Native Rhodococcus rhodochrous Epoxide Hydrolase
Epoxide hydrolase (also known as epoxide hydratase) functions in detoxification during drug metabolism. It converts epoxides to trans-dihydrodiols, which can be conjugated and excreted from the body. Epoxides result from the degradation of aromatic compounds. Deficiency in this enzyme in patients receiving aromatic-type anti-epileptic drugs such as phenytoin is reported to lead to DRESS syndrome. Epoxides are significant as cytochrome P450 oxidase metabolites of unsaturated carbon-carbon bonds, but are also mutagenic. Epoxide hydrolase is present in large quantity on endoplasmic reticulum.
| Supplier | Creative Enzymes |
|---|---|
| Product # | NATE-0449 |
| Pricing | 100 ug, contact supplier for pricing |
| CAS | 9048-63-9 |