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201 - 250 of 469 citations for tert Butyl 10 oxo 4 9 diazaspiro 4.5 decane 4 carboxylate since 2020

• Integrating collecting systems in kidney organoids through fusion of distal nephron to ureteric bud

  Min Shi, et al., bioRxiv - Developmental Biology 2024

  Quote: ... 10 μM DAPT (Cayman Chemical) was added to the above culture medium for varying lengths of time between days 2-6 ...
• ADAM17-triggered TNF signalling protects the ageing Drosophila retina from lipid droplet mediated degeneration

  Sonia Muliyil, et al., bioRxiv - Neuroscience 2020

  Quote: ... 10 μm TAPI-1 (Cayman Chemicals) or DMSO (Sigma ...
• Screening for axon regeneration promoting compounds with human iPSC-derived motor neurons

  Tammy Szu-Yu Ho, et al., bioRxiv - Neuroscience 2021

  Quote: ... and 10 µM SB431542 (Cayman Chemical). In phase 1 ...
• Macrophages in the reticuloendothelial system inhibit the propagation phase of mouse apolipoprotein A-II amyloidosis

  Hiroki Miyahara, et al., bioRxiv - Molecular Biology 2021

  Quote: ... 10 nM VPS34-IN1 (Cayman Chemical), or 2 µM cytochalasin D (Cayman Chemical ...
• T helper cell-licensed mast cells promote inflammatory Th17 cells

  Edouard Leveque, et al., bioRxiv - Immunology 2021

  Quote: ... Sulprostone (10 nmol/L, Cayman Chemical), L902,688 (12 nmol/L ...
• T helper cell-licensed mast cells promote inflammatory Th17 cells

  Edouard Leveque, et al., bioRxiv - Immunology 2021

  Quote: ... Butaprost (10 µmol/L, Cayman Chemical), Sulprostone (10 nmol/L ...
• An Alzheimer’s disease risk variant in TTC3 modifies the actin cytoskeleton organization and the PI3K-Akt signaling pathway in iPSC-derived forebrain neurons

  Holly N. Cukier, et al., bioRxiv - Genetics 2023

  Quote: ... 10 nM Jasplakinolide (Cayman Chemical, # 11705) or 20 µM Y27632 (Biogems ...
• Beta-catenin mediates growth defects induced by centrosome loss in APC mutant colorectal cancer independently of p53

  Mohamed Bourmoum, et al., bioRxiv - Cancer Biology 2023

  Quote: ... XAV-939 (Cayman Chemical #13596-10), ICG-001 (Cayman Chemical #16257-5) ...
• Cis-vaccenic acid is a key product of stearoyl-CoA desaturase 1 and a critical oncogenic factor in prostate cancer

  Julia S Scott, et al., bioRxiv - Cell Biology 2024

  Quote: ... and 10 µM enzalutamide (Cayman Chemical) for enzalutamide-resistant cell lines (MR49F and V16D) ...
• Pathogenic soluble tau peptide disrupts endothelial calcium signaling and vasodilation in the brain microvasculature

  Kalev Freeman, et al., bioRxiv - Neuroscience 2023

  Quote: ... bradykinin (10 µM; Cayman Chemical, USA), NS309 (1 µM) ...
• A CPC-shelterin-BTR axis regulates mitotic telomere deprotection

  Diana Romero-Zamora, et al., bioRxiv - Molecular Biology 2024

  Quote: ... 10 µM XL413 (24906, Cayman Chemical), or 25 nM BAY181609 (A19868 ...
• RudLOV—a new optically synchronized cargo transport method reveals unexpected effect of dynasore

  Tatsuya Tago, et al., bioRxiv - Cell Biology 2023

  Quote: ... 10 μM of Dyngo4a (Cayman Chemical), 10 μM of dynole34-2 ...
• Uncovering the hidden threat: single-organoid analysis reveals clinically relevant treatment-resistant and invasive subclones in pancreatic cancer

