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151 - 200 of 10000+ citations for 4 2 Hydroxyimino 2 4 methoxy phenyl ethyl piperazine 1 carboxylic acid tert butyl ester since 2020

• Cross-species analysis of LZTR1 loss-of-function mutants demonstrates dependency to RIT1 orthologs

  Antonio Cuevas-Navarro, et al., bioRxiv - Genetics 2022

  Quote: ... ERK1/2 (Cell Signaling Technologies, Cat #4696; 1:2000), p-MEK (Cell Signaling Technologies ...
• Optimized transcriptional signature for evaluation of MEK/ERK pathway baseline activity and long-term modulations in ovarian cancer

  Mikhail S. Chesnokov, Anil Yadav, Ilana Chefetz, bioRxiv - Cancer Biology 2022

  Quote: ... total ERK1/2 (Cell Signaling Technology, 137F5, 1:1000), pp90RSK1 (R&D Systems ...
• IFT20 is critical for early chondrogenesis during endochondral ossification

  Hiroyuki Yamaguchi, et al., bioRxiv - Developmental Biology 2021

  Quote: ... anti-ERK1/2 (Cell Signaling technology; #4695, 1:1,000), anti-active β-Catenin (Cell signaling technology ...
• Nicotinamide mononucleotide treatment increases NAD+ levels in an iPSC Model of Parkinson’s Disease

  Brett K. Fulleylove-Krause, et al., bioRxiv - Neuroscience 2020

  Quote: ... rabbit anti-SIRT 2 (Cell Signaling, 12672, 1:1000), rabbit anti-SIRT 3 (Abgent ...
• Presenilin-deficient neurons and astrocytes display normal mitochondrial phenotypes

  Sabrina Contino, et al., bioRxiv - Neuroscience 2020

  Quote: ... Anti-Presenilin 2 (1:1,000; Cell Signaling, Danvers, USA); Anti-Tubulin (1:3000 ...
• Biliverdin reductase bridges focal adhesion kinase to Src to modulate synaptic signaling

  Chirag Vasavda, et al., bioRxiv - Neuroscience 2021

  Quote: ... rabbit anti-ERK1/2 (Cell Signaling 4695, 1:2000), rabbit anti-phospho-PAK1 (S199/S204 ...
• Exploiting KRAS-driven Ferroaddiction in Cancer Through Ferrous Iron-Activatable Drug Conjugates (FeADC)

  Honglin Jiang, et al., bioRxiv - Cancer Biology 2021

  Quote: ... Erk1/2 (Cell Signaling Technology, 4696, Dilution: 1:1000); GAPDH (Cell Signaling Technology ...
• Adipocytes reprogram glucose metabolism in cancer cells promoting metastasis

  Abir Mukherjee, et al., bioRxiv - Cancer Biology 2022

  Quote: ... HK-2 (Cell Signaling Technology, cat# 2867, 1:1000), p-STAT3 Tyr 708 (Cell Signaling Technology ...
• Acquired and intrinsic resistance to vemurafenib in BRAF^V600E-driven melanoma brain metastases

  Ping Zhang, et al., bioRxiv - Pharmacology and Toxicology 2022

  Quote: ... phospho-ERK1/2 (1:200; 4370; Cell Signaling Technology), phospho-AKT (1:8,000 ...
• PDGFRα/β heterodimer activation negatively affects downstream ERK1/2 signaling and cellular proliferation

  Maria B. Campaña, et al., bioRxiv - Cell Biology 2023

  Quote: ... ERK1/2 (1:1000; 9102; Cell Signaling Technology, Inc.); phospho-AKT (Ser473 ...
• Rewiring of the TCR signalosome in natural intestinal Intraepithelial T lymphocytes drives non-deletional tolerance

  Harriet J. Watt, et al., bioRxiv - Immunology 2023

  Quote: ... SHP-1 or SHP-2 (all Cell Signaling Technology) followed by anti-rabbit Dylight649 (1:500 ...
• Competitive, connective and allosteric Nanobodies that modulate the SOS1•RAS protein-protein interactions and tune the nucleotide exchange rate as a starting point for drug design

  Baptiste Fischer, et al., bioRxiv - Bioengineering 2023

  Quote: ... rabbit monoclonal ERK1/2 (1:50, Cell Signaling #4696), and mouse monoclonal Flag antibody (clone M2 ...
• Peripheral extracellular vesicle-derived miR-150-3p exacerbates acute kidney injury following acute pancreatitis by promoting ferroptosis through FTH1 signaling

