Nebentan
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-106994-10 mM * 1 mL |
| CAS # | 403604-85-3 |
| Pricing | 10 mM * 1 mL, USD $270.0 |
| Synonyms | YM598 free base |
| MWt | 491.52 |
| Formula | C₂₄H₂₁N₅O₅S |
| Biological Activity | Nebentan (YM598 free base) is a potent, selective and orally active non-peptide endothelin ETA receptor antagonist through the modification of Bosentan (HY-A0013). Nebentan inhibits [125I] endothelin-1 binding to cloned human endothelin ETA and ETB receptor, with Ki of 0.697 nM and 569 nM, respectively[1]. YM598 can ameliorate the progression of cor pulmonale and myocardial infarction in vivo[2]. |
| Purity | 99.67% |