Recombinant Human Anti-DENV-1 Antibody (HMAb 1F4 )

Recombinant Human Antibody (HMAb 1F4 ) is capable of binding to DENV-1, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-DENV-1 mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-DENV-1 proteins mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. HMAb 1F4, a DENV1-specific Abs, can neutralize DENV at different stages of viral entry in a cell type and receptor dependent manner. HMAb 1F4 binds to the DI and DI-II hinge regions of the E protein monomer and that Ab binding is likely to be sensitive to the hinge angle between DI-II.
Supplier Creative Biolabs
Product # PABL-443
Pricing Inquiry
Host Human
Target DENV-1
Species Reactivity DENV
Type IgG
Applications
  • ELISA 1:1000-1:20000
  • FC Assay-depended
  • Neut Assay-depended
Storage Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
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