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501 - 550 of 1459 citations for 1R 2S 6R 7S 4 4 DIMETHYL 3 5 DIOXA 8 AZATRICYCLO 5.2.1.0 2 6 DECAN 9 ONE since 2020

• Robust three-dimensional expansion of human adult alveolar stem cells and SARS-CoV-2 infection

  Jeonghwan Youk, et al., bioRxiv - Cell Biology 2020

  Quote: ... and 3 μM CHIR99021 (Tocris)) was added to each lower chamber ...
• MRCK controls myosin II activation in the polarized cortex of mouse oocytes and promotes spindle rotation and male pronucleus centration

  Anne Bourdais, Benoit Dehapiot, Guillaume Halet, bioRxiv - Cell Biology 2022

  Quote: ... IPA-3 (1 μM; Tocris), BDP-9066 (1 μM ...
• Translation of dipeptide repeat proteins in C9ORF72-ALS/FTD through unique and redundant AUG initiation codons

  Yoshifumi Sonobe, et al., bioRxiv - Molecular Biology 2022

  Quote: ... 3 µM CHIR99021 (Tocris Bioscience), 2 µM DMH1 (Tocris Bioscience) ...
• Design, implementation, and functional validation of a new generation of microneedle 3D high-density CMOS multi-electrode array for brain tissue and spheroids

  Lisa Mapelli, et al., bioRxiv - Neuroscience 2022

  Quote: ... 3 μM TTX (tetrodotoxin, Tocris) was added to the Krebs solution ...
• An iPSC-derived small intestine-on-chip with self-organizing epithelial, mesenchymal and neural cells

  Renée Moerkens, et al., bioRxiv - Cell Biology 2024

  Quote: ... CHIR99021 (3 μM, Tocris, #4423) and defined FBS (2% vol/vol ...
• Inhibitory gating of thalamocortical inputs onto rat gustatory insular cortex

  Melissa S. Haley, et al., bioRxiv - Neuroscience 2022

  Quote: ... 3 QX-314 (Tocris Bioscience), 0.2% biocytin (Vrev [Cl−1] = −49.3mV) ...
• Rapamycin mitigates Valproic Acid-induced teratogenicity in human and animal models by suppressing AP-1-mediated senescence

  Giovanni Pietrogrande, et al., bioRxiv - Neuroscience 2023

  Quote: ... CHIR99021 3 μM (4423, Tocris), holo-transferrin 10 μg/ml (T0665 Sigma) ...
• Electron microscopic analysis of the influence of iPSC-derived motor neurons on bioengineered human skeletal muscle tissues

  Christine T. Nguyen, et al., bioRxiv - Cell Biology 2023

  Quote: ... 3 μM CHIR99021 (Tocris 4423) and 200 μM ascorbic acid (Sigma-Aldrich ...
• Tissue-intrinsic Wnt signals antagonize Nodal-driven AVE differentiation

  Sina Schumacher, et al., bioRxiv - Developmental Biology 2023

  Quote: ... and 3 µM CHIR99021 (Tocris), referred to as 2i + LIF.33 N2B27 was prepared as a 1:1 mixture of DMEM/F12 and Neuropan Basal Medium (both from PAN Biotech) ...
• Ca²⁺-sensing receptor regulates neuronal excitability via Kv7 channel and G_i/o protein signalling

  Nontawat Chuinsiri, et al., bioRxiv - Physiology 2023

  Quote: ... 3 μM CHIR-99021 (Tocris), 200 μM L-ascorbic acid (Merck) ...
• A Spatiotemporal and Machine-Learning Platform Accelerates the Manufacturing of hPSC-derived Esophageal Mucosa

  Ying Yang, et al., bioRxiv - Developmental Biology 2023

  Quote: ... and 3 μM CHIR99021 (Tocris). In base control strategy #14 ...
• Intestine-on-chip enhances nutrient and drug metabolism and maturation of iPSC-derived intestinal epithelial cells relative to organoids and Transwells

  Renée Moerkens, et al., bioRxiv - Cell Biology 2024

  Quote: ... CHIR99021 (3 μM, Tocris, #4423) and defined FBS (2% vol/vol ...
• Modulation of sweet preference by neurosteroid-sensitive, δ-GABA_A receptors in adult mouse gustatory insular cortex

