L-685458
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-19369-1 mg |
| CAS # | 292632-98-5 |
| Pricing | 1 mg, USD $168.0 |
| Synonyms | L-685,458 |
| MWt | 672.85 |
| Formula | C₃₉H₅₂N₄O₆ |
| Biological Activity | L-685458 is a potent transition state analog (TSA) γ-secretase inhibitor (GSI). L-685458 inhibits amyloid β-protein precursor γ-secretase activity with IC50 of 17 nM, shows greater than 50-100-fold selectivity over other aspartyl proteases tested. L685458 inhibits γ-secretase-mediated cleavage of APP-C99 and Notch-100 with IC50s of 301.3 nM and 351.3 nM, respectively. L-685458 can be used for the research of alzheimer’s disease (AD) and cancers[1][2]. |
| Purity | 99.78% |