AS2863619 free base
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-126675-10 mM * 1 mL |
| CAS # | 2241300-50-3 |
| Pricing | 10 mM * 1 mL, USD $256.0 |
| Biological Activity | AS2863619 free base enables conversion of antigen-specific effector/memory T cells into Foxp3+ regulatory T (Treg) cells for the treatment of various immunological diseases. AS2863619 free base is a potent, orally active cyclin-dependent kinase 8 (CDK8) and CDK19 inhibitor with IC50s of 0.61 nM and 4.28 nM, respectively. STAT5 activation enhanced by AS2863619 free base inhibition of CDK8/19, which consequently activates the Foxp3 gene[1]. |
| Purity | ≥98.0% |
| MWt | 332.32 |
| Formula | C₁₆H₁₂N₈O |