  Ji-tao Cui, et al., bioRxiv - Cell Biology 2023

  Quote: ... anti-Cox-2 (1:1,000, 9461, Cell Signaling Technology), anti-β-actin (1:2,000 ...
• Phencyclidine disrupts neural coordination and cognitive control by dysregulating translation

  Eun Hye Park, et al., bioRxiv - Neuroscience 2023

  Quote: ... ERK1/2 (Cell Signaling Technology, Cat.No.9102S, 1:1000), phospho-4EBP1 (Cell Signaling Technology ...
• Bcl-xL is translocated to the nucleus via CtBP2 to epigenetically promote metastasis

  Tiantian Zhang, et al., bioRxiv - Cancer Biology 2023

  Quote: ... Mek1/2 (1:1,000, Cell Signaling Technology, Cat# 9122), alpha-tubulin (Sigma ...
• Neural stem cells protect blood-brain barrier integrity via the p38, JNK, and ERK1/2 pathways following intracerebral hemorrhage in rats

  Jing Sun, et al., bioRxiv - Neuroscience 2023

  Quote: ... anti-ERK1/2 (Cell Signaling, USA, 1:1000 dilution), anti-p38 (Cell Signaling ...
• Host-derived oxidized phospholipids initiate effector-triggered immunity fostering lethality upon microbial encounter

  Marco Di Gioia, et al., bioRxiv - Immunology 2023

  Quote: ... ERK1/2 (1:1000, Cell Signaling Technology, Cat# 9102), phospho-p38 (Thr180/Tyr182 ...
• Multifunctional molecular hybrid for targeted colorectal cancer cells: Integrating doxorubicin, AS1411 aptamer, and T9/U4 ASO

  Kanpitcha Jiramitmongkon, et al., bioRxiv - Molecular Biology 2024

  Quote: ... Bcl–2 (1:1000; 25 – 28 kDa, Cell signaling), and Bax (1:1000 ...
• Reorganization of innate immune cell lipid profiles by bioinspired meroterpenoids to limit inflammation

  Lorenz Waltl, et al., bioRxiv - Pharmacology and Toxicology 2024

  Quote: ... rabbit anti-MEK1/2 (1:1000; # 9122; Cell Signaling), rabbit anti-phospho-MEK1/2 (1:1000 ...
• Ezrin defines TSC1 activation at endosomal compartments through EGFR-AKT signaling

  Giuliana Giamundo, et al., bioRxiv - Cell Biology 2024

  Quote: ... rabbit anti-MAPKAPK-2 (1:1000, Cell Signaling 3042), rabbit anti-phospho-MAPKAPK-2 (Thr222 ...
• Miro1 expression alters global gene expression, ERK1/2 phosphorylation, oxidation, and cell cycle progression

  Nathaniel Shannon, et al., bioRxiv - Cell Biology 2024

  Quote: ... total MEK1/2 (1:1000, Cell Signaling Technology #9122), Cofilin (1:1000 ...
• The pro-apoptotic effect of chronic contractile activity-induced extracellular vesicles on Lewis Lung Carcinoma cells

  Patience O. Obi, et al., bioRxiv - Cancer Biology 2024

  Quote: ... rabbit anti-Bcl-2 (3498, Cell Signaling, 1:1000), rabbit anti-Bax (2772 ...
• XPO1 inhibition modulates the Wnt/β-catenin signaling pathway to reduce colorectal cancer tumorigenesis

  Andrew E. Evans, et al., bioRxiv - Cancer Biology 2024

  Quote: ... anti-COX-2 (1/300; Cell Signaling, Cat# 12282S), anti-Ki67 (1/200 ...
• XPO1 inhibition modulates the Wnt/β-catenin signaling pathway to reduce colorectal cancer tumorigenesis

  Andrew E. Evans, et al., bioRxiv - Cancer Biology 2024

  Quote: ... anti-COX-2 (1/1000; Cell Signaling, Cat # 12282S), anti-Actin (1/5000 ...
• Human GBP1 promotes pathogen vacuole rupture and inflammasome activation during Legionella pneumophila infection

  Antonia R. Bass, Sunny Shin, bioRxiv - Microbiology 2020

  Quote: ... caspase-4 (4450S; Cell Signaling), caspase-5 (D3G4W ...
• Inositol depletion regulates phospholipid metabolism and activates stress signaling in HEK293T cells

