Recombinant Human PI3K (p110 alpha/p85 alpha) (N-His tag)

The PI3K comprises of a 110 kDa catalytic subunit and a 85 kDa regulatory subunit. A number of isoforms of the 110 kDa catalytic subunit and the 85 kDa regulatory subunit exist in cells. The p110a catalytic subunit (PIK3CA) is frequently mutated or amplified in a variety of cancers including ovarian and colon and this protein is one of the PI3K mutants. PIK3CA gene copy number is increased in over 30% of ovarian cancers and this leads to increased PI3-kinase activity. Furthermore, the activity of p110a is essential for vascular development and inactivation of p110a leads to severe defects in angiogenic sprouting and vascular remodeling.

• Supplier: Amerigo Scientific
• Product #: Z500289