WDR5-IN-1
WDR5-IN-1 is a potent and selective inhibitor of WD repeat domain 5 (WDR5) (Kd of <0.02 nM), and also inhibits MLL1 histone methyltransferase (HMT) activity (IC50 of 2.2 nM). WDR5-IN-1 diminishes MYC recruitment at WDR5-displaced genes and exhibits potent anti-proliferative effects in CHP-134 (neuroblastoma) and Ramos (Burkitt's lymphoma) lines.
| Supplier | BOC Sciences |
|---|---|
| Product # | 2408842-51-1 |
| Pricing | Inquire |
| Cas | 2408842-51-1 |
| Molecular Weight | 514.59 |
| Molecular Formula | C30H31FN4O3 |
| Canonical SMILES | CC1=C(C=CC(=C1)F)C2=C3CCN(C(=O)C3=CC(=C2)CN4C=CN(C4=N)C)CC5=CC(=CC(=C5)OC)OC |