HLA class I histocompatibility antigen, B alpha chain (HLA-B) Antibody

HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described.
Supplier Abbexa Ltd.
Product # abx025843-80UL
Pricing 80 µl USD $326.25
Clonality Polyclonal
Conjugation Unconjugated
Host Rabbit
Tested Applications ELISA, WB
UniProt Primary AC P01889
Dry Ice No
Availability Shipped within 5-10 working days.
Note This product is for research use only.
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