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501 - 550 of 1830 citations for 1 Benzyl 4 5 benzyloxy 6 methoxy 1 indanone 2 ylidenyl methylpiperidine since 2020

• Synapse-specific diversity of distinct postsynaptic GluN2 subtypes defines transmission strength in spinal lamina I

  Graham. M. Pitcher, et al., bioRxiv - Neuroscience 2023

  Quote: ... The following compounds were added to raCSF as indicated in the Results section: D-(-)-2-Amino-5-phosphonopentanoic acid (D-APV, 100 μM dissolved in H2O; Tocris Bioscience), (5S,10R)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d] cyclohepten-5,10-imine maleate (MK-801 ...
• uPTI: uniaxial permittivity tensor imaging of intrinsic density and anisotropy

  Li-Hao Yeh, et al., bioRxiv - Biophysics 2021

  Quote: ... Cells were treated with 6 μM CHIR99021 (Tocris) for 48 hours on day 0 ...
• Metabolic regulation of species-specific developmental rates

  Margarete Diaz-Cuadros, et al., bioRxiv - Developmental Biology 2021

  Quote: ... 6 μM Chir 99021 (Tocris cat. no. 4423), 20ng/ml murine bFGF (PeproTech cat ...
• Extracellular matrix supports excitation-inhibition balance in neuronal networks by stabilizing inhibitory synapses

  Egor Dzyubenko, et al., bioRxiv - Neuroscience 2020

  Quote: ... GABAA (6 µM bicuculline metiodide, Tocris, Bristol, UK) or GABAB (100 µM CGP46381 ...
• Fibrillar α-synuclein induces neurotoxic astrocyte activation via RIP kinase signaling and NF-κB

  Tsui-Wen Chou, et al., bioRxiv - Neuroscience 2020

  Quote: ... and Pyridone 6 (#6577) were purchased from Tocris Bioscience (Bristol ...
• Chronic BDNF simultaneously inhibits and unmasks superficial dorsal horn neuronal activity

  Sascha R.A. Alles, et al., bioRxiv - Neuroscience 2020

  Quote: ... 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX, Tocris), 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo[f]quinoxaline-2,3-dione (NBQX ...
• Hepatic NFAT signaling regulates the expression of inflammatory cytokines in cholestasis

  Shi-Ying Cai, et al., bioRxiv - Molecular Biology 2020

  Quote: ... KN-62 and Inca-6 were from Tocris Bioscience (Minneapolis ...
• Gypenosides modulate NCX calcium flux, insulin secretion and cytoprotection in BRIN-BD11 pancreatic β-cells

  Chinmai Patibandla, et al., bioRxiv - Pharmacology and Toxicology 2021

  Quote: ... and SN-6 (2184) were purchased from Tocris, UK ...
• Functional analysis of a common BAG3 allele associated with protection from heart failure

  Juan A Perez-Bermejo, et al., bioRxiv - Genetics 2021

  Quote: ... containing 6 μM or 12 μM CHIR99021 (Tocris) for 24 or 48 hours ...
• Mechanisms Controlling Hemolymph Circulation Under Resting Conditions In The Chagas Disease Vector Rhodnius Prolixus (Stål)

  María José Villalobos Sambucaro, et al., bioRxiv - Physiology 2023

  Quote: Xestospongin-C (Xe-C) -6 µM-(Tocris Bioscience). A membrane-permeably compound isolated from the sponge Xestospongia sp. ...
• Multiomics-based assessment of 2D and 3D human iPSC-cardiomyocyte models of insulin resistance demonstrate metabolic and contractile dysfunction that recapitulates diabetic cardiomyopathy

  Ryan D. Carter, et al., bioRxiv - Molecular Biology 2024

  Quote: ... and the GSK3 inhibitor CHIR99021 (Tocris, 6 µM) for days zero and one ...
• Obesity medication lorcaserin requires brainstem GLP-1 neurons to reduce food intake in mice

