Mutant Isocitrate Dehydrogenase 1 R132H from Human, Recombinant

Mutations of the cytosolic IDH 1 are a common feature in primary human brain cancers. Arginine 132 (R132) of IDH is highly conserved among different isoforms of IDH and is most commonly mutated to Histidine. Mutation of IDH1 R132H leads to accumulation of R(-)-2-hydroxyglutarate (2HG), which correlates with an increased risk for malignant brain tumors.

• Supplier: Creative Enzymes
• Product #: NATE-1649