  Priscilla E Yevoo, et al., bioRxiv - Neuroscience 2024

  Quote: ... 3 QX-314 (Tocris Bioscience), 0.2% biocytin (reversal potential (Vrev)[Cations] = 10mV) ...
• Differential inhibition of GABA release from mouse hippocampal interneuron subtypes by the volatile anesthetic isoflurane

  Iris A. Speigel, Hugh C. Hemmings Jr, bioRxiv - Neuroscience 2020

  Quote: ... containing 10 μM 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and 50 μM D,L-2-amino-5-phosphonovaleric acid (AP5) to block glutamatergic signaling (both from Tocris, Bristol, UK). Experiments involving tetrodotoxin (TTX ...
• Spatiotemporal control of microtubule acetylation by mechanical cues regulates lysosome dynamics at the immune synapse of B cells to promote antigen presentation

  Felipe Del Valle Batalla, et al., bioRxiv - Cell Biology 2023

  Quote: ... cells were treated with 1 uM of the microtubule-stabilizing agent SAHA (TOCRIS bioscience Cat. No. 149647-78-9) for 30 minutes before activation or experimental procedures ...
• Serotonergic drugs inhibit CHIKV infection at different stages of the cell entry pathway

  Ellen M. Bouma, et al., bioRxiv - Microbiology 2020

  Quote: ... 5-nonyloxytryptamine oxalate (5-NT) (Tocris, Bristol, United Kingdom) was diluted to a 5mM stock concentration in DMSO (Merck) ...
• cAMP−EPAC−PKCε−RIM1α signaling regulates presynaptic long-term potentiation and motor learning

  Xin-Tai Wang, et al., bioRxiv - Neuroscience 2022

  Quote: ... 8-pCPT (4853) and FR236924 (3091) were from Tocris (Bristol, UK). Dulbecco’s modified Eagle’s medium (DMEM ...
• CRISPRa-mediated disentanglement of the Dux-MERVL axis in the 2C-like state, totipotency and cell death

  Paul Chammas, et al., bioRxiv - Developmental Biology 2024

  Quote: ... culture media was changed and 8 µg/mL polybrene (7711, Tocris) was added to the media prior to the addition of 15 µl of concentrated virus ...
• AMPA receptor anchoring at CA1 synapses is determined by an interplay of N-terminal domain and TARP γ8 interactions

  Jake F. Watson, et al., bioRxiv - Neuroscience 2020

  Quote: ... 2 μM 2-chloroadenosine (Tocris Cat#3136) was added to aCSF to dampen epileptiform activity ...
• Facilitating mGluR4 activity reverses the long-term deleterious consequences of chronic morphine exposure

  Jerome AJ Becker, et al., bioRxiv - Neuroscience 2020

  Quote: ... They were left drug-free for 3 weeks before chronic daily treatment with vehicle (NaCl 0.9%) or VU0155041 (Tocris, Bristol, UK; 2.5 or 5 mg/kg, i.p.) started ...
• Predicting the activation of the androgen receptor by mixtures of ligands using Generalized Concentration Addition

  Jennifer J Schlezinger, et al., bioRxiv - Pharmacology and Toxicology 2020

  Quote: ... Cat. # 5274, purity ≥ 98%) and TFM-4AS-1 (CAS # 188589-61-9, Cat. # 3813, purity ≥ 98%) were purchased from Tocris Bioscience (Bristol ...
• Epilepsy-associated increase in gonadotropin-releasing hormone neuron firing in diestrous female mice is independent of chronic seizure burden severity

  Jiang Li, Catherine A. Christian-Hinman, bioRxiv - Neuroscience 2022

  Quote: ... females with regular estrous cycles underwent intrahippocampal injection of either KA (Tocris; 50 nl of 20 mM, n = 9 mice) or control sterile 0.9% saline (n = 6 mice ...
• The kallikrein-kinin system is falling into pieces: bradykinin fragments are biological active peptides

