

  Quote: ... caspase-8 (AdipoGen, AG-20T-0138-C100, 1:1000), cleaved caspase-8 CST ...
• Sub-centrosomal mapping identifies augmin-γTuRC as part of a centriole-stabilizing scaffold

  Nina Schweizer, et al., bioRxiv - Cell Biology 2020

  Quote: ... mouse anti-polyglutamylated tubulin (GT335, AdipoGen; ExM, 1:250), rabbit anti-NEDD1 4 (ExM ...
• Morphogenesis in Trypanosoma cruzi epimastigotes proceeds via a highly asymmetric cell division

  Paul C Campbell, Christopher L de Graffenried, bioRxiv - Microbiology 2023

  Quote: ... anti-polyglutamate chain IN105 (1:10,000 for IF) (Adipogen), 20H5 (1:1000 for IF ...
• MARCH5-dependent NLRP3 ubiquitination is an essential step for NEK7 docking on the mitochondria

  Yeon-Ji Park, et al., bioRxiv - Immunology 2023

  Quote: ... anti-mouse ASC (1:1,000 AG-25B-0006, Adipogen), anti-human ASC (1:1,000 ...
• Brazilin is a Natural Product Inhibitor of the NLRP3 Inflammasome

  Emily McMahon, et al., bioRxiv - Molecular Biology 2023

  Quote: ... Membranes were then washed with PBST (3x, 15 min) before incubation with either mouse anti-mouse NLRP3 monoclonal antibody (1 µg ml−1; Cryo2, Adipogen, G-20B-0014-C100), goat anti-mouse IL-1β polyclonal antibody (250 ng ml−1 ...
• Defective endosome-TGN retrograde transport promotes NLRP3 inflammasome activation

  Zhirong Zhang, et al., bioRxiv - Immunology 2021

  Quote: ... anti-mouse Caspase-1 p20 (AG-20B-0042-C100, AdipoGen); anti-ASC antibody (sc-22514 ...
• The inflammasome-activated cytokine IL-1β is targeted for ubiquitylation and proteasomal degradation to limit its inflammatory potential

  Swarna L. Vijayaraj, et al., bioRxiv - Immunology 2021

  Quote: ... pro- and cleaved Caspase-1 (Adipogen; AG-20B-0042-C100), pro-Caspase-8 (in-house) ...
• Local synchronization of cilia and tissue-scale cilia alignment are sufficient for global metachronal waves

  Christa Ringers, et al., bioRxiv - Cell Biology 2022

  Quote: ... Larvae were incubated with glutamylated tubulin (GT335, 1:400, Adipogen), and beta-catenin (#9562 ...
• RAB1B interacts with TRAF3 to promote antiviral innate immunity

  Dia C. Beachboard, et al., bioRxiv - Immunology 2019

  Quote: ... anti-MAVS (mouse-AdipoGen or rabbit-Bethyl Laboratories, 1:1000), R-anti-GAPDH (Cell Signaling Technology ...
• Ornithine Lipid Activates Both TLR4 and the non-canonical NLRP3 Inflammasome

  Malvina Pizzuto, et al., bioRxiv - Immunology 2022

  Quote: ... anti-NLRP3 mouse monoclonal (Adipogen AG-20B-0014 1:1000) or horseradish peroxidase (HRP)-conjugated anti-β-actin (sc-47778 Santa Cruz 1:25000) ...
• Calcineurin associates with centrosomes and regulates cilia length maintenance

  Eirini Tsekitsidou, et al., bioRxiv - Cell Biology 2022

  Quote: ... and mouse anti-polyglutamylated tubulin GT335 (1:500, AdipoGen, AG20B0020C100).