DNA-Binding Protein RFX5 (RFX5) Antibody
RFX5 Antibody is a Rabbit Polyclonal antibody against RFX5. A lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency, or the bare lymphocyte syndrome (BLS; MIM 209920). At least 4 complementation groups have been identified in B-cell lines established from patients with BLS. The molecular defects in complementation groups B, C, and D all lead to a deficiency in RFX, a nuclear protein complex that binds to the X box of MHC-II promoters. The lack of RFX binding activity in complementation group C results from mutations in the RFX5 gene encoding the 75-kD subunit of RFX (Steimle et al., 1995). RFX5 is the fifth member of the growing family of DNA-binding proteins sharing a novel and highly characteristic DNA-binding domain called the RFX motif. Multiple alternatively spliced transcript variants have been found but the full-length natures of only two have been determined.
Supplier | Abbexa Ltd. |
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Product # | abx005287-100UL |
Pricing | 100 µl USD $449.5 |
Clonality | Polyclonal |
Conjugation | Unconjugated |
Host | Rabbit |
Tested Applications | IF/ICC |
UniProt Primary AC | P48382 |
Dry Ice | No |
Availability | Shipped within 5-10 working days. |
Note | This product is for research use only. |