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1 - 9 of 9 citations for 6 HYDROXY 2 METHYL PYRIMIDINE 4 ACETIC ACID ETHYL ESTER since 2019

• Novel substrate prediction for the TAM family of RTKs using phosphoproteomics and structure-based modeling

  Naomi E. Widstrom, et al., bioRxiv - Biochemistry 2023

  Quote: ... 2 mM ATP) and 2 ug of recombinant kinase (SignalChem; Tyro3 (aa 455-end): T22-11G ...
• Calcium-dependent regulation of neuronal excitability is rescued in Fragile X Syndrome by a tat-conjugated N-terminal fragment of FMRP

  Xiaoqin Zhan, et al., bioRxiv - Neuroscience 2024

  Quote: ... 0.1 μg/ml MEK1 activated extracellular signal-regulated kinase 1 and 2 (pERK1/2) (SignalChem Biotech), 1 μM TTA-P2 (Alomone Labs) ...
• Identification and Mechanistic Characterization of a Peptide Inhibitor of Glycogen Synthase Kinase (GSK3β) Derived from the Disrupted in Schizophrenia 1 (DISC1) Protein

  Stephanie Saundh, et al., bioRxiv - Neuroscience 2020

  Quote: ... 4) 6X-HisGSK3β purchased from Signalchem (G09-10H-05) for BLI and MST experiments ...
• Diacylglycerol kinase-ε is S-palmitoylated on cysteine in the cytoplasmic end of its N-terminal transmembrane fragment

  Gabriela Traczyk, et al., bioRxiv - Cell Biology 2023

  Quote: ... 2 - 30 ng of GST-hDGKε (SignalChem, cat. No. D24–10G) was applied onto the gels ...
• Conservation of structure, function and inhibitor binding in UNC-51-like kinase 1 and 2 (ULK1/2)

  Apirat Chaikuad, et al., bioRxiv - Biochemistry 2019

  Quote: ... the 5 uL reaction was performed with 4 ug/mL recombinant human ULK2 protein (1-478, SignalChem #U02-11G) and 80 ug/mL MBP in the presence of 25 uM ATP ...
• Activation and inhibition of the C-terminal kinase domain of p90 ribosomal S6 kinases

  Marlene Uglebjerg Fruergaard, et al., bioRxiv - Biochemistry 2022

  Quote: ... RSK CTKD proteins (2 µM) were either untreated or pre-activated by ERK2 (0.1 µM) (Signalchem) in reaction buffer containing 200 µM ATP and 10 mM MgCl2 in kinase buffer (50 mM HEPES pH 7.0 ...
• The FDA-approved drug Alectinib compromises SARS-CoV-2 nucleocapsid phosphorylation and inhibits viral infection in vitro

  Tomer M. Yaron, et al., bioRxiv - Microbiology 2020

  Quote: ... All the recombinant kinases (SRPK1/2/3, GSK-3α/β and CK1A/E were obtained from SignalChem.
• Conservation of structure, function and inhibitor binding in UNC-51-like kinase 1 and 2 (ULK1/2)

  Apirat Chaikuad, et al., bioRxiv - Biochemistry 2019

  Quote: ... the 5 uL kinase reaction was performed with 2 ug/mL recombinant human ULK1 protein (1-649, SignalChem #U01-11G) and 80 ug/mL myelin basic protein (MBP ...
• TBK1 interacts with tau and enhances neurodegeneration in tauopathy

  Measho H. Abreha, et al., bioRxiv - Neuroscience 2020

  Quote: ... 2 mM EDTA and 0.25 mM DTT) plus 100 μM ATP for 30 min at 37°C (SignalChem, K01-09). TBK1 kinase activity was inhibited by adding 100 μM or 200 μM of BX795 (ENZ-CHM189-0005 ...