APP Antibody
| Supplier | CD BioSciences |
|---|---|
| Product # | AMA-0194 |
| Pricing | 100 µg, Inquire |
| Product Category | Antibodies |
| Application | WB, IHC |
| Product Usage Information Dilution | Western Blotting (1-4 µg/mL); Immunohistochemistry (2-10 μg/mL) |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Gene ID | 351 |
| Source/Isotype | Rabbit IgG |
| Storage | Store at -20°C. |
| Purification | Affinity purified |
| Background | Accumulation of the amyloid-β peptide (Aβ) in the cerebral cortex is a critical event in the pathogenesis of Alzheimer’s disease. The β-amyloid protein precursor (APP) is cleaved by β-secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for g-secretase to generate the 4 kDa amyloid-β peptide, which is deposited in the brains of all suffers of Alzheimer’s disease. |