  Maxim Le Compte, et al., bioRxiv - Cancer Biology 2023

  Quote: ... 10 μM Y-27632 (Cayman Chemicals) and 1:500 Primocin (Invivogen) ...
• Dephosphorylation of 4EBP1/2 Induces Prenatal Neural Stem Cell Quiescence

  Laura C. Geben, et al., bioRxiv - Developmental Biology 2023

  Quote: ... 10 μM SB431542 (Cayman Chemical, 13031) and 100 nM LDN-193189 (Tocris ...
• Episodic live imaging of cone photoreceptor maturation in GNAT2-EGFP retinal organoids

  Jinlun Bai, et al., bioRxiv - Developmental Biology 2023

  Quote: ... 10 µM SB431542 (Cayman Chemical, #13031), and 0.1 µM LDN193189 (SIGMA ...
• Small Molecule Activators of B56-PP2A Restore 4E-BP Expression and Function to Suppress Cap-dependent Translation in Cancer Cells

  Michelle A. Lum, et al., bioRxiv - Cancer Biology 2023

  Quote: ... 10 nM INK128 (Cayman Chemical Company), 20 μM DT-1310 ...
• The ATP-exporting channel Pannexin-1 promotes CD8⁺ T cell effector and memory responses

  Trupti Vardam-Kaur, et al., bioRxiv - Immunology 2024

  Quote: ... or SR13800 (10 μM, Cayman Chemical) were added to the cultures at the beginning of activation ...
• An iPSC model of fragile X syndrome reflects clinical phenotypes and reveals m⁶A-mediated epi-transcriptomic dysregulation underlying synaptic dysfunction

  Lu Lu, et al., bioRxiv - Neuroscience 2024

  Quote: ... or 10 μM STM2457 (Cayman Chemical) for 2 weeks ...
• Human Vascularized Macrophage-Islet Organoids to Model Immune-Mediated Pancreatic β cell Pyroptosis upon Viral Infection

  Liuliu Yang, et al., bioRxiv - Developmental Biology 2024

  Quote: ... and 10 µM SB431542 (Cayman Chemical). On day 5 and 7 ...
• Rapid metabolic regulation of a novel arginine methylation of KCa3.1 attenuates T cell exhaustion

  Piyush Sharma, et al., bioRxiv - Immunology 2024

  Quote: ... 10 µl of the 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate (AQC, 10 mM in acetonitrile)-derivatizing reagent (Cayman Chemical) was added ...
• Filopodia-based contact stimulated collective migration drives tissue morphogenesis

  Maik C. Bischoff, et al., bioRxiv - Cell Biology 2020

  Quote: ... para-nitro-blebbistatin (10 μM, Cayman Chemical), Rok inhibitor Y-27632 (10 μM ...
• Quantitative intravital imaging reveals in vivo dynamics of physiological-stress induced mitophagy

  Paul J. Wrighton, et al., bioRxiv - Cell Biology 2020

  Quote: ... or 10 μM FG-4592 (Cayman Chemical) in E3 from about 70 hpf to 98 hpf ...
• A model of traumatic brain injury using human iPSC-derived cortical brain organoids

  Jesse D. Lai, et al., bioRxiv - Neuroscience 2020

  Quote: ... and 10 μM SB-431542 (Cayman Chemicals) in DMEM/F12 containing 20% KnockOut Serum (Gibco) ...
• Yap/Taz-Activated Tert-Expressing Acinar Cells Are Required for Pancreatic Regeneration

  Han Na Suh, et al., bioRxiv - Cell Biology 2021

  Quote: ... 10 μM Y-27632 (Cayman Chemical 10005583), and 1mM Jagged-1 (AnaSpec AS-61298) ...
• Self-organizing Single-Rosette Brain Organoids from Human Pluripotent Stem Cells

  Andrew M. Tidball, et al., bioRxiv - Neuroscience 2022

  Quote: ... and 10 µM SB431542 (Cayman Chemical, 13031) (2 mL of media per well) ...
• Chiral growth of adherent filopodia

