| Supplier |
CD BioSciences |
| Product # |
AMA-0706 |
| Pricing |
100 µg, Inquire
|
| Product Category |
Antibodies
|
| Application |
WB, F
|
| Reactivity |
Human, Mouse, Rat, Monkey
|
| Host |
Rabbit
|
| Gene ID |
1017
|
| UniProt ID |
|
| Source/Isotype |
Rabbit IgG
|
| MW (Target) |
33 kDa
|
| Storage |
Store at -20°C. Do not aliquot the antibody.
|
| Purification |
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues of human CDK2 .
|
| Background |
Cyclin-dependent kinase 2 (p33CDK2) is an important component of the cell cycle machinery. Like p34cdc2, kinase activity is regulated by phosphorylation state as well as association with a cyclin subunit and a CDK inhibitor. Inhibitory phosphorylation occurs on Thr14 and Tyr15 Inhibition of CDK2-cyclin complexes can also be attributed to association with p27 Kip1 and p21 Waf1/Cip1 Activation of CDK2 complexes requires dephosphorylation of Thr14 and Tyr15 by cdc25 phosphatase and phosphorylation of Thr160 which is mediated by CAK, a complex of CDK7 and cyclin H CDK2/cyclin E kinase activity is important for the G1 to S transition and phosphorylation of the Rb protein. During S-phase, active CDK2/cyclin A complexes predominate and phosphorylate E2F and the active CDK2 complex persists in the nucleus throughout G2.
|