| Supplier |
CD Formulation |
| Product # |
PE-0482 |
| Pricing |
, Inquire for price
|
| product1 |
Pharmaceutical Excipients
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| Molecular Formula |
C12H19Cl3O8
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| Molecular Weight |
397.64
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| Applications |
Sucralose is used as a sweetening agent in beverages, foods, and pharmaceutical applications. It has a sweetening power approximately 300-1000 times that of sucrose and has no aftertaste. It has no nutritional value, is noncariogenic, does not promote dental caries, and produces no glycemic response.
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| Safety |
- Sucralose is generally regarded as a nontoxic and nonirritant material and is approved, in a number of countries, for use in food products. Following oral consumption, sucralose is mainly unabsorbed and is excreted in the feces. The WHO has set an acceptable daily intake for sucralose of up to 15 mg/kg body-weight.
- LD50 (mouse, oral): > 16 g/kg
- LD50 (rat, oral): > 10 g/kg
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| Incompatibilities |
/
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| Synonyms |
Splenda; sucralosa; sucralosum; SucraPlus; TGS; 1′, 4′, 6′-trichlorogalactosucrose; 4, 1′, 6′-trichloro-4, 1′, 6′-trideoxy-galacto-sucrose.
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| CAS Number |
56038-13-2
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| Category |
Sweetening agent
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| UNII |
96K6UQ3ZD4
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| Chemical Name |
1, 6-Dichloro-1, 6-dideoxy-β-D-fructofuranosyl-4-chloro-4-deoxya-α-D-galactopyranoside
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| Grade |
Pharmceutical Excipients
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| Stability and Storage Conditions |
Sucralose is a relatively stable material. In aqueous solution, at highly acidic conditions (pH < 3), and at high temperatures (≤35℃), it is hydrolyzed to a limited extent, producing 4-chloro-4-deoxygalactose and 1, 6-dichloro-1, 6-dideoxyfructose. In food products, sucralose remains stable throughout extended storage periods, even at low pH. However, it is most stable at pH 5-6. Sucralose should be stored in a well-closed container in a cool, dry place, at a temperature not exceeding 21℃. Sucralose, when heated at elevated temperatures, may break down with the release of carbon dioxide, carbon monoxide, and minor amounts of hydrogen chloride.
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| Source and Preparation |
Sucralose may be prepared by a variety of methods that involve the selective substitution of three sucrose hydroxyl groups by chlorine.Sucralose can also be synthesized by the reaction of sucrose (or an acetate) with thionyl chloride.
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