Vercirnon
Supplier | MedChemExpress |
---|---|
Product # | HY-15724-100 mg |
CAS # | 698394-73-9 |
Pricing | 100 mg, USD $2520.0 |
Synonyms | GSK-1605786; CCX282-B; Traficet-EN |
MWt | 444.93 |
Formula | C₂₂H₂₁ClN₂O₄S |
Biological Activity | Vercirnon (GSK1605786A) is an orally bioavailable, selective, and potent antagonist of CCR9. Vercirnon inhibits CCR9-mediated Ca2+ mobilization and chemotaxis on Molt-4 cells with IC50 values of 5.4 and 3.4 nM, respectively. Vercirnon is selective for CCR9 over CCR1-12 and CX3CR1-7 (IC50s>10 µM for all). Vercirnon is an equipotent inhibitor of CCL25-directed chemotaxis of both splice forms of CCR9 (CCR9A and CCR9B) with IC50 values of 2.8 and 2.6 nM, respectively[1]. |
Purity | 98.19% |