| Supplier |
CD Formulation |
| Product # |
PE-0636 |
| Pricing |
, Inquire for price
|
| product1 |
Excipients for Liquid Dosage Form
|
| Molecular Formula |
C3H8O3
|
| Molecular Weight |
92.09
|
| Applications |
Glycerol is mainly used as solvent and suspending agent in injectable preparations.
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| Safety |
Glycerol is found naturally in animal and vegetable fats and oils and can be digested as part of regular food. Glycerol is easily absorbed by the small intestine and metabolized as carbon dioxide, liver sugar, or synthetic body fat. Glycerin is widely used in oral, ophthalmic, topical and injectable preparations, and the adverse reactions mainly come from the dewatering of glycerin. No toxicity was observed after delayed administration. LD50 (mouse, IP): 8.98 g/kg LD50 (mouse, IV): 4.25 g/kg LD50 (mouse, SC): 0.09 g/kg LD50 (rabbit, IV): 0.05 g/kg LD50 (rat, IP): 4.42 g/kg LD50 (rat, SC): 0.1 g/kg Maximum dosage of intravenous injection 22.50%; The maximum dosage of intramuscular injection is 15.36%; The maximum dosage of subcutaneous injection was 32.50%.
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| Incompatibilities |
Glycerin may explode if mixed with strong oxidants (e.g., chromium trioxide, potassium chlorate, potassium permanganate, etc.). The reaction rate is low in dilute solution, and several oxidation products are generated. Glycerol turns black when exposed to light or contact with basic bismuth nitrate and zinc oxide. Mixtures containing phenol, salicylic acid, and danic acid can be blackened if iron contaminants are involved. Glycerol forms a boric acid complex (glyceroborate), which is more acidic than boric acid.
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| Synonyms |
Glycerin(USP); Concentrated Glycerin(JP); glycerolum(PhEur)
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| CAS Number |
56-81-5
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| Category |
Solvent; Suspending Agents
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| UNII |
PDC6A3C0OX
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| Chemical Name |
1, 2, 3-Propanetriol; Propane-1, 2, 3-triol
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| Grade |
Pharmceutical Excipients
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| Administration route |
Absorbent; Injection; Nasal and ocular; Oral; Ear, rectum, local, transdermal, vaginal
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| Dosage Form |
Absorbent; Injection; Nasal and ocular preparations; Oral capsules; A solution; Suspension agent; Tablets; Ear, rectum, local, transdermal, vaginal administration preparations
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| Stability and Storage Conditions |
Glycerin is hygroscopic. Under normal storage conditions, pure glycerol is not easily oxidized by air, but when heated, it degrades and generates toxic acrolein. Glycerol is chemically stable with the mixture of water, ethanol and propylene glycol. Glycerol may crystallize if stored at low temperature, and the crystals will not melt until above 20℃. Glycerin should be stored in a cool, dry place in an airtight container.
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| Source and Preparation |
Glycerol is mainly produced from oils and fats as a by-product in the production of soap and fatty acids, or from natural products such as beetroot molasses fermented in the presence of large quantities of sodium sulfite. In terms of chemical synthesis, propylene can be prepared by chlorination and saponification.
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