Recombinant E. coli LT-IIa, His-tagged

LT-IIa is a type II heat-labile enterotoxin produced by certain strains of Escherichia coli. The enterotoxin binds to GD1b, GD1a, GM1, and to several other gangliosides on the cell surface. The molecule induces high levels of cAMP in the cell upon intoxication. The molecule is also a very strong mucosal and systemic adjuvant when administered by peritoneal, intranasal, or intradermal routes. Single point substitution mutants of LT-IIa are available from Dr. T.D. Connell, upon request, that have altered ganglioside-binding and toxic activities.

• Supplier: Creative Biomart
• Product #: LT-910E