  Stefan Wagner, et al., bioRxiv - Neuroscience 2022

  Quote: ... Exendin-4 (Tocris) was administered at 0.004 to 0.04 mg/kg ...
• Astrocytic Ca²⁺ signals partake in inhibitory neurovascular coupling in a brain state-dependent manner

  Aske Krogsgaard, et al., bioRxiv - Neuroscience 2022

  Quote: ... DSP-4 (Tocris) was dissolved in saline and a single dose (75 mg/kg BW ...
• Localised Astrocyte Ca2+ Activity Regulates Neurovascular Coupling Responses to Active Sensing

  Jakob Akbar Stelzner, et al., bioRxiv - Neuroscience 2024

  Quote: DSP-4 (Tocris) was dissolved in saline ...
• Differential inhibition of GABA release from mouse hippocampal interneuron subtypes by the volatile anesthetic isoflurane

  Iris A. Speigel, Hugh C. Hemmings Jr, bioRxiv - Neuroscience 2020

  Quote: ... containing 10 μM 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and 50 μM D,L-2-amino-5-phosphonovaleric acid (AP5) to block glutamatergic signaling (both from Tocris, Bristol, UK). Experiments involving tetrodotoxin (TTX ...
• Serotonergic drugs inhibit CHIKV infection at different stages of the cell entry pathway

  Ellen M. Bouma, et al., bioRxiv - Microbiology 2020

  Quote: ... 5-nonyloxytryptamine oxalate (5-NT) (Tocris, Bristol, United Kingdom) was diluted to a 5mM stock concentration in DMSO (Merck) ...
• Amyloid-beta mediates homeostatic synaptic plasticity

  Christos Galanis, et al., bioRxiv - Neuroscience 2020

  Quote: ... Begacestat (1 μM; Tocris, Cat# 4283), KN-92 (5 μM ...
• A Self-Limiting Circuit Regulates Mammary Cap Cell Plasticity Through TGF-beta Signaling

  Armelle Le Guelte, Ian G. Macara, bioRxiv - Developmental Biology 2021

  Quote: ... BMP inhibitor (LDN193189, 1 μM, Tocris), JNK inhibitor (JNK-IN-8 ...
• Dopaminergic regulation of vestibulo-cerebellar circuits through unipolar brush cells

  Jose Ernesto Canton-Josh, et al., bioRxiv - Neuroscience 2022

  Quote: ... 1 μM Pyr-3 (Tocris,3753), 1 mM MNI-caged-L-glutamate ...
• Multiscale activity imaging in mammary gland reveals how oxytocin enables lactation

  Alexander J. Stevenson, et al., bioRxiv - Cell Biology 2020

  Quote: ... calphostin C (Tocris, 1626, 1 μM), dantrolene (Tocris ...
• Human cerebral tissues created via active cellular reaggregation produce functionally interconnected 3D neuronal network to mimic pathological circuit disturbance

  Aref Saberi, et al., bioRxiv - Bioengineering 2020

  Quote: ... 1 μM Dorsomorphin dihydrochloride (Tocris, 3093), 10 μM SB431542 (Tocris ...
• Calsyntenin-3, an atypical cadherin, suppresses inhibitory basket- and stellate-cell synapses but boosts excitatory parallel-fiber synapses in cerebellum

  Zhihui Liu, et al., bioRxiv - Neuroscience 2021

  Quote: ... (1) 10 μM CNQX (1045, Tocris) and 10 μM APV were included in ACSF ...
• Nogo-A Beyond the RhoA/ROCK Pathway – Novel Components of Intracellular Nogo-A Signaling Cascades

  Martina A. Maibach, et al., bioRxiv - Neuroscience 2020

  Quote: ... 1 nM JTE-013 (Tocris, 2392), 0.5 U Heparinase III (Sigma ...
• Dopaminergic neuromodulation of spike timing dependent plasticity in mature adult rodent and human cortical neurons

  Emma Louise Louth, et al., bioRxiv - Neuroscience 2020

  Quote: ... 1 μM gabazine (SR 95531, Tocris) was applied at the end of an STDP recordings ...
• Developmental Divergence of Sensory Stimulus Representation in Cortical Interneurons

