PF-543 Citrate
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-15425A-100 mg |
| CAS # | 1415562-83-2 |
| Pricing | 100 mg, USD $675.0 |
| Synonyms | Sphingosine Kinase 1 Inhibitor II Citrate |
| MWt | 657.73 |
| Formula | C₃₃H₃₉NO₁₁S |
| Biological Activity | PF-543 Citrate (Sphingosine Kinase 1 Inhibitor II Citrate) is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC50 of 2 nM and a Ki of 3.6 nM. PF-543 Citrate is >100-fold selectivity for SPHK1 over SPHK2. PF-543 Citrate is an effective potent inhibitor of sphingosine 1-phosphate (S1P) formation in whole blood with an IC50 of 26.7 nM. PF-543 Citrate induces apoptosis, necrosis, and autophagy[1][2][3]. |
| Purity | 98.35% |