| Application |
- Solvent for many organic Compounds including fats, carbohydrates, dyes, resins, and polymers. In organic reactions. As antifreeze or hydraulic fluid when mixed with water. To cryopreserve and store cultured cells.Dimethyl sulfoxide is a highly polar substance that is aprotic, therefore lacking acidic and basic properties. It has exceptional solvent properties for both organic and inorganic components, which are derived from its capacity to associate with both ionic species and neutral molecules that are either polar or polarizable. Dimethyl sulfoxide enhances the topical penetration of drug sowing to its ability to displace bound water from the stratumcorneum;this is accompanied by the extraction of lipids and configurational changes of proteins.
- the solvent is diluted. Increases in drug penetration have been reported with dimethyl sulfoxide concentrations as low as 15%,but significant increases in permeability generally require concentrations higher than 60-80%. Furthermore, while low molecular weight substances can penetrate quickly into the deep layers of the skin, the appreciable transport of molecules with a molecular weight of more than 3000 is difficult.
- Dimethyl sulfoxide is now incorporated into a number of regulated products for healthcare and drug delivery applications, including stabilizing product formulations, sustained-release applications, and for the delivery of medical polymers.
- The use of dimethyl sulfoxide to improve transdermal delivery has been reported for diclofenac, ciclosporin, timolol, and a wide range of other drugs. Dimethyl sulfoxide has also been used in the formulation of an injection containing allopurinol. It has also been investigated for use in an experimental parenteral preparation for the treatment of liver tumors.
- In paint formulations of idoxuridine, dimethyl sulfoxide acts both as a solvent to increase drug solubility and a means of enabling penetration of the antiviral agent to the deeper levels of the epidermis.
- Dimethyl sulfoxide has also been investigated as a potential therapeutic agent in conditions such as scleroderma, interstitial cystitis,(12) rheumatoid arthritis, and acute musculoskeletal injuries, and as an analgesic.(13-17) It has also been recommended for the treatment of anthracycline extravasation(18-21) and has been investigated as a potential cryoprotectant.
|