Anti-TNFRSF12A immunotoxin ITEM-4 (scFv)-Gel
This immunotoxin was achieved by conjugating/fusing the Anti-TNFRSF12A scFv to gelonin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to TNFRSF12A overexpressed tumor cells. Once bind, the toxin enters cells by receptor-mediated endocytosis. Then, gelonin, like abrin and ricin, inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes. It was designed for treating malignant melanoma.
| Supplier | Creative Biolabs |
|---|---|
| Product # | AGTO-G061G |
| Pricing | Inquiry |
| Applications | This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy. |
| Host | Mouse |
| Target | TNFRSF12A |
| Species Reactivity | Human |