RGB-286638 Free base
RGB-286638 is a novel CDK inhibitor. It inhibited several tyrosine and serine/threonine non-CDK enzymes, i.e. GSK-3β, TAK1, AMPK, Jak2, MEK1. It demonstrated equimolar (50nM) activity in freshly isolated tumor cells from MM patients, while manifesting less cytotoxicity in healthy donor PBMCs. It reduced the phosphorylation of Rb at S807/811 in MM.1S and MM.1R cells, but had no effects on p-Rb S780.
| Supplier | BOC Sciences |
|---|---|
| Product # | B0084-463330 |
| Pricing | Inquire |
| Cas | 784210-88-4 |
| Molecular Weight | 545.63 |
| Molecular Formula | C29H35N7O4 |
| Canonical SMILES | COCCN1CCN(CC1)CC2=CC=C(C=C2)C3=NNC4=C3C(=O)C5=C4C=CC=C5NC(=O)NN6CCOCC6 |