Recombinant Human Anti-DENV-1 Antibody (HMAb 1F4 )
Recombinant Human Antibody (HMAb 1F4 ) is capable of binding to DENV-1, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-DENV-1 mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-DENV-1 proteins mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. HMAb 1F4, a DENV1-specific Abs, can neutralize DENV at different stages of viral entry in a cell type and receptor dependent manner. HMAb 1F4 binds to the DI and DI-II hinge regions of the E protein monomer and that Ab binding is likely to be sensitive to the hinge angle between DI-II.
| Supplier | Creative Biolabs |
|---|---|
| Product # | PABL-443 |
| Pricing | Inquiry |
| Host | Human |
| Target | DENV-1 |
| Species Reactivity | DENV |
| Type | IgG |
| Applications |
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| Storage | Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples. |