  Rahel Kastli, et al., bioRxiv - Neuroscience 2020

  Quote: ... 1 µM TTX (Tetrodotoxin citrate, Tocris) was added to the circulating aCSF and 12 min after ...
• Delta Oscillations Are a Robust Biomarker of Dopamine Depletion Severity and Motor Dysfunction in Awake Mice

  Timothy C. Whalen, et al., bioRxiv - Neuroscience 2020

  Quote: ... 1 mg/kg SKF81297 (Tocris Biosciences), or 3 mg/kg quinpirole ...
• Functional brain region-specific neural spheroids for modeling neurological diseases and therapeutics screening

  Caroline E. Strong, et al., bioRxiv - Bioengineering 2022

  Quote: ... 1 mM cAMP (Tocris, cat# 1141), and 20 nM ascorbic acid (Tocris ...
• Cellular Mechanisms Underlying Central Sensitization in a Mouse Model of Chronic Muscle Pain

  Yu-Ling Lin, et al., bioRxiv - Neuroscience 2022

  Quote: ... and tetrodotoxin (TTX; 1 µM, Tocris) to block GABAA-receptor- ...
• Cross-activation of the FGF, TGF-β and WNT pathways constrains BMP4-mediated induction of the Totipotent state in mouse embryonic stem cells

  Thulaj Meharwade, et al., bioRxiv - Developmental Biology 2022

  Quote: ... TAK1 inhibitor (1 μM, Tocris 3604), SB431542 (2 μM ...
• Augmentation of extracellular ATP synergizes with chemotherapy in triple negative breast cancer

  Jasmine M Manouchehri, et al., bioRxiv - Cancer Biology 2022

  Quote: ... sodium polyoxotungstate or POM-1 (Tocris), PSB 069 (Tocris) ...
• Interferon-γ signaling synergizes with LRRK2 in human neurons and microglia

  Silvia De Cicco, et al., bioRxiv - Neuroscience 2020

  Quote: ... LRRK2-IN-1 and GSK2578215A (Tocris).
• Somatostatin receptor subtypes 1 and 4 redundantly regulate neprilysin, the major amyloid-beta degrading enzyme in brain

  Per Nilsson, et al., bioRxiv - Neuroscience 2020

  Quote: ... 1 μM cyclo-SST (Tocris #3493), 100 nM CH275 (Tocris #2454) ...
• Purinergic signaling controls spontaneous activity in the auditory system throughout early development

  Travis A. Babola, et al., bioRxiv - Neuroscience 2020

  Quote: ... or MRS2500 (1 µM; Tocris, 2154) were added directly to the bath and allowed to equilibrate for 5 minutes before capturing an additional 5-minutes used for analysis of pharmacological block.
• Autologous humanized mouse models of iPSC-derived tumors allow for the evaluation and modulation of cancer-immune cell interactions

  Gaël Moquin-Beaudry, et al., bioRxiv - Cancer Biology 2021

  Quote: ... and 1 μM A83-01 (Tocris). From day 10 to day 15 ...
• Preservation of prehearing spontaneous activity enables early auditory system development in deaf mice

  Calvin J. Kersbergen, et al., bioRxiv - Neuroscience 2022

  Quote: ... Application of MRS2500 (Tocris, 1 μM) was performed by superfusion by gravity of MRS2500-containing aCSF without interruption of continuous aCSF flow ...
• High Mobility Group Box 1 enhances ADP-mediated platelet activation by increasing platelet surface P2Y₁₂ localization

  Deirdre Nolfi-Donegan, et al., bioRxiv - Cell Biology 2021

  Quote: ... P2Y1 (MRS 2500, 1 nM; Tocris); P2Y12 (AR-C 66096 ...
• New and improved GRAB fluorescent sensors for monitoring dopaminergic activity in vivo

  Fangmiao Sun, et al., bioRxiv - Neuroscience 2020

  Quote: ... and/or 1 μM Halo (Tocris), SCH-23390 (Tocris) ...
• Reconstructing human early embryogenesis in vitro with pluripotent stem cells

