AP-18
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-W014421 |
| CAS # | 55224-94-7 |
| Pricing | inquire |
| Biological Activity | AP-18, a potent and selective TRPA1 inhibitor, blocks activation of TRPA1 by 50 μM Cinnamaldehyde with an IC50 of 3.1 μM and 4.5 μM for human and mouse TRPA1, respectively. AP-18 reverses complete Freund's adjuvant (CFA)-induced mechanical hyperalgesia in mice. AP-18 attenuated 30 μM AITC-induced Yo-Pro uptake in a concentration-dependent manner, with an IC50 of 10.3 μM[1][2][3]. |
| MWt | 209.67 |
| Formula | C₁₁H₁₂ClNO |