IN-1130
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-18758-5 mg |
| CAS # | 868612-83-3 |
| Pricing | 5 mg, USD $100.0 |
| Biological Activity | IN-1130 is a highly selective transforming growth factor-β type I receptor kinase (ALK5) inhibitor with an IC50 of 5.3 nM for ALK5-mediated Smad3 phosphorylation. IN-1130 inhibits ALK5 phosphorylation of casein (IC50=36 nM) and p38α mitogen-activated protein kinase (IC50=4.3 μM). IN-1130 suppresses renal fibrosis in obstructive nephropathy and blocks breast cancer lung metastasis[1][2]. |
| MWt | 420.47 |
| Formula | C₂₅H₂₀N₆O |