| Supplier |
Creative Peptides |
| Product # |
R1028 |
| CAS # |
65391-42-6 |
| Pricing |
Inquire
|
| LabelingTarget |
Aminopeptidase
|
| BoilingPoint |
604.7ºC at 760 mmHg
|
| MeltingPoint |
216-218 °C
|
| Synonyms |
Aminopeptidase inhibitor; leucine aminopeptidase; aminopeptidase B; NK-421
|
| MolecularFormula |
C16H24N2O4 · HCl
|
| MolecularWeight |
344.83
|
| Storage |
-20°C
|
| ShippingCondition |
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
|
| Explanation |
Bestatin hydrochloride is a reversible inhibitor of aminopeptidase enzymes, namely Aminopeptidase B, Aminopeptidase M (CD13), and leucine aminopeptidase (LAP3). Inhibition of these proteins by bestatin correlates to apoptosis induction in oncogenic cells. Bestatin is also a potent inhibitor of leukotriene A4 hydrolase (LTA4). It is potentially used for cancer treatment.
|
| Activity |
Inhibitor
|
| InChI |
InChI=1S/C16H24N2O4.ClH/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11;/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22);1H/t12-,13+,14+;/m1./s1
|
| InChIKey |
XGDFITZJGKUSDK-UDYGKFQRSA-N
|
| Solubility |
Soluble in DMSO
|
| IsomericSMILES |
CC(C)C[C@@H](C(=O)O)NC(=O)[C@H]([C@@H](CC1=CC=CC=C1)N)O.Cl
|
| Appearance |
White solid powder
|
| Purity |
>98% (or refer to the Certificate of Analysis)
|
| ShortTermStorageConditions |
Dry, dark and at 0 - 4 °C
|
| LongTermStorageConditions |
-20 °C
|