Recombinant Human PI3K (p110 beta/p85 alpha) (N-His tag)

The PI3K comprises of a 110 kDa catalytic subunit and a 85 kDa regulatory subunit. A number of isoforms of the 110 kDa catalytic subunit and the 85 kDa regulatory subunit exist in cells. The p110汕 catalytic subunit (PIK3CB) plays a role in regulating the formation and stability of alpha-2B-beta-3 integrin adhesion bonds, which are necessary for shear force-induced platelet activation. In animal model of prostate tumor formation induced by the tumor suppressor PTEN loss, ablation of p110汕 impedes tumorigenesis with a concomitant diminution of AKT phosphorylation.

• Supplier: Amerigo Scientific
• Product #: Z500290