  Wenhong Li, et al., bioRxiv - Cell Biology 2022

  Quote: ... 10 mM thiodigalactoside (TDG) (17154, Cayman Chemical) was added to cells in suspension and incubated for 10 minutes at 37°C before the cells were seeded on the substrates in the medium containing the same concentration of TDG.
• CD28 costimulatory domain protects against tonic signaling-induced functional impairment in CAR-Tregs

  Baptiste Lamarthee, et al., bioRxiv - Immunology 2020

  Quote: ... Prostaglandin E2 (PGE2) (Cayman Chemical, 10 µM) and a transduction adjuvant (Lentiboost ...
• Kv4.3 channel downregulation mediates chronic post-lesional pacemaker acceleration in surviving dopamine substantia nigra neurons

  Lora Kovacheva, et al., bioRxiv - Neuroscience 2021

  Quote: ... and DL-AP5 (10 µM; Cayman Chemical) were added to inhibit excitatory and inhibitory synaptic transmission ...
• γδ T cells are effectors of immune checkpoint blockade in mismatch repair-deficient colon cancers with antigen presentation defects

  Natasja L. de Vries, et al., bioRxiv - Cancer Biology 2021

  Quote: ... and 10 nM prostaglandin E2 (Cayman Chemicals). Organoids were passaged depending on growth every 1–2 weeks by incubating in TrypLE Express (Gibco ...
• Biochemical reactions between intra-articular tissues and joint instability in a rat model of osteoarthritis

  Kenji Murata, et al., bioRxiv - Pathology 2023

  Quote: ... SB-431542 (10 μM) (Cayman Chemical, USA) was used to selectively inhibit TGF-β1/ALK5-smad2/3 signaling cascade ...
• HMGB1 acts as an agent of host defense at the gut mucosal barrier

  A-M C Overstreet, et al., bioRxiv - Microbiology 2023

  Quote: ... 10 nM Y-27632 (Cayman Chemical Company), and 100 ng/mL R-spondin 1 (Peprotech) ...
• Amyloid-beta peptides 40 and 42 employ distinct molecular pathways for cell entry and intracellular transit at the BBB endothelium

  Zengtao Wang, et al., bioRxiv - Neuroscience 2022

  Quote: ... 10 μM cytochlasin A (Cayman Chemical, MI) (actin inhibitor) ...
• Mitochondrial Apolipoprotein MIC26 is a metabolic rheostat regulating central cellular fuel pathways

  Melissa Lubeck, et al., bioRxiv - Cell Biology 2023

  Quote: ... BODIPY 493/503 (Cayman Chemicals, 10 µM) respectively for 30 min at 37°C ...
• Inhibition of Parkinson’s Disease-related LRRK2 by type-I and type-II kinase inhibitors: activity and structures

  Marta Sanz Murillo, et al., bioRxiv - Biophysics 2023

  Quote: ... and GZD-824 (10 mM; Cayman Chemical), were stored in DMSO at -20 C.
• Pyruvate Kinase Activity Regulates Cystine Starvation Induced Ferroptosis through Malic Enzyme 1 in Pancreatic Cancer Cells

  Elliot Ensink, et al., bioRxiv - Cancer Biology 2023

  Quote: ... 10 μM compound 3k (36815, Cayman Chemical), 50 μM Malic enzyme inhibitor (HY-124861 ...
• Pyruvate Kinase Activity Regulates Cystine Starvation Induced Ferroptosis through Malic Enzyme 1 in Pancreatic Cancer Cells

  Elliot Ensink, et al., bioRxiv - Cancer Biology 2023

  Quote: ... 10 μM Necrostatin-1S (20924, Cayman Chemical), 0.16 – 50 μM IKE (27088 ...
• Pla2g12b is Essential for Expansion of Nascent Lipoprotein Particles

  James H. Thierer, et al., bioRxiv - Cell Biology 2022

  Quote: ... Nocodazole (10 mg/mL, Cayman Chemical, #13857), and Thapsigargin (2 mM ...
• Improving stem cell-derived pancreatic islets using single-cell multiome-inferred regulomes