  Mahmoud Suliman, et al., bioRxiv - Cell Biology 2022

  Quote: ... ATF-4 (#11815, Cell signaling), LC3B (#NB600-1384 ...
• Regulated Induced Proximity Targeting Chimeras (RIPTACs): a Novel Heterobifunctional Small Molecule Therapeutic Strategy for Killing Cancer Cells Selectively

  Kanak Raina, et al., bioRxiv - Cancer Biology 2023

  Quote: ... 4% formaldehyde (#12606P, Cell Signaling) was added to fix cells for 15 min at room temperature ...
• Generation of human blastocyst-like structures from pluripotent stem cells

  Yong Fan, et al., bioRxiv - Developmental Biology 2021

  Quote: ... rabbit anti-GATA6 (Cell Signaling Technology, 5851S, monoclonal, D61E4, 4, 1:1000), mouse anti-SOX2 (Abcam ...
• Extracellular vesicles adhere to cells predominantly through the interaction of CD151-associated integrin heterodimers and GM1 with laminin

  Tatsuki Isogai, et al., bioRxiv - Cell Biology 2024

  Quote: ... rabbit polyclonal anti-integrin beta 4 (1:500, Cell Signaling, Cat# 4707S), rabbit polyclonal anti-integrin beta 5 (1:500 ...
• Loss of H3K9 trimethylation leads to premature aging

  Calida Mrabti, et al., bioRxiv - Physiology 2024

  Quote: ... NEL105001EA).Antibodies: mouse OCT-3/4 (C-10) (1:3000, Cell Signaling, 13969); mouse β-Actin (AC-74 ...
• A Sequence determinant in 3’UTR of mRNAs for Nuclear Retention by Paraspeckles

  Audrey Jacq, et al., bioRxiv - Molecular Biology 2020

  Quote: ... (MEK1/2) (anti-MEK1/2, Cell Signaling, Leiden, The Netherlands) on the other hand.
• NF1 regulates mesenchymal glioblastoma plasticity and aggressiveness through the AP-1 transcription factor FOSL1

  Carolina Marques, et al., bioRxiv - Cancer Biology 2020

  Quote: ... ERK1/2 (Cell Signaling Technology, #9102, 1:1000; Abcam #ab17942, 1:1000), p-MEK (S217/221 ...
• Unique vulnerability of RAC1-mutant melanoma to combined inhibition of CDK9 and immune checkpoints

  Alexa C. Cannon, et al., bioRxiv - Cancer Biology 2023

  Quote: ... PAK 1/2/3 1:1000 (Cell Signaling Technology Cat# 2604, RRID:AB_2160225), Myc-Tag 1:1000 (Cell Signaling Technology Cat# 2276 ...
• Regulation of early growth response-1 (Egr-1) gene expression by Stat1-independent type I interferon signaling and respiratory viruses

  Chilakamarti V. Ramana, bioRxiv - Genomics 2020

  Quote: ... and subjected to immunoblotting with the antibodies for phosphorylated Erk-1/2 (Thr202/Tyr 204) or total Erk-1/2 from Cell Signaling Technology (Beverly, MA). Blots were visualized by enhanced chemiluminescence western detection system (Pierce ...
• Glutamine deficiency in solid tumors confers resistance to ribosomal RNA synthesis inhibitors

  Melvin Pan, et al., bioRxiv - Cancer Biology 2021

  Quote: ... phospho-ERK1/2 (Thr202/Tyr204) (1:500 Cell Signaling Technology), ERK1/2 (Thr202/Tyr204 ...
• Glutamine deficiency in solid tumors confers resistance to ribosomal RNA synthesis inhibitors

  Melvin Pan, et al., bioRxiv - Cancer Biology 2021

  Quote: ... phospho-MEK1/2 (Ser217/221) (1:500 Cell Signaling Technology), MEK1/2 (1:500 Cell Signaling Technology) ...
• HDAC and MAPK/ERK Inhibitors Cooperate to Reduce Viability and Stemness in Medulloblastoma

  Mariane da Cunha Jaeger, et al., bioRxiv - Cancer Biology 2020

  Quote: ... Phospho-p44/42 MAPK (pErk1/2, 1:2000; Cell Signaling), p44/42 MAPK (Erk1/2 ...
• FCHSD2 Controls Oncogenic ERK1/2 Signaling Outcome by Regulating Endocytic Trafficking

