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301 - 350 of 884 citations for 2 Chloro 3 6 chlorohexanoyl pyridine since 2020

• Translation of dipeptide repeat proteins in C9ORF72-ALS/FTD through unique and redundant AUG initiation codons

  Yoshifumi Sonobe, et al., bioRxiv - Molecular Biology 2022

  Quote: ... 2 µM DMH1 (Tocris Bioscience), and 2 µM SB431542 (Stemgent ...
• Brief synaptic inhibition persistently interrupts firing of fast-spiking interneurons

  Simon Chamberland, et al., bioRxiv - Neuroscience 2022

  Quote: ... CGP-55845 (2 μM, Tocris) dendrotoxin-K (50 nM ...
• An iPSC-derived small intestine-on-chip with self-organizing epithelial, mesenchymal and neural cells

  Renée Moerkens, et al., bioRxiv - Cell Biology 2024

  Quote: ... CHIR99021 (2 μM, Tocris, #4423), B27 (1x ...
• An iPSC-derived small intestine-on-chip with self-organizing epithelial, mesenchymal and neural cells

  Renée Moerkens, et al., bioRxiv - Cell Biology 2024

  Quote: ... CHIR99021 (2 μM, Tocris, #4423), B27 (1x,
• Synapse specific and plasticity-regulated AMPAR mobility tunes synaptic integration

  Agata Nowacka, et al., bioRxiv - Neuroscience 2024

  Quote: ... 0.002 2-chloroadenosine (Tocris, #3136). High Pr conditions aCSF contained 1 mM MgCl2 and 4 mM CaCl2 ...
• LINC complex alterations are a hallmark of sporadic and familial ALS/FTD

  Riccardo Sirtori, et al., bioRxiv - Neuroscience 2024

  Quote: ... and SB431542 (2 μM, Tocris). On day 7 and 13 ...
• SCN1A-deficient hiPSC-derived excitatory neuronal networks display mutation-specific phenotypes

  Eline J.H. van Hugte, et al., bioRxiv - Neuroscience 2023

  Quote: ... Levetiracetam (Tocris, #102767-28-2), Topiramate (Tocris ...
• The ALS/FTD-related C9orf72 hexanucleotide repeat expansion forms RNA condensates through multimolecular G-quadruplexes

  Federica Raguseo, et al., bioRxiv - Biochemistry 2023

  Quote: ... 2 μM SB431542 (Tocris Bioscience), and 3.3 μM CHIR99021 (Tocris Bioscience) ...
• Dissecting peri-implantation development using cultured human embryos and embryo-like assembloids

  Zongyong Ai, et al., bioRxiv - Developmental Biology 2023

  Quote: ... 2 μM Gö6983 (TOCRIS, 2285) and 10 ng/ml recombinant human LIF (Peprotech ...
• Extended regulation interface coupled to the allosteric network and disease mutations in the PP2A-B56δ holoenzyme

  Cheng-Guo Wu, et al., bioRxiv - Biochemistry 2023

  Quote: ... and 2 μM rolipram (Tocris) to activate adenylyl cyclase and inhibit cAMP phosphodiesterase 4 (PDE4 ...
• Recording morphogen signals reveals origins of gastruloid symmetry breaking

  Harold M. McNamara, et al., bioRxiv - Developmental Biology 2023

  Quote: ... 2 μM PD0325901 (Tocris, 4192), and 3 μM CHIR99021 (Tocris ...
• APOE Expression and Secretion are Modulated by Mitochondrial Dysfunction

  Meghan E. Wynne, et al., bioRxiv - Cell Biology 2022

  Quote: ... 2 μM dorsomorphin (Tocris, 3093) and 2 μM A-83 (Tocris ...
• Control of gastruloid patterning and morphogenesis by the Erk and Akt signaling pathways

  Evan J. Underhill, Jared E. Toettcher, bioRxiv - Developmental Biology 2023

  Quote: ... 2 μM PD0325901 (Tocris, 4192), and 3 μM CHIR99021 (Tocris ...
• Actin polymerization drives lumen formation in a human epiblast model