  Igor Maciel Souza-Silva, et al., bioRxiv - Pharmacology and Toxicology 2020

  Quote: ... Kinin receptors involvement in NO production by the tested peptides was assessed by selective antagonism of B1 and B2 receptors with Lys-(des-Arg9-Leu8-BK-(1-9) (B1RB) and HOE-140 (Tocris) (B2RB) ...
• Single cell RNA sequencing in isogenic FUS and TARDBP mutant ALS lines reveals early mitochondrial dysfunction as a common pathway in motor neurons

  Christoph Schweingruber, et al., bioRxiv - Neuroscience 2023

  Quote: ... one day of medium d10 (Medium d3–9 with 200 µM ascorbic acid [Sigma-Aldrich, A4403], 125 µM db-cAMP [Tocris, 1141], 2.5 µM DAPT [Tocris, 2634] ...
• A fluorescent sensor for spatiotemporally resolved endocannabinoid dynamics in vitro and in vivo

  Ao Dong, et al., bioRxiv - Neuroscience 2020

  Quote: ... 5-HT (Tocris), His (Tocris) ...
• Augmentation of extracellular ATP synergizes with chemotherapy in triple negative breast cancer

  Jasmine M Manouchehri, et al., bioRxiv - Cancer Biology 2022

  Quote: ... 5-BDBD (Tocris), ENPP1 inhibitor C (Cayman Chemical ...
• A toolkit of highly selective and sensitive genetically encoded neuropeptide sensors

  Huan Wang, et al., bioRxiv - Neuroscience 2022

  Quote: ... 5 Desmopressin (Tocris), 1 NTS ...
• New and improved GRAB fluorescent sensors for monitoring dopaminergic activity in vivo

  Fangmiao Sun, et al., bioRxiv - Neuroscience 2020

  Quote: ... 5-HT (Tocris), histamine (Tocris) ...
• An ultrasensitive GRAB sensor for detecting extracellular ATP in vitro and in vivo

  Zhaofa Wu, et al., bioRxiv - Neuroscience 2021

  Quote: ... 5-HT (Tocris), HA (Tocris) ...
• Improved dual-color GRAB sensors for monitoring dopaminergic activity in vivo

  Yizhou Zhuo, et al., bioRxiv - Neuroscience 2023

  Quote: ... 5-HT (Tocris), HA (Tocris) ...
• The role of heparan sulfate in enhancing the chemotherapeutic response in triple-negative breast cancer

  Jasmine M Manouchehri, et al., bioRxiv - Cancer Biology 2023

  Quote: ... 5-BDBD (Tocris) and heparan sodium sulfate (Sigma).
• Sex-specific Effects of the Endocannabinoid Agonist 2-Arachidonoylglycerol on Sleep and Circadian Disruptions during Fentanyl Withdrawal

  Mackenzie C. Gamble, et al., bioRxiv - Neuroscience 2023

  Quote: ... 2-Arachidonoylglycerol (2-AG) was obtained from Tocris Biosciences (Cat ...
• Dopaminergic regulation of vestibulo-cerebellar circuits through unipolar brush cells

  Jose Ernesto Canton-Josh, et al., bioRxiv - Neuroscience 2022

  Quote: ... 1 μM Pyr-3 (Tocris,3753), 1 mM MNI-caged-L-glutamate ...
• Single-cell profiling of transcriptome and histone modifications with EpiDamID

  Franka J. Rang, et al., bioRxiv - Genomics 2021

  Quote: ... 3 μM CHIR99021 (Tocris, SML1046-5MG), 1000 U/mL ESGRO mLIF ...
• Proteomic Analysis of Huntington’s Disease Medium Spiny Neurons Identifies Alterations in Lipid Droplets

  Kizito-Tshitoko Tshilenge, et al., bioRxiv - Neuroscience 2022

  Quote: ... GABA (3 mM, Tocris Bioscience, 0344), CaCl2 (1.8 mM ...
• Identification of the main barriers to Ku accumulation in chromatin

  Madeleine Bossaert, et al., bioRxiv - Molecular Biology 2024

  Quote: ... or NU-7441 (3 µM, Tocris) were added when specified 1 h prior to irradiation ...
• Defective Schwann cell lipid metabolism alters plasma membrane dynamics in Charcot-Marie-Tooth disease 1A