  Guan-Yu Xiao, Sandra L. Schmid, bioRxiv - Cell Biology 2020

  Quote: ... p-ERK1/2 T202/Y204 (#4370S, 1:1000, Cell Signaling), ERK1/2 (#4695S ...
• Extracellular Superoxide Dismutase (EC-SOD) Regulates Gene Methylation and Cardiac Fibrosis During Chronic Hypoxic Stress

  Ayan Rajgarhia, et al., bioRxiv - Developmental Biology 2020

  Quote: ... and ERK 1/2 (Cell Signaling Technology, Danvers, MA, USA)
• Wnt-dependent activation of ERK mediates repression of chondrocyte fate during calvarial development

  Beatriz Ibarra, Cody Machen, Radhika P. Atit, bioRxiv - Developmental Biology 2021

  Quote: ... rabbit anti-phospho-ERK1/2 (1:1250, Cell Signaling 4370). Wide-field images were captured at 20X and 40X using the Leica DMi8 inverted microscope using the Leica Application Suite X (LASX ...
• Neurofibromin 1 controls metabolic balance and Notch-dependent quiescence of juvenile myogenic progenitors

  Xiaoyan Wei, et al., bioRxiv - Cell Biology 2021

  Quote: ... Rabbit anti-pErk1/2 (Cell Signaling Technology # 9101; 1:1000), Rabbit anti-Erk1/2 (Cell Signaling Technology # 9102 ...
• Neurofibromin 1 controls metabolic balance and Notch-dependent quiescence of juvenile myogenic progenitors

  Xiaoyan Wei, et al., bioRxiv - Cell Biology 2021

  Quote: ... Rabbit anti-Erk1/2 (Cell Signaling Technology # 9102; 1:1000), Mouse anti-ß-Actin (Cell Signaling Technology # 58169 ...
• Neurofibromin 1 controls metabolic balance and Notch-dependent quiescence of juvenile myogenic progenitors

  Xiaoyan Wei, et al., bioRxiv - Cell Biology 2021

  Quote: ... Rabbit anti-pErk1/2 (Cell Signaling Technology # 9101; 1:300), Rabbit anti-phosphor (s235/236)-S6 (Cell Signaling Technology # 4858 ...
• The Peroxiredoxin 6 gene plays a critical role in the homeostatic regulation of fear response

  Sarayut Phasuk, et al., bioRxiv - Neuroscience 2020

  Quote: ... anti-total ERK1/2 (1:1000; Cell Signaling, Danvers, MA), anti-PSD95 (1:2000 ...
• The CoREST Repressor Complex Mediates Phenotype Switching and Therapy Resistance in Melanoma

  Muzhou Wu, et al., bioRxiv - Cancer Biology 2020

  Quote: ... p44/42 MAPK (Erk1/2) (Cell Signaling, 9102s, 1:1000), MITF (Cell Signaling ...
• Hemangiosarcoma cells induce M2 polarization and PD-L1 expression in macrophages

  Kevin Christian M. Gulay, et al., bioRxiv - Cancer Biology 2021

  Quote: ... anti-ERK1/2 antibody (1:1000; Cell Signaling Technology, 4695S), anti-H2AK119Ub1 antibody (1:2000 ...
• A phosphorylation of RIPK3 kinase initiates an intracellular apoptotic pathway that promotes corpus luteum regression

  Dianrong Li, et al., bioRxiv - Cell Biology 2021

  Quote: ... anti-Phospho-MEK1/2 (9154S, Cell Signaling; WB, 1:1000), anti-MEK1/2 (ab178876 ...
• Spatial modeling reveals nuclear phosphorylation and subcellular shuttling of YAP upon drug-induced liver injury

  Lilija Wehling, et al., bioRxiv - Molecular Biology 2022

  Quote: ... and pLATS1/2 (1:500, Cell Signaling Technology, #8654, RRID:AB_10971635) and Cytochrome P450 2E1 (1:500 ...
• Vitamin C functions as double-edge sword on cancer progression depending on ERK activation or inhibition mediated by its receptor SVCT2

  Yian Guan, et al., bioRxiv - Molecular Biology 2022

  Quote: ... anti-pERK1/2 (1:5000, Cat#9101, Cell Signaling Technology), anti-PTPN12 (1:500 ...
• Vitamin C functions as double-edge sword on cancer progression depending on ERK activation or inhibition mediated by its receptor SVCT2

  Yian Guan, et al., bioRxiv - Molecular Biology 2022

  Quote: ... anti-ERK1/2 (1:3000, Cat#4695, Cell Signaling Technology), anti-pERK1/2 (1:5000 ...