  Dhiraj Indana, et al., bioRxiv - Developmental Biology 2023

  Quote: ... ML-141 (2 µM; Tocris Bioscience 4266 ...
• Gravitational and mechanical forces drive mitochondrial translation through the cell adhesion–FAK axis

  Taisei Wakigawa, et al., bioRxiv - Molecular Biology 2023

  Quote: ... valinomycin (Tocris, 3373, 2 μM), sorafenib (Selleckchem ...
• Reuniens thalamus recruits recurrent excitation in medial prefrontal cortex

  Gil Vantomme, et al., bioRxiv - Neuroscience 2024

  Quote: ... 2 QX314-Cl (Tocris, 2313), pH 7.3 ...
• Intestine-on-chip enhances nutrient and drug metabolism and maturation of iPSC-derived intestinal epithelial cells relative to organoids and Transwells

  Renée Moerkens, et al., bioRxiv - Cell Biology 2024

  Quote: ... CHIR99021 (2 μM, Tocris, #4423), B27 (1x ...
• Stepwise developmental mimicry generates proximal-biased kidney organoids

  Jack Schnell, et al., bioRxiv - Developmental Biology 2024

  Quote: ... 2 µM DAPT (Tocris 2634), or both ...
• Intestine-on-chip enhances nutrient and drug metabolism and maturation of iPSC-derived intestinal epithelial cells relative to organoids and Transwells

  Renée Moerkens, et al., bioRxiv - Cell Biology 2024

  Quote: ... CHIR99021 (2 μM, Tocris, #4423), B27 (1x ...
• MJF-14 proximity ligation assay detects early non-inclusion alpha-synuclein pathology with enhanced specificity and sensitivity

  Nanna Møller Jensen, et al., bioRxiv - Neuroscience 2024

  Quote: ... 2 µM LM22A4 (Tocris Bioscience), 2.5 µM DAPT (Tocris Bioscience) ...
• The Parkinson’s Disease related mutant VPS35 (D620N) amplifies the LRRK2 response to endolysosomal stress

  Katy R. McCarron, et al., bioRxiv - Cell Biology 2024

  Quote: ... MLi-2 (Tocris Bioscience; 5756), nigericin sodium salt (Sigma-Aldrich ...
• Type-II kinase inhibitors that target Parkinson’s Disease-associated LRRK2

  Nicolai D. Raig, et al., bioRxiv - Cell Biology 2024

  Quote: ... 500 nM MLi-2 (Tocris), or various concentrations of RN277 or RN341 for 4 h at 37 °C and 5 % CO2 ...
• Group I p21-activated kinases in leukemia cell adhesion to fibronectin

  Kateřina Kuželová, et al., bioRxiv - Cell Biology 2020

  Quote: ... IPA-3 (#3622) and PIR3.5 (#4212) were purchased from Tocris Bioscience and dissolved in sterile dimethylsulfoxide (DMSO ...
• A dual mechanism of enhancer activation by FOXA pioneer factors induces endodermal organ fates

  Ryan J. Geusz, et al., bioRxiv - Genomics 2020

  Quote: ... consisting of cSFDM base supplemented with 3 µm CHIR99021 (Tocris), 10 ng/mL rhKGF (R&D Systems) ...
• PAK1 and PAK2 in cell metabolism regulation

  Tereza Kořánová, et al., bioRxiv - Cell Biology 2021

  Quote: IPA-3 (#3622) and PIR3.5 (#4212) were purchased from Tocris Bioscience and dissolved in sterile dimethylsulfoxide (DMSO ...
• An Rtn4/Nogo-A-interacting micropeptide modulates synaptic plasticity with age

  S. Kragness, et al., bioRxiv - Neuroscience 2022

  Quote: ... and 3) bath application of 1µM DCG-IV (0975, Tocris) at the end of LTP recording significantly reduced the evoked fEPSPs ...
• SARS-CoV-2 Infection of Pluripotent Stem Cell-derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response

  Jessie Huang, et al., bioRxiv - Molecular Biology 2020

  Quote: ... “CBRa” media consists of cSFDM containing 3 μm CHIR99021 (Tocris), 10 ng/mL recombinant human BMP4 (rhBMP4 ...
• Defining the signalling determinants of a posterior ventral spinal cord identity in human neuromesodermal progenitor derivatives