  Robert Prior, et al., bioRxiv - Neuroscience 2023

  Quote: ... 3 mM CHIR-99021 (Tocris Biosciences), and 20 µM SB 431542 (Tocris Biosciences) ...
• 3D genome organization around nuclear speckles drives mRNA splicing efficiency

  Prashant Bhat, et al., bioRxiv - Molecular Biology 2023

  Quote: ... 3 μM CHIR 99021 (Tocris, 4423), and 50 nM PI 103 (Tocris ...
• Recording morphogen signals reveals origins of gastruloid symmetry breaking

  Harold M. McNamara, et al., bioRxiv - Developmental Biology 2023

  Quote: ... and 3 μM CHIR99021 (Tocris, 4423).
• Rapamycin mitigates Valproic Acid-induced teratogenicity in human and animal models by suppressing AP-1-mediated senescence

  Giovanni Pietrogrande, et al., bioRxiv - Neuroscience 2023

  Quote: ... and CHIR99021 3 μM (4423, Tocris). After 3 days ...
• Control of gastruloid patterning and morphogenesis by the Erk and Akt signaling pathways

  Evan J. Underhill, Jared E. Toettcher, bioRxiv - Developmental Biology 2023

  Quote: ... and 3 μM CHIR99021 (Tocris, 4423).
• Elevated ENO2 Disrupts VSMCs Homeostasis Facilitating the Development of Aortic Dissection

  Weixing Cai, et al., bioRxiv - Molecular Biology 2023

  Quote: ... Ang II (4474-91-3, Tocris) was injected subcutaneously at a total dose of 1 ...
• Regulation of hippocampal mossy fiber-CA3 synapse function by a Bcl11b/C1ql2/Nrxn3(25b+) pathway

  Artemis Koumoundourou, et al., bioRxiv - Neuroscience 2023

  Quote: ... 3 μM DCG-IV (Tocris Bioscience) was applied after each experiment ...
• Human neuron subtype programming through combinatorial patterning with scRNA-seq readouts

  Hsiu-Chuan Lin, et al., bioRxiv - Bioengineering 2023

  Quote: ... and 3 µM CHIR99021 (Tocris Bioscience).
• Engineering fluorescent reporters in human pluripotent cells and strategies for live imaging human neurogenesis

  Alwyn Dady, et al., bioRxiv - Developmental Biology 2024

  Quote: ... supplemented with 3 µM Chiron99021 (Tocris) and 20 ng/ml bFGF (PeproTech ...
• GluN2B-mediated regulation of silent synapses for receptor specification and addiction memory

  Hyun Jin Kim, et al., bioRxiv - Neuroscience 2024

  Quote: ... Ifenprodil hemitartrate (3 μM, #0545, Tocris) and PPDA (0.1 μM ...
• Excitatory Cortical Neurons from CDKL5 Deficiency Disorder Patient-Derived Organoids Show Early Hyperexcitability Not Identified in Neurogenin2 Induced Neurons

  Madison R. Glass, et al., bioRxiv - Neuroscience 2024

  Quote: ... 3 μM CHIR99021 (Tocris Bioscience # 4423) and the MEK inhibitor ...
• Modelling oxaliplatin resistance in colorectal cancer reveals a SERPINE1-based gene signature (RESIST-M) and therapeutic strategies for pro-metastatic CMS4 subtype

  Stephen Qi Rong Wong, et al., bioRxiv - Cancer Biology 2024

  Quote: Oxaliplatin (CAS#: 61825-94-3, Tocris) was dissolved in DMSO ...
• The transcription factor GABPA is a master regulator of naïve pluripotency

  Chengjie Zhou, Meng Wang, Chunxia Zhang, Yi Zhang, bioRxiv - Developmental Biology 2024

  Quote: ... and 3 μM CHIR99021 (Tocris, 4423).
• B cell receptor induced IL-10 production from neonatal CD19+CD43- cells depends on STAT5 mediated IL-6 secretion

  Jiro Sakai, et al., bioRxiv - Immunology 2022

  Quote: ... cells were treated with Pyridone 6 (Tocris Bioscience, Minneapolis, MN), Pimozide (Tocris Bioscience) ...