Vemurafenib (PLX4032)
Vemurafenib (PLX4032, RG7204, RO5185426) is a novel and potent inhibitor of B-RafV600E with IC50 of 31 nM in cell-free assay. 10-fold selective for B-RafV600E over wild-type B-Raf in enzymatic assays and the cellular selectivity can exceed 100-fold. Vemurafenib (PLX4032, RG7204) induces autophagy.
| Supplier | Selleck Chemicals |
|---|---|
| Product # | S1267 |
| Sku # | S1267-1g |
| Pricing | 1g, $1270.00 |
Citations for this product:
-
bioRxiv - Cancer Biology 2020Quote: ... and Vemurafenib (RAF-inh.; Cat.#S1267) were purchased from Selleck Chemicals (Houston, US). Additionally ...
-
bioRxiv - Systems Biology 2021Quote: We prepared stock solutions in DMSO of 4 mM vemurafenib (PLX4032, Selleck Chemicals, S1267), 10 mM pinometostat (Selleck Chemicals ...
-
bioRxiv - Cancer Biology 2020Quote: PLX4032 (vemurafenib, #S1267) and MS275 (entinostat, #1053) were purchased from Selleck Chemicals. Corin and Cpd7 were provided by Dr ...