  Matthew Wind, et al., bioRxiv - Developmental Biology 2020

  Quote: ... day 3 hPSC-derived NMP-like cells were dissociated using Accutase and re-plated at a density of 37,500-86,000 cells /cm2 on Geltrex (Thermo Fisher)-coated plates directly in N2B27 containing CHIR99021 (3 µM, Tocris) and FGF2 (100 ng/ml ...
• Single-molecule imaging of telomerase RNA reveals a Recruitment – Retention model for telomere elongation

  Hadrien Laprade, et al., bioRxiv - Molecular Biology 2020

  Quote: ... cells were treated with 3 µM of KU60019 (Tocris Bioscience) for 24 hours ...
• Dopamine modulates adaptive forgetting in medial prefrontal cortex

  Francisco Tomás Gallo, et al., bioRxiv - Animal Behavior and Cognition 2021

  Quote: ... SCH 23389 (3 mg/ml in saline, Tocris #0925/10) and SKF 38393 (8.41 mg/ml in saline ...
• Graded heterogeneity of metabotropic signaling underlies a continuum of cell-intrinsic temporal responses

  Chong Guo, et al., bioRxiv - Neuroscience 2020

  Quote: ... mGluR2/3 antagonist (1μM LY341495, Tocris Bio-Techne, Minneapolis, MN) and DGK inhibitor II (100 μM R59949 ...
• The genetic basis of tail-loss evolution in humans and apes

  Bo Xia, et al., bioRxiv - Evolutionary Biology 2021

  Quote: ... and 3 µM GSK3 inhibitor CHIR99021 (Tocris, Cat. No. 4423). mESC medium was made from Knockout DMEM (Gibco ...
• A PTER-dependent pathway of taurine metabolism linked to energy balance

  Wei Wei, et al., bioRxiv - Biochemistry 2024

  Quote: ... Exendin-3 (9-39) amide (2081) was purchased from Tocris. Recombinant GDF15 (957-GD ...
• A multidimensional atlas of human glioblastoma organoids reveals highly coordinated molecular networks and effective drugs

  Changwen Wang, et al., bioRxiv - Cancer Biology 2023

  Quote: ... 3 μM of CHIR99021 (Tocris Bioscience, Minneapolis, USA, Cat#4423) and 1 μM of PD0325901 (Selleckchem ...
• Notch signalling influences cell fate decisions and HOX gene induction in axial progenitors

  Fay Cooper, et al., bioRxiv - Developmental Biology 2023

  Quote: ... The N2B27 medium was supplemented with CHIR (3 μM, Tocris), FGF2 (20 ng/ml ...
• Cross-species evidence for a developmental origin of adult hypersomnia with loss of synaptic adhesion molecules beat-Ia/CADM2

  Kyla Mace, et al., bioRxiv - Neuroscience 2024

  Quote: Peptide YY (3-36) (PYY) was obtained from Tocris (#1618) and dissolved in water to achieve a 100µM stock solution ...
• Development of LRRK2 designed ankyrin-repeat proteins

  Verena Dederer, et al., bioRxiv - Biochemistry 2023

  Quote: ... the cells were incubated at 37 °C with DMSO or MLi-2 (Tocris; 2 μM) for 2 hours ...
• A calibrated optogenetic toolbox of stable zebrafish opsin lines

  P Antinucci, et al., bioRxiv - Neuroscience 2020

  Quote: Zebrafish larvae (5–6 dpf) were first paralysed in 1 mM α-Bungarotoxin solution (Tocris) for 3–6 min after which they were pinned in a lateral position to a Sylgard-coated recording dish (Sylgard 184 ...
• Chronic chemogenetic activation of forebrain excitatory neurons in postnatal life evokes long-lasting changes in mood-related behavior

  Sthitapranjya Pati, et al., bioRxiv - Neuroscience 2020

  Quote: ... 6-Cyano-7-nitroquinoxaline-2,3-dione disodium (CNQX disodium salt; Cat. No. 1045, Tocris, UK), DL-2-Amino-5-phosphonopentanoic acid sodium salt (AP5 ...
• A neural hub that coordinates learned and innate courtship behaviors

