Kaolin
Kaolin occurs as a white to grayish-white colored, unctuous powder free from gritty particles. It has a characteristic earthy or claylike taste, and when moistened with water it becomes darker in color and develops a claylike odor.
| Supplier | CD Formulation |
|---|---|
| Product # | PE0382 |
| Pricing | , Inquire for price |
| product1 | Suspending Agents |
| Molecular Formula | Al2H4O9Si2 |
| Molecular Weight | 258.16 |
| Applications | Kaolin is a naturally occurring mineral used in oral and topical pharmaceutical formulations.In oral medicines, kaolin has been used as a diluent in tablet and capsule formulations; it has also been used as a suspending vehicle.In topical preparations, sterilized kaolin has been used in poultices and as a dusting powder. Therapeutically, kaolin has been used in oral antidiarrheal preparations. |
| Safety | Kaolin is used in oral and topical pharmaceutical formulations and is generally regarded as an essentially nontoxic and nonirritant material. Oral doses of about 2-6 g of kaolin every 4 hours have been administered in the treatment of diarrhea. |
| Incompatibilities | The adsorbent properties of kaolin may influence the absorption of other orally administered drugs. Drugs reportedly affected by kaolin include amoxicillin; ampicillin; cimetidine; digoxin; lincomycin; phenytoin; and tetracycline. Warfarin absorption byrat intestine in vitro was reported not to be affected by kaolin. With clindamycin, the rate (but not the amount) of absorption was affected by kaolin. |
| Synonyms | Argilla; bolus alba; China clay; E559; kaolinite; kaolinum ponderosum; Lion; porcelain clay; Sim 90; weisserton; white bole |
| CAS Number | 1332-58-7 |
| Category | Adsorbent; Suspending Agents; Tablet and Capsule Diluent |
| UNII | 24H4NWX5CO |
| Chemical Name | Hydrated aluminum silicate |
| Grade | Pharmceutical Excipients |
| Administration route | Oral; Topical |
| Dosage Form | Capsule, Powder for suspension, Syrup, Tablet |
| Stability and Storage Conditions | Kaolin is a stable material. Since it is a naturally occurring material, kaolin is commonly contaminated with microorganisms such as Bacillus anthracis, Clostridium tetani, and Clostridium welchii.However, kaolin may be sterilized by heating at a temperature greater than 160℃ for not less than 1 hour. When moistened with water, kaolin darkens and becomes plastic. Kaolin should be stored in a well-closed container in a cool, dry place. |