  Han Zhu, et al., bioRxiv - Cell Biology 2022

  Quote: ... 10 µM ALK5i II (Cayman Chemicals, 14794), 10 µM ZnSO4 (Sigma ...
• Atypical peripheral actin band formation via overactivation of RhoA and Non-muscle myosin II in Mitofusin 2 deficient cells

  Yueyang Wang, et al., bioRxiv - Cell Biology 2022

  Quote: ... 10 μM BMS-5 (Cayman Chemical, #21072) or 2 μM ML-7 (Cayman Chemical ...
• IL-33-induced neutrophilic inflammation and NETosis underlie rhinovirus-triggered exacerbations of asthma

  Bodie Curren, et al., bioRxiv - Immunology 2022

  Quote: ... Cl-Amidine (Cayman Chemical; 10 mg/kg) or vehicle diluent (PBS ...
• Extracellular vesicle-associated cholesterol dictates the regenerative functions of macrophages in the brain

  Sam Vanherle, et al., bioRxiv - Neuroscience 2022

  Quote: ... T0901317 (10 µM, cat. #71810, Cayman Chemicals)
• Uncovering the hidden threat: single-organoid analysis reveals clinically relevant treatment-resistant and invasive subclones in pancreatic cancer

  Maxim Le Compte, et al., bioRxiv - Cancer Biology 2023

  Quote: ... and 10 μM Y-27632 (Cayman Chemicals). To prevent microbial contamination ...
• Novel lentiviral vectors for gene therapy of sickle cell disease combining gene addition and gene silencing strategies

  Mégane Brusson, et al., bioRxiv - Genetics 2022

  Quote: ... supplemented with 10 μM PGE2 (Cayman Chemical) and Lentiboost (1 mg/ml ...
• A new microphysiological system shows hypoxia primes human ISCs for interleukin-dependent rescue of stem cell activity

  Kristina R. Rivera, et al., bioRxiv - Cell Biology 2023

  Quote: ... 10 nM prostaglandin E2 (14010; Cayman Chemicals), 3.0 μM SB202190 (S1077 ...
• A Shared Pathogenic Mechanism for Valproic Acid and SHROOM3 Knockout in a Brain Organoid Model of Neural Tube Defects

  Taylor N. Takla, et al., bioRxiv - Neuroscience 2023

  Quote: ... and 10 µM SB431542 (Cayman Chemical, 13031) (2 mL of medium per well) ...
• The mitotic surveillance pathway requires PLK1-dependent 53BP1 displacement from kinetochores

  Matteo Burigotto, et al., bioRxiv - Cell Biology 2023

  Quote: ... 10 µM 3-MB-PP1 (Cayman Chemical). Thymidine was dissolved in water whereas all other drugs were dissolved in DMSO ...
• Secreted phospholipase PLA2G12A-driven lysophospholipid signaling via lipolytic modification of extracellular vesicles facilitates pathogenic Th17 differentiation

  Chika Mochizuki, et al., bioRxiv - Immunology 2024

  Quote: ... Cayman Chemical),10 µM KD025 (ROCK2 inhibitor, Cayman Chemical), 10 µM YM254890 (Gq inhibitor ...
• Excitatory Cortical Neurons from CDKL5 Deficiency Disorder Patient-Derived Organoids Show Early Hyperexcitability Not Identified in Neurogenin2 Induced Neurons

  Madison R. Glass, et al., bioRxiv - Neuroscience 2024

  Quote: ... 10 μM Y27632 (Cayman Chemical Company #10005583) was supplemented into the media for one day to improve cell survival ...
• Differential effects of statins on the anti-dyskinetic activity of sub-anesthetic ketamine

  Mitchell J. Bartlett, et al., bioRxiv - Neuroscience 2024

  Quote: ... lovastatin (10 mg/kg, i.p.; Cayman Chemicals), and L-DOPA (6 mg/kg ...
• LRRC8 complexes are adenosine nucleotide release channels regulating platelet activation and arterial thrombosis

  John D. Tranter, et al., bioRxiv - Cell Biology 2024

  Quote: ... ADP (10 – 20 µM, #21121, Cayman Chemical) with fibrinogen (30 µg/mL ...