  Berna Sozen, et al., bioRxiv - Developmental Biology 2021

  Quote: ... (S)-(+)-Dimethindenemaleate (D, 1 mM; Tocris, 1425) and Minocycline hydrochloride (M ...
• Prednisolone rescues Duchenne Muscular Dystrophy phenotypes in human pluripotent stem cells-derived skeletal muscle in vitro

  Ziad Al Tanoury, et al., bioRxiv - Cell Biology 2020

  Quote: ... 1 μM Chiron (Tocris, Cat. # 4423), 0.2% Pen/Strep (Life Technologies ...
• The proteasomal deubiquitinating enzyme PSMD14 regulates macroautophagy by controlling Golgi-to-ER retrograde transport

  HA Bustamante, et al., bioRxiv - Cell Biology 2020

  Quote: ... Torin-1 was purchased from Tocris Bioscience (Bristol ...
• Prednisolone rescues Duchenne Muscular Dystrophy phenotypes in human pluripotent stem cells-derived skeletal muscle in vitro

  Ziad Al Tanoury, et al., bioRxiv - Cell Biology 2020

  Quote: ... 1 μM Chiron (Tocris, Cat. # 4423), 0.2% Pen/Strep (Life Technologies ...
• High-Throughput Human Primary Cell-Based Airway Model for Evaluating Influenza, Coronavirus, or other Respiratory Viruses in vitro

  A.L. Gard, et al., bioRxiv - Microbiology 2020

  Quote: ... 1 μM A-83-01 (Tocris), 0.2 μM DMH-1 (Tocris) ...
• Leveraging complex interactions between signaling pathways involved in liver development to robustly improve the maturity and yield of pluripotent stem cell-derived hepatocytes

  Claudia Raggi, et al., bioRxiv - Developmental Biology 2020

  Quote: ... and 1 μM A83-01 (Tocris) for 5 days ...
• Neuroblastoma-associated chromosomal aberrations drive cell identity loss in human neural crest via disruption of developmental regulators

  Ingrid M. Saldana-Guerrero, et al., bioRxiv - Cancer Biology 2022

  Quote: ... CHIR99021 (1 μM, Cat# 4423, Tocris), BMP4 (15ng/ml ...
• Cohesin-mediated DNA loop extrusion resolves sister chromatids in G2 phase

  Paul Batty, et al., bioRxiv - Cell Biology 2023

  Quote: ... 1 µM dTAG-7 (Tocris, 6912) was added 14 h after the release from the final aphidicolin block ...
• Gravitational and mechanical forces drive mitochondrial translation through the cell adhesion–FAK axis

  Taisei Wakigawa, et al., bioRxiv - Molecular Biology 2023

  Quote: ... BAY-293 (Tocris, 6857, 1 μM), LY294002 (Sigma‒Aldrich ...
• Circular RNA circPLOD2 regulates pericyte function by targeting the transcription factor KLF4

  Simone Franziska Glaser, et al., bioRxiv - Molecular Biology 2022

  Quote: ... and HOECHST (1:500; #5117, Tocris) in blocking buffer at 4 °C ...
• PKC modulator bryostatin-1 therapeutically targets CNS innate immunity to attenuate neuroinflammation and promote remyelination

  Payam Gharibani, et al., bioRxiv - Neuroscience 2023

  Quote: Bryo-1 was purchased from Tocris Bioscience (catalog no ...
• Neuronal FOS reports synchronized activity of presynaptic neurons

  Margarita Anisimova, et al., bioRxiv - Neuroscience 2023

  Quote: ... or L-CCG-1 (Tocris, 0333) at 10 or 500 µM ...
• LRRK2 Suppresses Lysosome Degradative Activity in Macrophages and Microglia Through MiT-TFE Transcription Factor Inhibition

  Narayana Yadavalli, Shawn M. Ferguson, bioRxiv - Cell Biology 2023

  Quote: ... LRRK2-IN-1 (Tocris Bioscience # 4273), EDTA (Invitrogen#15575-038).