Tanespimycin
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-10211-10 mg |
| CAS # | 75747-14-7 |
| Pricing | 10 mg, USD $72.0 |
| Synonyms | 17-AAG; NSC 330507; CP 127374 |
| MWt | 585.69 |
| Formula | C₃₁H₄₃N₃O₈ |
| Biological Activity | Tanespimycin (17-AAG) is a potent HSP90 inhibitor with an IC50 of 5 nM, having a 100-fold higher binding affinity for tumour cell derived HSP90 than normal cell derived HSP90[1][5]. Tanespimycin depletes cellular STK38/NDR1 and reduces STK38 kinase activity. Tanespimycin also downregulates the stk38 gene expression[3]. |
| Purity | ≥98.0% |