CHMFL-ABL/KIT-155
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-101034 |
| CAS # | 2081093-21-0 |
| Pricing | inquire |
| Biological Activity | CHMFL-ABL/KIT-155 (CHMFL-ABL-KIT-155; compound 34) is a highly potent and orally active type II ABL/c-KIT dual kinase inhibitor (IC50s of 46 nM and 75 nM, respectively), and it also presents significant inhibitory activities to BLK (IC50=81 nM), CSF1R (IC50=227 nM), DDR1 (IC50=116 nM), DDR2 (IC50=325 nM), LCK (IC50=12 nM) and PDGFRβ (IC50=80 nM) kinases. CHMFL-ABL/KIT-155 (CHMFL-ABL-KIT-155) arrests cell cycle progression and induces apoptosis[1]. |
| Synonyms | CHMFL-ABL-KIT-155 |
| MWt | 609.68 |
| Formula | C₃₃H₃₈F₃N₅O₃ |