  Mor Ben-Tov, Fabiola Duarte, Richard Mooney, bioRxiv - Neuroscience 2021

  Quote: ... The solution was PBS-based and included 10-60 mM 6-OHDA hydrochloride (Tocris, 2547), 10 μM l-ascorbic acid (Millipore/Sigma ...
• Reciprocal regulation of Shh trafficking and H₂O₂ levels via a noncanonical BOC-Rac1 pathway

  Marion Thauvin, et al., bioRxiv - Cell Biology 2021

  Quote: ... cells were pre-treated for 6 hours with 100 μM CPYPP (DOCK-i; No4568, Tocris). To inhibit Shh signaling ...
• Mature parvalbumin interneuron function in prefrontal cortex requires activity during a postnatal sensitive period

  Sarah E. Canetta, et al., bioRxiv - Neuroscience 2021

  Quote: ... 20 µM 6-cyano-7-nitroquinoxaline-2,3-dione disodium salt (CNQX, Tocris Bioscience, Briston, UK) and 50 µM D-(-)-2-amino-5-phosphonopentanoic acid (AP5 ...
• GLUT1 ablation in astrocytes paradoxically improves central and peripheral glucose metabolism via enhanced insulin-stimulated ATP release

  Carlos G. Ardanaz, et al., bioRxiv - Neuroscience 2022

  Quote: ... 6-N,N-Diethyl-β-γ-dibromomethylene-D-adenosine-5′-triphosphate (ARL 67156; Tocris, 1283) was perfused through the probe at concentrations of 1 mM ...
• Impairments in the early consolidation of spatial memories via group II mGluR agonism in the mammillary bodies

  Michal M. Milczarek, et al., bioRxiv - Animal Behavior and Cognition 2023

  Quote: ... receiving either eglumetad (6 mg/kg, 10.8 mM; also known as LY-354740, Tocris, UK) or saline vehicle injections ...
• GATA1 knockout in human pluripotent stem cells generates enhanced neutrophils to investigate extracellular trap formation

  Thomas C. Harper, et al., bioRxiv - Immunology 2023

  Quote: ... coated 6 cm dishes in mTeSR Plus media with 10 μM Y-27632 (Tocris, 1254). On Day 0 ...
• Induced pluripotent stem cell model revealed impaired neurovascular interaction in genetic small vessel disease CADASIL

  Wenjun Zhang, et al., bioRxiv - Cell Biology 2023

  Quote: ... E8 medium was replaced with E6 medium supplemented with 6 uM CHIR99021 (Tocris Bioscience, 4423), 20 ng/mL Bone Morphogenetic Protein 4 (rBMP4 ...
• Identification of a SARS-CoV-2 host metalloproteinase-dependent entry pathway differentially used by SARS-CoV-2 and variants of concern Alpha, Delta, and Omicron

  Mehdi Benlarbi, et al., bioRxiv - Microbiology 2022

  Quote: ... E64d and MMP-2/MMP-9 Inhibitor II were from MilliporeSigma and TAPI-2 from Tocris.
• Superoxide enters neurons via LRRC8A – containing volume-regulated anion channels

  Kate Harris, et al., bioRxiv - Neuroscience 2024

  Quote: ... 4-(2-Butyl-6,7-dichloro-2-cyclopentyl-indan-1-on-5-yl) oxobutyric acid (DCPIB; Tocris), superoxide dismutase (SOD ...
• Transcriptional networks predating cognition-associated pyramidal lineages are restructured by erythropoietin

  Manvendra Singh, et al., bioRxiv - Neuroscience 2023

  Quote: ... mIPSC were pharmacologically isolated by blocking glutamatergic EPSCs (2 µM NBQX and 2 µM CPP, Tocris) and were recorded using an internal solution consisting of (in mM ...
• Defining totipotency using criteria of increasing stringency

  Eszter Posfai, et al., bioRxiv - Cell Biology 2020

  Quote: ... 2 µM Dimethindene maleate (Tocris #1425); and 2 µM Minocycline Hydrochloride (Santa Cruz #sc-203339) ...