3-Hydroxy Midostaurin
Supplier | MedChemExpress |
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Product # | HY-108263-50 mg |
CAS # | 179237-49-1 |
Pricing | 50 mg, USD $5500.0 |
Biological Activity | 3-Hydroxy Midostaurin (CGP 52421), a metabolite of PKC412, effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50s of approximately 132 nM and 9.8 μM in culture medium and plasma, respectively. 3-Hydroxy Midostaurin is less selective but more cytotoxic than PKC412[1]. |
Synonyms | CGP52421 |
MWt | 586.64 |
Formula | C₃₅H₃₀N₄O₅ |