Hck-IN-1
Hck-IN-1 is a selective inhibitor of Nef-dependent Hck with IC50s of 2.8 and >20 μM for Nef:Hck complex and Hck, respectively. Hck-IN-1 is a direct and wide antagonist of HIV-1 Nef with an IC50 of 100-300 nM for wild-type HIV-1 replication. It binds pocket residue Asn126 and has anti-retroviral activity.
| Supplier | BOC Sciences |
|---|---|
| Product # | 1473404-51-1 |
| Pricing | Inquire |
| Cas | 1473404-51-1 |
| Molecular Weight | 402.81 |
| Molecular Formula | C16H11ClN6O3S |
| Canonical SMILES | C1=CC(=CC(=C1)Cl)N=NC2=C(NN(C2=O)C(=S)N)C3=CC=C(C=C3)[N+](=O)[O-] |