Pifithrin-α, p-Nitro, Cyclic

Supplier MedChemExpress
Product # HY-123076-100 mg
CAS # 60477-38-5
Pricing 100 mg, USD $860.0
Synonyms PFN-α
MWt 299.35
Formula C₁₅H₁₃N₃O₂S
Biological Activity Pifithrin-α, p-Nitro, Cyclic (PFN-α) is cell-permeable and active-form p53 inhibitor. Pifithrin-α, p-Nitro, Cyclic is one order magnitude more active than Pifithrin-α in protecting cortical neurons exposed to Etoposide (ED50=30 nM). Pifithrin-α, p-Nitro, Cyclic behaves as a p53 posttranscriptional activity inhibitor. Pifithrin-α, p-Nitro, Cyclic do not prevent p53 phosphorylation on the S15 residue[1][2].
Purity ≥99.0%
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