anti-IL2RA immunotoxin RFT5 (IgG)-RTA
This immunotoxin was achieved by conjugating/fusing the Anti-IL2RA monoclonal antibody to ricin A chain. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to Hodgkin's lymphoma cells. Then the ricin A chain is incorporated into the cell by receptor-mediated endocytosis, blocking ribosomal protein synthesis and ultimately leading to cell death. It was designed for treatment of Hodgkin's lymphoma.
Supplier | Creative Biolabs |
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Product # | AGTO-L028R |
Pricing | Inquiry |
Applications | This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy. |
Host | Mouse |
Target | IL2RA |
Species Reactivity | Human |